CruiseCompete.com
Travel Agents Competing To Offer The Best Cruise Deals
1
Find your cruise
& request quotes
2
Compare personalized offers
prices, upgrades, cabin credits & more
3
Contact your preferred agent
for questions or to book your cruise
Trusted by more than 1.5 million consumers since 2003.
Join Now
Charleston Cruise Departures

Cruises that depart from North America: United States: South Carolina: Charleston

Cruises that visit Charleston

See all River Cruises that depart from Charleston

Click on a cruise ship itinerary sailing from Charleston (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just Charleston), please visit: Cruise Search or try our Virtual Cruise Advisor™.

Charleston
Shore Excursions

American Cruise Lines, American Glory
American Glory8 Night - Southeast Sea Islands Cruise
Starting in Charleston, SC, Day of Cruising, Beaufort, SC, Hilton Head Island, SC, Savannah, GA, Cruising Intracoastal Waterway, Jekyll Island / St Simons Island, GA, Amelia Island, FL
2026 Sails: Feb 27, Mar 13, Mar 27, Apr 10, Nov 24, Dec 8, Dec 22, 2027: Feb 10, Feb 24, Mar 10, Mar 24, Apr 7, Apr 21, Nov 22, Dec 6, 2028: Feb 4, Feb 18, Mar 3, Mar 17, Mar 31, Apr 14, Dec 6, Dec 20, More...
American Cruise Lines, American Liberty
American Liberty8 Night - Southeast Sea Islands Cruise
Starting in Charleston, SC, Day of Cruising, Beaufort, SC, Hilton Head Island, SC, Savannah, GA, Cruising Intracoastal Waterway, Jekyll Island / St Simons Island, GA, Amelia Island, FL
2026 Sails: Mar 6, Mar 20, Apr 3, Apr 17, May 1, May 15, Nov 16, Nov 30, Dec 14, Dec 28, 2027: Feb 5, Feb 19, Mar 5, Mar 19, Apr 2, Apr 16, Apr 30, May 14, May 28, Jun 11, Aug 13, Aug 27, Sep 10, Sep 24, More...
American Cruise Lines, American Eagle
American Eagle8 Night - Southeast Sea Islands Cruise
Starting in Charleston, SC, Day of Cruising, Beaufort, SC, Hilton Head Island, SC, Savannah, GA, Cruising Intracoastal Waterway, Jekyll Island / St Simons Island, GA, Amelia Island, FL
2026 Sails: Mar 25, Apr 8, Apr 22, May 6, Oct 31, Nov 14, 2027: Mar 26, Apr 9, Apr 23, May 7, Nov 1, Nov 15, 2028: Jan 28, Feb 11, Feb 25, Mar 10, Mar 24, Apr 7, Apr 21, May 5, Nov 6, Nov 20, More...
American Cruise Lines, American Legend
American Legend8 Night - Southeast Sea Islands Cruise
Starting in Charleston, SC, Day of Cruising, Beaufort, SC, Hilton Head Island, SC, Savannah, GA, Cruising Intracoastal Waterway, Jekyll Island / St Simons Island, GA, Amelia Island, FL
2026 Sails: Nov 21, Dec 5, Dec 19, 2027: Feb 3, Feb 17, Mar 3, Mar 17, Nov 29, Dec 13, Dec 27, 2028: Feb 16, Mar 1, Dec 2, Dec 16, Dec 30, More...

Charleston Cruise Departures