Portland ME Cruise Departures

Cruises that depart from North America: United States: Maine: Portland ME

Cruises that visit Portland ME

See all River Cruises that depart from Portland ME

Click on a cruise ship itinerary sailing from Portland ME (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just Portland ME), please visit: Cruise Search or try our Virtual Cruise Advisor™.

8 Night - Maine Coast & Harbors Cruise
Starting in Portland ME, Day of Cruising the Maine Coast, Bath, ME, Boothbay Harbor, ME, Rockland, ME / Camden, ME, Bar Harbor, Me, Bucksport, ME, Bangor ME
2027 Sails: May 28, Jun 11, Jun 25, Jul 9, Jul 23, Aug 6, Aug 20, Sep 3, 2028: May 7, May 21, Jun 4, Jun 18, Jul 2, Jul 16, Jul 30, Aug 13, Aug 27, More...

American Cruise Lines, American Independence

8 Night - Maine Coast & Harbors Cruise
Starting in Portland ME, Day of Cruising the Maine Coast, Bath, ME, Boothbay Harbor, ME, Rockland, ME / Camden, ME, Bar Harbor, Me, Bucksport, ME, Bangor ME
2027 Sails: Jun 7, Jun 21, Jul 5, Jul 19, Aug 2, Aug 16, Aug 30, 2028: Jul 28, Aug 11, Aug 25, Sep 8, More...

American Cruise Lines, American Maverick

8 Night - Maine Coast & Harbors Cruise
Starting in Portland ME, Day of Cruising the Maine Coast, Bath, ME, Boothbay Harbor, ME, Rockland, ME / Camden, ME, Bar Harbor, Me, Bucksport, ME, Bangor ME
2027 Sails: Jul 2, Jul 16, Jul 30, Aug 13, Aug 27, Sep 10, 2028: Jun 11, Jun 25, Jul 9, Jul 23, Aug 6, Aug 20, Sep 3, More...

American Cruise Lines, American Mariner

15 Night - New England Fall Foliage Cruise
Starting in Portland ME, Day of Cruising the Maine Coast, Bath, ME, Portsmouth NH, Gloucester, MA, Boston, Ma, Marthas Vineyard, MA, Nantucket Island, MA, Newport, Ri, Sag Harbor, NY, New London / Mystic, CT, Sleepy Hollow, NY, New York, NY
2027 Sails: Sep 17, 2028: Sep 10, More...

American Cruise Lines, American Maverick

Portland ME Cruise Departures