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Louisville River Cruise Departures

River Cruises that depart from North America: United States: Kentucky: Louisville

River Cruises that visit Louisville

See all Cruises that depart from Louisville

Ohio River Cruises

Click on a cruise ship itinerary sailing from Louisville (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just Louisville), please visit: Cruise Search or try our Virtual Cruise Advisor™.

River cruises by river name


American Duchess Cruises8 Night - Louisville to Nashville (Clarksville)
Starting in Louisville, KY; with stops in Brandenburg, KY; Owensboro, KY; Henderson, KY; Paducah, KY; Dover, KY; Clarksville, TN
2022 Sails: May 14, 2023: Jul 29, More...
American Countess Cruises8 Night - Louisville to Pittsburgh
Starting in Louisville, KY; with stops in Madison, IN; Cincinnati, OH; Maysville, KY; Point Pleasant, WV; Marietta, OH; Pittsburgh, PA
2022 Sails: May 30, Aug 29, 2023: May 22, Aug 7, More...
American Countess Cruises8 Night - The Art of Discovery River Cruise from Louisville to Memphi
Starting in Louisville, KY; with stops in Madison, IN; Brandenburg, KY; Owensboro, KY; Henderson, KY; Paducah, KY; New Madrid, MO; Memphis, TN
2022 Sails: Jun 13, More...
American Queen Cruises8 Night - Louisville to Nashville (Clarksville)
Starting in Louisville, KY; with stops in Brandenburg, KY; Owensboro, KY; Henderson, KY; Paducah, KY; Dover, TN; Clarksville, TN
2022 Sails: Jun 19, More...
American Countess Cruises8 Night - Star-Spangled Cruise from Louisville to Nashville (Clarksville)
Starting in Louisville, KY; with stops in Brandenburg, KY; Owensboro, KY; Henderson, KY; Paducah, KY; Dover, TN; Clarksville, TN
2022 Sails: Jun 27, More...
American Duchess Cruises8 Night - American Culinary Experience River Cruise from Louisville to Memphis
Starting in Louisville, KY; with stops in Brandenburg, KY; Owensboro, KY; Henderson, KY; Paducah, KY; Cape Girardeau, MO; Ashport Landing, TN; Memphis, TN
2022 Sails: Jul 9, Nov 5, More...
American Queen Cruises8 Night - Louisville to Pittsburgh
Starting in Louisville, KY; with stops in Madison, IN; Cincinnati, OH; Maysville, KY; Point Pleasant, WV; Marietta, OH; Pittsburgh, PA
2022 Sails: Jul 31, More...
American Queen Cruises8 Night - Founders Cruise from Louisville to St. Louis (Alton)
Starting in Louisville, KY; with stops in Brandenburg, KY; Owensboro, KY; Henderson, KY; Paducah, KY; Cape Girardeau, MO; St. Louis, MO (Alton)
2022 Sails: Aug 14, More...
American Queen Cruises8 Night - Midwestern Passage River Cruise from Louisville to St. Louis (Alton)
Starting in Louisville, KY; with stops in Brandenburg, KY; Owensboro, KY; Henderson, KY; Paducah, KY; Cape Girardeau, MO; St. Louis, MO (Alton)
2022 Sails: Aug 14, More...
American Duchess Cruises8 Night - Bourbon - An American Spirit River Cruise from Louisville to Nashville (Clarksville)
Starting in Louisville, KY; with stops in Madison, IN; Owensboro, KY; Henderson, KY; Paducah, KY; Dover, TN; Clarksville, TN
2022 Sails: Aug 20, More...


Louisville River Cruise Departures

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