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United States Cruise Departures

Cruises that depart from North America: United States

Cruises that visit United States

See all River Cruises that depart from United States

Click on a cruise ship itinerary sailing from United States (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just United States), please visit: Cruise Search or try our Virtual Cruise Advisor™.

Related areas: Alabama : Alaska : California : Florida : Hawaii : Illinois : Kentucky : Louisiana : Maine : Maryland : Massachusetts : Minnesota : Missouri : New Jersey : New York : Oklahoma : Oregon : Pennsylvania : Rhode Island : South Carolina : Tennessee : Texas : Virginia : Washington : Washington DC : Wisconsin : Wyoming

Departing from
United States
Cruise Specials

Princess Tours, Coral Princess Tours
Coral Princess Tours12 Night - Connoisseur Escorted - Tour Rb5
Starting in Anchorage, Mount Mckinley Princess Wilderness Lodge, Denali Princess Wilderness Lodge, Anchorage (Whittier), Alaska, Hubbard Glacier (Scenic Cruising), Alaska, Glacier Bay National Park (Scenic Cruising), Alaska, Skagway, Alaska, Juneau, Alaska, Ketchikan, Alaska, Vancouver, Canada
2026 Sails: Aug 14, More...
Princess Tours, Coral Princess Tours
Coral Princess Tours12 Night - Denali Explorer - Tour Ib5
Starting in Fairbanks, Denali Princess Wilderness Lodge, Mount Mckinley Princess Wilderness Lodge, Anchorage (Whittier), Alaska, Hubbard Glacier (Scenic Cruising), Alaska, Glacier Bay National Park (Scenic Cruising), Alaska, Skagway, Alaska, Juneau, Alaska, Ketchikan, Alaska, Vancouver, Canada
2026 Sails: Aug 14, Aug 28, More...
Princess Tours, Coral Princess Tours
Coral Princess Tours12 Night - Denali Explorer - Tour Hb5
Starting in Anchorage, Mount Mckinley Princess Wilderness Lodge, Denali Princess Wilderness Lodge, Anchorage (Whittier), Alaska, Hubbard Glacier (Scenic Cruising), Alaska, Glacier Bay National Park (Scenic Cruising), Alaska, Skagway, Alaska, Juneau, Alaska, Ketchikan, Alaska, Vancouver, Canada
2026 Sails: Aug 14, Aug 28, More...
Princess Tours, Coral Princess Tours
Coral Princess Tours12 Night - Denali Explorer - Tour Jb5
Starting in Fairbanks, Denali Princess Wilderness Lodge, Anchorage, Anchorage (Whittier), Alaska, Hubbard Glacier (Scenic Cruising), Alaska, Glacier Bay National Park (Scenic Cruising), Alaska, Skagway, Alaska, Juneau, Alaska, Ketchikan, Alaska, Vancouver, Canada
2026 Sails: Aug 14, Aug 28, More...
Princess Tours, Discovery Princess Tours
Discovery Princess Tours15 Night - Connoisseur Escorted - Tour Ub8
Starting in Fairbanks, Denali Princess Wilderness Lodge, Mount Mckinley Princess Wilderness Lodge, Kenai Princess Wilderness Lodge, Anchorage (Whittier), Alaska, Hubbard Glacier (Scenic Cruising), Alaska, Glacier Bay National Park (Scenic Cruising), Alaska, Icy Strait Point, Alaska, Juneau, Alaska, Ketchikan, Alaska, Vancouver, Canada
2026 Sails: Aug 14, More...
Princess Tours, Discovery Princess Tours
Discovery Princess Tours15 Night - Off the Beaten Path - Tour Qb8
Starting in Fairbanks, Denali Princess Wilderness Lodge, Mount Mckinley Princess Wilderness Lodge, Copper River Princess Wilderness Lodge, Kenai Princess Wilderness Lodge, Anchorage (Whittier), Alaska, Hubbard Glacier (Scenic Cruising), Alaska, Glacier Bay National Park (Scenic Cruising), Alaska, Icy Strait Point, Alaska, Juneau, Alaska, Ketchikan, Alaska, Vancouver, Canada
2026 Sails: Aug 14, More...
Royal Caribbean, Jewel of the Seas
Jewel of the Seas3 Night - Bahamas Getaway Cruise
Starting in Fort Lauderdale, Florida, Grand Bahama Island, Bahamas, Nassau, Bahamas, Fort Lauderdale, Florida
2026 Sails: Aug 14, More...
Royal Caribbean, Ovation Of The Seas
Ovation Of The Seas7 Night - Southbound Alaska & Hubbard Glacier
Starting in Seward, Alaska, Hubbard Glacier (Cruising), Juneau, Alaska, Skagway, Alaska, Icy Strait Point, Alaska, Vancouver, British Columbia
2026 Sails: Aug 14, More...
American Cruise Lines, American Patriot
American Patriot13 Night - American Great Lakes Cruise
Starting in Milwaukee, WI, Day of Cruising, Holland, MI, Muskegon, MI, Day of Cruising, Mackinac Island, MI, Sault Ste Marie, MI, Day of Cruising, Alpena, MI, Day of Cruising, Detroit, MI, Toledo, OH, Buffalo, NY
2026 Sails: Aug 15, Sep 22, 2027: Jun 4, Aug 2, Sep 16, 2028: Jun 3, Aug 1, Sep 16, More...
American Lines Tours, American Splendor Tours
American Splendor Tours11 Night - Smoky Mountains National Park
Starting in Knoxville, TN, Pigeon Forge, TN, Great Smoky Mountain National Park, Chattanooga, TN, Decatur, AL, Florence, AL, Savannah, TN, Paducah, KY, Cruising Lake Barkley and the Cumberland River, Nashville, TN
2026 Sails: Aug 15, Aug 29, Sep 12, Sep 26, Oct 10, More...

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United States Cruise Departures