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San Diego Cruise Departures

Cruises that depart from North America: United States: California: San Diego

Cruises that visit San Diego

Click on a cruise ship itinerary sailing from San Diego (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just San Diego), please visit: Cruise Search or try our Virtual Cruise Advisor™.



Crystal Cruises, Crystal Symphony
Crystal Symphony12 Night - The Americas & Caribbean
Starting in San Diego, Ensenada, Cabo San Lucas (Baja California Sur), Puerto Vallarta, Acajutla, Playa Flamingo, Puntarenas, Manta, Guayaquil
2026 Sails: Aug 24, More...
Crystal Cruises, Crystal Symphony
Crystal Symphony32 Night - The Americas & Caribbean
Starting in San Diego, Ensenada, Cabo San Lucas (Baja California Sur), Puerto Vallarta, Acajutla, Playa Flamingo, Puntarenas, Manta, Guayaquil, Fuerte Amador (Panama City), Panama Canal Transit, Cartagena CO, Santo Domingo, Punta Cana, San Juan, Marigot, St Martin, Roseau, Bridgetown, Castries, St Lucia, St Johns, Jost Van Dyke, British Virgin Islands, Samana, Grand Turk, New York
2026 Sails: Aug 24, More...
Disney Cruise Line, Disney Magic
Disney Magic4 Night - Baja Cruise from San Diego
Starting in San Diego, Ensenada, San Diego
2026 Sails: Sep 21, Oct 12, More...
Disney Cruise Line, Disney Magic
Disney Magic3 Night - Halloween On the High Seas Baja Cruise from San Diego
Starting in San Diego, Ensenada, San Diego
2026 Sails: Sep 25, Oct 9, More...
Disney Cruise Line, Disney Magic
Disney Magic3 Night - Halloween On the High Seas Baja Cruise from San Diego
Starting in San Diego, Ensenada, San Diego
2026 Sails: Sep 28, Oct 16, More...
Disney Cruise Line, Disney Magic
Disney Magic4 Night - Halloween On the High Seas Baja Cruise from San Diego
Starting in San Diego, Catalina, Ensenada, San Diego
2026 Sails: Oct 1, More...
Holland America, Nieuw Amsterdam
Nieuw Amsterdam16 Night - Panama Canal
Starting in San Diego, California, Puerto Vallarta, Mexico, Huatulco, Mexico, Puerto Chiapas, Mexico, Puerto Quetzal, Guatemala, Acajutla, El Salvador, Enter Panama Canal Balboa, Cruising Panama Canal, Exit Panama Canal Cristobal, Cartagena CO, RelaxAway, Half Moon Cay, Bahamas, Fort Lauderdale, Florida
2026 Sails: Oct 2, More...
Royal Caribbean, Serenade of the Seas
Serenade of the Seas2 Night - Ensenada Cruise
Starting in San Diego, California, Ensenada, Mexico, San Diego, California
2026 Sails: Oct 2, More...
Disney Cruise Line, Disney Wonder
Disney Wonder7 Night - Halloween On the High Seas Mexican Riviera Cruise from San Diego
Starting in San Diego, Puerto Vallarta, Cabo San Lucas, Ensenada, San Diego
2026 Sails: Oct 3, More...
MSC Cruises, MSC Poesia
MSC Poesia14 Night - Msc Grand Voyages
Starting in San Diego, Cabo San Lucas, Mexico, Puntarenas (San Jose), Costa Rica, Cruising Panama Canal, Colon, Panama, Cartagena CO, Miami, Florida
2026 Sails: Oct 3, More...

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San Diego Cruise Departures