San Diego Cruise Departures
Cruises that depart from North America: United States: California: San Diego
Cruises that visit San Diego
17 Night - Circle Hawaii
Starting in San Diego, California, Kahului, Maui, Hilo, Hawaii, Kona, Hawaii, Honolulu, Hawaii, Nawiliwili, Kauai, Hawaii, Ensenada, Mexico, San Diego, California
2026 Sails: Jan 10, More...
7 Night - Mexican Riviera - San Diego
Starting in San Diego, Ca, Puerto Vallarta, Mexico, Mazatlan, Mexico, Cabo San Lucas, Mexico, San Diego, Ca
2026 Sails: Jan 10, Jan 24, Jan 31, More...7 Night - Mexican Riviera - San Diego
Starting in San Diego, Ca, Cabo San Lucas, Mexico, Mazatlan, Mexico, Puerto Vallarta, Mexico, San Diego, Ca
2026 Sails: Jan 17, More...18 Night - Circle Hawaii
Starting in San Diego, California, Hilo, Hawaii, Kona, Hawaii, Kahului, Maui, Honolulu, Hawaii, Nawiliwili, Kauai, Hawaii, Ensenada, Mexico, San Diego, California
2026 Sails: Jan 27, More...5 Night - Mexican Riviera - San Diego
Starting in San Diego, Ca, Cabo San Lucas, Mexico, San Diego, Ca
2026 Sails: Feb 7, More...15 Night - Panama Canal-Panama City
Starting in San Diego, Ca, Cabo San Lucas, Mexico, Acapulco, Mexico, Puerto Quetzal, Guatemala, Puntarenas / Puerto Caldera, Costa Rica, Panama City, Panama, Transit Panama Canal / At Sea, Cartagena CO, Miami, Fl
2026 Sails: Feb 12, More...35 Night - Hawaii, Tahiti & Marquesas
Starting in San Diego, California, Kahului, Maui, Hilo, Hawaii, Honolulu, Hawaii, Nawiliwili, Kauai, Hawaii, Kona, Hawaii, Cross International Dateline, Tabuaeran (Fanning Island), Kiribati, Crossing the Equator, Cross International Dateline, Raiatea, Society Islands, French Polynesia, Papeete, French Polynesia, Bahia d Opunoha, Moorea, French Polynesia, Fakarava, Tuamotu, French Polynesia, Taiohae, Nuku Hiva, French Polynesia, Crossing the Equator, San Diego, California
2026 Sails: Feb 14, More...
27 Night - Historic Sea of Cortez & Panama Canal
Starting in San Diego, California, Cabo San Lucas, Mexico, Pichilingue (La Paz), Mexico, Loreto, Mexico, Guaymas, Mexico, Topolobampo, Mexico, Mazatlan, Mexico, Puerto Vallarta, Mexico, Ensenada, Mexico, San Diego, California, Puerto Vallarta, Mexico, Huatulco, Mexico, Puerto Chiapas, Mexico, Puerto Quetzal, Guatemala, Fuerte Amador, Panama, Enter Panama Canal Balboa, Cruising Panama Canal, Exit Panama Canal Cristobal, Cartagena CO, Half Moon Cay, Bahamas, Miami, Florida
2026 Sails: Feb 15, More...12 Night - Historical Baja Peninsula
Starting in San Diego, California, Cabo San Lucas, Mexico, Pichilingue (La Paz), Mexico, Loreto, Mexico, Guaymas, Mexico, Topolobampo, Mexico, Mazatlan, Mexico, Puerto Vallarta, Mexico, Ensenada, Mexico, San Diego, California
2026 Sails: Feb 15, More...26 Night - Panama Canal & Eastern Caribbean
Starting in San Diego, California, Puerto Vallarta, Mexico, Huatulco, Mexico, Puerto Chiapas, Mexico, Puerto Quetzal, Guatemala, Fuerte Amador, Panama, Enter Panama Canal Balboa, Cruising Panama Canal, Exit Panama Canal Cristobal, Cartagena CO, Half Moon Cay, Bahamas, Miami, Florida, Philipsburg, Sint Maarten, St Johns AG, Antigua, Fort-De-France, Martinique, Roseau, Dominica, Basseterre, St Kitts and Nevis, St Thomas, US Virgin Islands, Half Moon Cay, Bahamas, Miami, Florida
2026 Sails: Feb 27, More...
Cruises that depart from North America: United States: California: San Diego
Cruises that visit San Diego
Click on a cruise ship itinerary sailing from San Diego (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just San Diego), please visit: Cruise Search or try our Virtual Cruise Advisor™.
