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St Louis River Cruise Departures

River Cruises that depart from North America: United States: Missouri: St Louis

River Cruises that visit St Louis

See all Cruises that depart from St Louis

Mississippi River Cruises

Click on a cruise ship itinerary sailing from St Louis (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just St Louis), please visit: Cruise Search or try our Virtual Cruise Advisor™.

River cruises by river name


American Duchess Cruises8 Night - Special Edition Voyages - Culinary & Cocktails - American Culinary Experience Cruise from St. Louis to Memphis
Starting in St. Louis, MO; with stops in Alton, IL; Chester, IL; Cape Girardeau, MO; Paducah, KY; New Madrid, MO; Ashport Landing, TN; Memphis, TN
2021 Sails: May 9, Oct 3, More...
American Duchess Cruises8 Night - Upper Mississippi River - Mark Twains Mississippi Cruise from St. Louis (Alton) to Minneapolis (Red Wing)
Starting in St. Louis, MO; with stops in Alton, IL; Hannibal, MO; Clinton, IA; Dubuque, IA; La Crosse, WI; Red Wing, MN
2021 Sails: Jul 11, 2022: Jul 23, Sep 3, Sep 17, 2023: Aug 12, Aug 26, Sep 9, More...
American Queen Cruises8 Night - Upper Mississippi River - Mark Twains Mississippi Cruise from St. Louis (Alton) to Minneapolis (Red Wing)
Starting in St. Louis, MO; with stops in Alton, IL; Hannibal, MO; Clinton, IA; Dubuque, IA; La Crosse, WI; Red Wing, MN
2021 Sails: Jul 18, 2022: Aug 21, Sep 4, Oct 9, 2023: Jul 16, Jul 30, Sep 24, More...
America Cruises7 Night - Upper Mississippi River Cruise from St. Louis, MO to St. Paul, MN
Starting in St. Louis, MO; with stops in Hannibal, MO; Fort Madison, IA; Davenport, IA; Dubuque, IA; Winona, MN; Red Wing, MN; St. Paul, MN
2021 Sails: Jul 21, Aug 4, Sep 4, Sep 18, Oct 2, Oct 16, 2022: Jul 20, Aug 3, Sep 3, Sep 17, Oct 1, Oct 15, 2023: Jul 19, Aug 2, More...
Queen of the Mississippi Cruises7 Night - Upper Mississippi River Cruise from St. Louis, MO to St. Paul, MN
Starting in St. Louis, MO; with stops in Hannibal, MO; Fort Madison, IA; Davenport, IA; Dubuque, IA; Winona, MN; Red Wing, MN; St. Paul, MN
2021 Sails: Jul 27, More...
Queen of the Mississippi Cruises10 Night - Ohio River Cruise from St. Louis to Pittsburgh, PA
Starting in St. Louis, MO; with stops in Cape Girardeau, MO; Paducah, KY; Henderson, KY; Louisville, KY; Cincinnati, OH; Maysville, KY; Marietta, OH; Pittsburgh, PA
2021 Sails: Aug 10, Aug 30, Sep 19, 2022: Aug 6, Aug 26, Sep 15, 2023: Aug 5, Aug 25, More...
American Countess Cruises8 Night - Upper Mississippi River - Mark Twains Mississippi Cruise from St. Louis (Alton) to Minneapolis (Red Wing)
Starting in St. Louis, MO; with stops in Alton, IL; Hannibal, MO; Clinton, IA; Dubuque, IA; La Crosse, WI; Red Wing, MN
2021 Sails: Aug 21, Oct 2, 2022: Jul 11, Jul 25, Sep 19, 2023: Jul 17, Aug 29, More...
American Melody Cruises7 Night - Upper Mississippi River Cruise from St. Louis, MO to St. Paul, MN
Starting in St. Louis, MO; with stops in Hannibal, MO; Fort Madison, IA; Davenport, IA; Dubuque, IA; Winona, MN; Red Wing, MN; St. Paul, MN
2021 Sails: Oct 1, Oct 15, Oct 29, 2022: Jul 8, Jul 22, Aug 5, Aug 19, Sep 2, Sep 16, Sep 30, Oct 14, Oct 28, 2023: Jul 7, Jul 21, Aug 4, Aug 18, Sep 1, More...
Queen of the Mississippi Cruises10 Night - Mississippi River Gateway Cruise from St. Louis, MO to New Orleans, LA
Starting in St. Louis, MO; with stops in Paducah, KY; New Madrid, MO; Memphis, TN; Vicksburg, MS; Natchez, MS; Baton Rouge, LA; New Orleans, LA
2021 Sails: Oct 9, 2022: Oct 5, More...
American Countess Cruises8 Night - Special Edition Voyages - Community Outreach - Breast Cancer Awareness Cruise from St. Louis to New Orleans
Starting in St. Louis, MO; with stops in Alton, IL; Memphis, TN; Port of the Mississippi Delta; Vicksburg, MS; Natchez, MS; Nottoway; New Orleans, LA
2021 Sails: Oct 16, More...


St Louis River Cruise Departures

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