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St Louis River Cruise Departures

River Cruises that depart from North America: United States: Missouri: St Louis

River Cruises that visit St Louis

See all Cruises that depart from St Louis

Mississippi River Cruises

Click on a cruise ship itinerary sailing from St Louis (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just St Louis), please visit: Cruise Search or try our Virtual Cruise Advisor™.

River cruises by river name


American Duchess Cruises8 Night - Ohio River and Tennessee River Cruise from St. Louis to Cincinnati
Starting in St. Louis, MO; with stops in Cape Girardeau, MO; Paducah, KY; Henderson, KY; Louisville, KY; Madison, IN; Cincinnati, OH
2021 Sails: Apr 18, More...
American Duchess Cruises8 Night - Ohio River and Tennessee River Cruise from St. Louis to Memphis
Starting in St. Louis, MO; with stops in Alton, IL; Chester, IL; Cape Girardeau, MO; Paducah, KY; New Madrid, MO; Ashport Landing, TN; Memphis, TN
2021 Sails: May 9, Oct 3, More...
American Duchess Cruises8 Night - Upper Mississippi River Cruise from St. Louis (Alton) to Minneapolis (Red Wing)
Starting in St. Louis; with stops in Alton, IL; Hannibal, MO; Bettendorf, IA; Dubuque, IA; La Crosse, WI; Red Wing, MN;
2021 Sails: Jul 11, More...
American Queen Cruises8 Night - Upper Mississippi River Cruise from St. Louis (Alton) to Minneapolis (Red Wing)
Starting in St. Louis; with stops in Alton, IL; Hannibal, MO; Clinton, IA; Dubuque, IA; La Crosse, WI; Red Wing, MN;
2021 Sails: Jul 18, More...
America Cruises7 Night - Upper Mississippi River Cruise from St. Louis, MO to St. Paul, MN - America
Starting in St. Louis, MO/Alton, IL; with stops in Hannibal, MO; Fort Madison, IA; Davenport, IA; Dubuque, IA; La Crosse, WI; Red Wing, MN; St. Paul, MN
2021 Sails: Jul 21, Aug 4, Sep 4, Sep 18, Oct 2, Oct 16, 2022: Jul 20, Aug 3, Sep 3, Sep 17, Oct 1, Oct 15, More...
Queen of the Mississippi Cruises10 Night - Ohio River Cruise from St. Louis to Pittsburgh, PA
Starting in St. Louis, MO; with stops in Cape Girardeau, MO; Paducah, KY; Henderson, KY; Louisville, KY; Cincinnati, OH; Maysville, KY; Marietta, OH; Pittsburgh, PA
2021 Sails: Aug 10, Aug 30, Sep 19, More...
American Melody Cruises7 Night - Upper Mississippi River Cruise from St. Louis, MO to St. Paul, MN
Starting in St. Louis, MO/Alton, IL; with stops in Hannibal, MO; Fort Madison, IA; Davenport, IA; Dubuque, IA; La Crosse, WI; Red Wing, MN; St. Paul, MN
2021 Sails: Oct 1, Oct 15, Oct 29, 2022: Jun 22, Aug 5, Aug 19, Sep 2, Sep 16, Sep 30, Oct 14, Oct 28, 2023: Jul 7, Jul 21, Aug 4, Aug 18, Sep 1, More...
American Countess Cruises8 Night - Lower Mississippi River Cruise from St. Louis to New Orleans
Starting in St. Louis; with stops in Memphis, TN; Port of the Mississippi Delta/Greenville, TN; Vicksburg, MS; Natchez, MS; Nottoway Plantation; New Orleans, LA
2021 Sails: Oct 16, More...
Viking Mississippi Cruises7 Night - America's Heartland - St. Louis to St. Paul
Starting in St. Louis with stops in Hannibal, Burlington, Quad Cities, Dubuque, La Crosse, Red Wing, St. Paul
2022 Sails: Aug 27, Sep 10, More...
Viking Mississippi Cruises7 Night - America's Heartland - St. Louis to St. Paul
Starting in St. Louis with stops in Hannibal, Burlington, Quad Cities, Dubuque, La Crosse, Red Wing, St. Paul
2023 Sails: Aug 12, Aug 26, Sep 9, More...

St Louis River Cruise Departures

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