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Louisville River Cruise Departures

River Cruises that depart from North America: United States: Kentucky: Louisville

River Cruises that visit Louisville

See all Cruises that depart from Louisville

Ohio River Cruises

Click on a cruise ship itinerary sailing from Louisville (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just Louisville), please visit: Cruise Search or try our Virtual Cruise Advisor™.

River cruises by river name


American Duchess Cruises8 Night - Special Edition Voyages - Rhythm of the Rivers - An American Music Festival Cruise from Louisville to Nashville (Clarksville)
Starting in Louisville, KY; with stops in Brandenburg, KY; Owensboro, KY; Henderson, KY; Paducah, KY; Dover, KY; Clarksville, TN
2021 Sails: Jun 20, 2022: May 14, More...
American Duchess Cruises8 Night - Tennessee And Cumberland Rivers - Soul of the South Cruise from Louisville to Nashville (Clarksville)
Starting in Louisville, KY; with stops in Brandenburg, KY; Owensboro, KY; Henderson, KY; Paducah, KY; Dover, KY; Clarksville, TN
2021 Sails: Jun 20, 2022: May 14, 2023: Jul 29, More...
American Queen Cruises8 Night - Special Edition Voyages - Holidays - Star-Spangled Cruise from Louisville to Pittsburgh
Starting in Louisville, KY; with stops in Madison, IN; Cincinnati, OH; Maysville, KY; Point Pleasant, WV; Marietta, OH; Pittsburgh, PA
2021 Sails: Jun 27, More...
American Queen Cruises8 Night - Ohio River Exploration Cruise from Louisville to Pittsburgh
Starting in Louisville, KY; with stops in Madison, IN; Cincinnati, OH; Maysville, KY; Point Pleasant, WV; Marietta, OH; Pittsburgh, PA
2021 Sails: Jun 27, 2022: Jul 31, More...
American Duchess Cruises8 Night - Special Edition Voyages - Culinary & Cocktails - American Culinary Experience Cruise from Louisville to St. Louis (Alton)
Starting in Louisville, KY; with stops in Brandenburg, KY; Owensboro, KY; Henderson, KY; Paducah, KY; Cape Girardeau, MO; St. Louis, MO (Alton)
2021 Sails: Jul 4, More...
American Duchess Cruises8 Night - Upper Mississippi River - Midwestern Passage Cruise from Louisville to St. Louis (Alton)
Starting in Louisville, KY; with stops in Brandenburg, KY; Owensboro, KY; Henderson, KY; Paducah, KY; Cape Girardeau, MO; St. Louis, MO (Alton)
2021 Sails: Jul 4, Sep 26, More...
American Queen Cruises8 Night - Special Edition Voyages - Special Events - Founders Cruise from Louisville to St. Louis (Alton)
Starting in Louisville, KY; with stops in Brandenburg, KY; Owensboro, KY; Henderson, KY; Paducah, KY; Cape Girardeau, MO; St. Louis, MO (Alton)
2021 Sails: Jul 11, 2022: Aug 14, More...
American Queen Cruises8 Night - Upper Mississippi River - Midwestern Passage Cruise from Louisville to St. Louis (Alton)
Starting in Louisville, KY; with stops in Brandenburg, KY; Owensboro, KY; Henderson, KY; Paducah, KY; Cape Girardeau, MO; St. Louis, MO (Alton)
2021 Sails: Jul 11, 2022: Aug 14, More...
American Queen Cruises8 Night - Special Edition Voyages - Rhythm of the Rivers - Music of the 50s and 60s Cruise from Louisville to Memphis
Starting in Louisville, KY; with stops in Brandenburg, KY; Owensboro, KY; Henderson, KY; Paducah, KY; New Madrid, MO; Ashport Landing, TN; Memphis, TN
2021 Sails: Aug 22, More...
American Duchess Cruises8 Night - Special Edition Voyages - Culinary & Cocktails - American Culinary Experience Cruise from Louisville to Memphis
Starting in Louisville, KY; with stops in Brandenburg, KY; Owensboro, KY; Henderson, KY; Paducah, KY; Cape Girardeau, MO; Ashport Landing, TN; Memphis, TN
2021 Sails: Aug 29, More...


Louisville River Cruise Departures

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