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San Diego Cruise Departures

Cruises that depart from North America: United States: California: San Diego

Cruises that visit San Diego

Click on a cruise ship itinerary sailing from San Diego (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just San Diego), please visit: Cruise Search or try our Virtual Cruise Advisor™.



Disney Cruise Line, Disney Wonder
Disney Wonder3 Night - Baja Cruise from San Diego
Starting in San Diego, Catalina, Ensenada, San Diego
2026 Sails: Apr 17, May 1, More...
Holland America, Zaandam
Zaandam14 Night - Mexican Riviera & Baja Peninsula
Starting in San Diego, California, Cabo San Lucas, Mexico, Pichilingue (La Paz), Mexico, Loreto, Mexico, San Diego, California, Cabo San Lucas, Mexico, Mazatlan, Mexico, Puerto Vallarta, Mexico, San Diego, California
2026 Sails: Apr 18, More...
Disney Cruise Line, Disney Magic
Disney Magic4 Night - Baja Cruise from San Diego
Starting in San Diego, Catalina, Ensenada, San Diego
2026 Sails: Apr 19, More...
Disney Cruise Line, Disney Wonder
Disney Wonder4 Night - Baja Cruise from San Diego
Starting in San Diego, Catalina, Ensenada, San Diego
2026 Sails: Apr 20, More...
Holland America, Eurodam
Eurodam4 Night - Pacific Coastal Cruise
Starting in San Diego, California, Avalon, California, Vancouver, BC, CA
2026 Sails: Apr 20, More...
Disney Cruise Line, Disney Magic
Disney Magic4 Night - Baja Cruise from San Diego
Starting in San Diego, Ensenada, San Diego
2026 Sails: Apr 23, More...
Disney Cruise Line, Disney Wonder
Disney Wonder7 Night - Mexican Riviera Cruise from San Diego
Starting in San Diego, Puerto Vallarta, Cabo San Lucas, Ensenada, San Diego
2026 Sails: Apr 24, More...
Holland America, Zaandam
Zaandam11 Night - Mexican Riviera & Pacific Coast
Starting in San Diego, California, Cabo San Lucas, Mexico, Mazatlan, Mexico, Puerto Vallarta, Mexico, San Diego, California, Victoria CA, Canada, Vancouver, BC, CA
2026 Sails: Apr 25, More...
Holland America, Zaandam
Zaandam7 Night - Mexican Riviera
Starting in San Diego, California, Cabo San Lucas, Mexico, Mazatlan, Mexico, Puerto Vallarta, Mexico, San Diego, California
2026 Sails: Apr 25, More...

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San Diego Cruise Departures