17 Night - Circle HawaiiStarting in San Diego, California, Kahului, Maui, Hilo, Hawaii, Kona, Hawaii, Honolulu, Hawaii, Nawiliwili, Kauai, Hawaii, Ensenada, Mexico, San Diego, California
2026 Sails: Jan 10, More...
7 Night - Mexican Riviera - San DiegoStarting in San Diego, Ca, Puerto Vallarta, Mexico, Mazatlan, Mexico, Cabo San Lucas, Mexico, San Diego, Ca
2026 Sails: Jan 10, Jan 24, Jan 31, More...
7 Night - Mexican Riviera - San DiegoStarting in San Diego, Ca, Cabo San Lucas, Mexico, Mazatlan, Mexico, Puerto Vallarta, Mexico, San Diego, Ca
2026 Sails: Jan 17, More...
18 Night - Circle HawaiiStarting in San Diego, California, Hilo, Hawaii, Kona, Hawaii, Kahului, Maui, Honolulu, Hawaii, Nawiliwili, Kauai, Hawaii, Ensenada, Mexico, San Diego, California
2026 Sails: Jan 27, More...
5 Night - Mexican Riviera - San DiegoStarting in San Diego, Ca, Cabo San Lucas, Mexico, San Diego, Ca
2026 Sails: Feb 7, More...
15 Night - Panama Canal-Panama CityStarting in San Diego, Ca, Cabo San Lucas, Mexico, Acapulco, Mexico, Puerto Quetzal, Guatemala, Puntarenas / Puerto Caldera, Costa Rica, Panama City, Panama, Transit Panama Canal / At Sea, Cartagena CO, Miami, Fl
2026 Sails: Feb 12, More...
35 Night - Hawaii, Tahiti & MarquesasStarting in San Diego, California, Kahului, Maui, Hilo, Hawaii, Honolulu, Hawaii, Nawiliwili, Kauai, Hawaii, Kona, Hawaii, Cross International Dateline, Tabuaeran (Fanning Island), Kiribati, Crossing the Equator, Cross International Dateline, Raiatea, Society Islands, French Polynesia, Papeete, French Polynesia, Bahia d Opunoha, Moorea, French Polynesia, Fakarava, Tuamotu, French Polynesia, Taiohae, Nuku Hiva, French Polynesia, Crossing the Equator, San Diego, California
2026 Sails: Feb 14, More...
27 Night - Historic Sea of Cortez & Panama CanalStarting in San Diego, California, Cabo San Lucas, Mexico, Pichilingue (La Paz), Mexico, Loreto, Mexico, Guaymas, Mexico, Topolobampo, Mexico, Mazatlan, Mexico, Puerto Vallarta, Mexico, Ensenada, Mexico, San Diego, California, Puerto Vallarta, Mexico, Huatulco, Mexico, Puerto Chiapas, Mexico, Puerto Quetzal, Guatemala, Fuerte Amador, Panama, Enter Panama Canal Balboa, Cruising Panama Canal, Exit Panama Canal Cristobal, Cartagena CO, Half Moon Cay, Bahamas, Miami, Florida
2026 Sails: Feb 15, More...
12 Night - Historical Baja PeninsulaStarting in San Diego, California, Cabo San Lucas, Mexico, Pichilingue (La Paz), Mexico, Loreto, Mexico, Guaymas, Mexico, Topolobampo, Mexico, Mazatlan, Mexico, Puerto Vallarta, Mexico, Ensenada, Mexico, San Diego, California
2026 Sails: Feb 15, More...
26 Night - Panama Canal & Eastern CaribbeanStarting in San Diego, California, Puerto Vallarta, Mexico, Huatulco, Mexico, Puerto Chiapas, Mexico, Puerto Quetzal, Guatemala, Fuerte Amador, Panama, Enter Panama Canal Balboa, Cruising Panama Canal, Exit Panama Canal Cristobal, Cartagena CO, Half Moon Cay, Bahamas, Miami, Florida, Philipsburg, Sint Maarten, St Johns AG, Antigua, Fort-De-France, Martinique, Roseau, Dominica, Basseterre, St Kitts and Nevis, St Thomas, US Virgin Islands, Half Moon Cay, Bahamas, Miami, Florida
2026 Sails: Feb 27, More...
