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St Louis River Cruise Departures

River Cruises that depart from North America: United States: Missouri: St Louis

River Cruises that visit St Louis

Mississippi River Cruises

Click on a river cruise ship itinerary sailing from St Louis (below) and select a sail date to receive competing cruise quotes. To search all river cruise itineraries (not just St Louis), please visit: Cruise Search or try our Virtual Cruise Advisor™.





American Duchess Cruises8 Night - Ohio River and Tennessee River Cruise from St. Louis to Cincinnati
Starting in St. Louis, MO; with stops in Cape Girardeau, MO; Paducah, KY; Henderson, KY; Louisville, KY; Madison, IN; Cincinnati, OH
2021 Sails: Apr 18, More...
American Duchess Cruises8 Night - Ohio River and Tennessee River Cruise from St. Louis to Memphis
Starting in St. Louis, MO; with stops in Alton, IL; Chester, IL; Cape Girardeau, MO; Paducah, KY; New Madrid, MO; Ashport Landing, TN; Memphis, TN
2021 Sails: May 9, Oct 3, More...
American Duchess Cruises8 Night - Upper Mississippi River Cruise from St. Louis (Alton) to Minneapolis (Red Wing)
Starting in St. Louis; with stops in Alton, IL; Hannibal, MO; Bettendorf, IA; Dubuque, IA; La Crosse, WI; Red Wing, MN;
2021 Sails: Jul 11, More...
American Queen Cruises8 Night - Upper Mississippi River Cruise from St. Louis (Alton) to Minneapolis (Red Wing)
Starting in St. Louis; with stops in Alton, IL; Hannibal, MO; Clinton, IA; Dubuque, IA; La Crosse, WI; Red Wing, MN;
2021 Sails: Jul 18, More...
America Cruises7 Night - Mississippi River from St. Louis, MO to St. Paul, MN
Starting in St. Louis, MO; with stops in Hannibal, MO; Davenport, IA; Dubuque, IA; La Crosse, WI; Red Wing, MN; St. Paul, MN
2021 Sails: Jul 21, Aug 4, Sep 4, Sep 18, Oct 2, Oct 16, More...
Queen of the Mississippi Cruises10 Night - Mississippi River Gateway Cruise from St Louis, Missouri to New Orleans, Louisiana
Starting in St Louis, with stops in Cruising the Ohio River, Paducah, New Madrid, Memphis, Cruising the Mississippi River, Vicksburg, Natchez, Baton Rouge, New Orleans
2021 Sails: Jul 31, More...
Queen of the Mississippi Cruises10 Night - Ohio River Cruise from St. Louis to Pittsburgh, PA
Starting in St. Louis, MO; with stops in Cape Girardeau, MO; Paducah, KY; Henderson, KY; Louisville, KY; Cincinnati, OH; Maysville, KY; Marietta, OH; Pittsburgh, PA
2021 Sails: Aug 10, Aug 30, Sep 19, More...
American Countess Cruises8 Night - Upper Mississippi River Cruise from St. Louis to Minneapolis (Red Wing)
Starting in St. Louis; with stops in Alton, IL; Hannibal, MO; Clinton, IA; La Crosse, WI; Red Wing, MN;
2021 Sails: Aug 21, Oct 2, More...
Queen of the Mississippi Cruises7 Night - Mississippi River from St. Louis, MO to St. Paul, MN
Starting in St. Louis, MO; with stops in Hannibal, MO; Davenport, IA; Dubuque, IA; La Crosse, WI; Red Wing, MN; St. Paul, MN
2021 Sails: Oct 9, Oct 23, More...
American Countess Cruises8 Night - Lower Mississippi River Cruise from St. Louis to New Orleans
Starting in St. Louis; with stops in Memphis, TN; Port of the Mississippi Delta/Greenville, TN; Vicksburg, MS; Natchez, MS; Nottoway Plantation; New Orleans, LA
2021 Sails: Oct 16, More...


St Louis River Cruise Departures
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