Buffalo Cruise Departures

Cruises that depart from North America: United States: New York: Buffalo

Cruises that visit Buffalo

See all River Cruises that depart from Buffalo

Click on a cruise ship itinerary sailing from Buffalo (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just Buffalo), please visit: Cruise Search or try our Virtual Cruise Advisor™.

8 Night - Great Lakes & Thousand Islands Cruise
Starting in Buffalo, NY, Day of Cruising, Day of Cruising the Welland Canal, Rochester, NY, Clayton, NY, Day of Cruising, Ogdensburg, NY, Oswego, NY
2026 Sails: May 29, Aug 27, 2027: Jun 16, Aug 14, Sep 28, Oct 12, 2028: Jun 15, Aug 13, Sep 27, Oct 11, More...

American Cruise Lines, American Patriot

13 Night - American Great Lakes Cruise
Starting in Buffalo, NY, Day of Cruising, Toledo, OH, Detroit, MI, Day of Cruising, Alpena, MI, Day of Cruising, Sault Ste Marie, MI, Mackinac Island, MI, Day of Cruising, Muskegon, MI, Holland, MI, Milwaukee, WI
2026 Sails: Jun 12, Jul 20, 2027: May 9, Jun 30, Aug 28, 2028: May 8, Jun 29, Aug 27, More...