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San Diego Cruise Departures

Cruises that depart from North America: United States: California: San Diego

Cruises that visit San Diego

Click on a cruise ship itinerary sailing from San Diego (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just San Diego), please visit: Cruise Search or try our Virtual Cruise Advisor™.



Holland America, Zuiderdam
Zuiderdam26 Night - Panama Canal & Eastern Caribbean
Starting in San Diego, California, Puerto Vallarta, Mexico, Huatulco, Mexico, Puerto Chiapas, Mexico, Puerto Quetzal, Guatemala, Fuerte Amador, Panama, Enter Panama Canal Balboa, Cruising Panama Canal, Exit Panama Canal Cristobal, Cartagena CO, Half Moon Cay, Bahamas, Miami, Florida, Philipsburg, Sint Maarten, St Johns AG, Antigua, Fort-De-France, Martinique, Roseau, Dominica, Basseterre, St Kitts and Nevis, St Thomas, US Virgin Islands, Half Moon Cay, Bahamas, Miami, Florida
2026 Sails: Feb 27, More...
Holland America, Zuiderdam
Zuiderdam15 Night - Panama Canal
Starting in San Diego, California, Puerto Vallarta, Mexico, Huatulco, Mexico, Puerto Chiapas, Mexico, Puerto Quetzal, Guatemala, Fuerte Amador, Panama, Enter Panama Canal Balboa, Cruising Panama Canal, Exit Panama Canal Cristobal, Cartagena CO, Half Moon Cay, Bahamas, Miami, Florida
2026 Sails: Feb 27, More...
Disney Cruise Line, Disney Wonder
Disney Wonder4 Night - Baja Cruise from San Diego
Starting in San Diego, Catalina, Ensenada, San Diego
2026 Sails: Mar 2, Mar 23, Mar 30, Apr 13, More...
Disney Cruise Line, Disney Wonder
Disney Wonder3 Night - Baja Cruise from San Diego
Starting in San Diego, Catalina, Ensenada, San Diego
2026 Sails: Mar 6, Mar 13, Mar 20, Apr 3, Apr 10, Apr 17, May 1, More...
Disney Cruise Line, Disney Wonder
Disney Wonder4 Night - Baja Cruise from San Diego
Starting in San Diego, Catalina, Ensenada, San Diego
2026 Sails: Mar 9, Mar 16, Apr 6, Apr 20, More...
Disney Cruise Line, Disney Wonder
Disney Wonder3 Night - Baja Cruise from San Diego
Starting in San Diego, Ensenada, San Diego
2026 Sails: Mar 27, May 4, More...
Holland America, Nieuw Amsterdam
Nieuw Amsterdam14 Night - Baja Peninsula, Wine Country and Pnw
Starting in San Diego, California, Cabo San Lucas, Mexico, Pichilingue (La Paz), Mexico, Loreto, Mexico, San Diego, California, Avalon, California, San Francisco, California, Astoria, Oregon, Victoria CA, Canada, Vancouver, BC, CA
2026 Sails: Mar 28, More...
Holland America, Nieuw Amsterdam
Nieuw Amsterdam7 Night - Baja Peninsula
Starting in San Diego, California, Cabo San Lucas, Mexico, Pichilingue (La Paz), Mexico, Loreto, Mexico, San Diego, California
2026 Sails: Mar 28, More...
Norwegian Cruise Line, Norwegian Jade
Norwegian Jade7 Night - Mexican Riviera - San Diego
Starting in San Diego, Ca, Mazatlan, Mexico, Puerto Vallarta, Mexico, Cabo San Lucas, Mexico, San Diego, Ca
2026 Sails: Mar 28, More...
Nieuw Amsterdam7 Night - Wine Country & Pacific Northwest
Starting in San Diego, California, Avalon, California, San Francisco, California, Astoria, Oregon, Victoria CA, Canada, Vancouver, BC, CA
2026 Sails: Apr 4, More...

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San Diego Cruise Departures