St Paul River Cruise Departures

River Cruises that depart from North America: United States: Minnesota: St Paul

River Cruises that visit St Paul

See all Cruises that depart from St Paul

Mississippi River Cruises

Click on a cruise ship itinerary sailing from St Paul (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just St Paul), please visit: Cruise Search or try our Virtual Cruise Advisor™.

7 Night - Upper Mississippi River Cruise from St. Paul, MN to St. Louis, MO
Starting in St. Paul, MN; with stops in Red Wing, MN; Winona, MN; Dubuque, IA; Davenport, IA; Fort Madison, IA; Hannibal, MO; St. Louis, MO
2021 Sails: Jul 28, Sep 11, Sep 25, Oct 9, 2022: Jul 27, Sep 10, Sep 24, Oct 8, 2023: Jul 26, Sep 9, Sep 23, Oct 7, More...

American Cruise Lines, Queen of the Mississippi

American Cruise Lines, America

14 Night - Grand Heartland Cruise from St. Paul, MN to New Orleans, LA
Starting in St. Paul, MN; with stops in Red Wing, MN;Winona, MN; Dubuque, IA; Davenport, IA; Fort Madison, IA; Hannibal, MO; St. Louis, MO; Memphis, TN; Vicksburg, MS; Natchez, MS; Baton Rouge, LA; New Orleans, LA
2021 Sails: Aug 11, Oct 23, 2022: Aug 10, Oct 22, 2023: Aug 9, Oct 21, More...

American Cruise Lines, American Melody

7 Night - Upper Mississippi River Cruise from St. Paul, MN to St. Louis, MO
Starting in St. Paul, MN; with stops in Red Wing, MN; Winona, MN; Dubuque, IA; Davenport, IA; Fort Madison, IA; Hannibal, MO; St. Louis, MO
2021 Sails: Sep 24, Oct 8, Oct 22, 2022: Jul 1, Jul 15, Jul 29, Aug 12, Aug 26, Sep 9, Sep 23, Oct 7, Oct 21, 2023: Jun 30, Jul 14, Jul 28, Aug 11, Aug 25, Sep 8, Sep 22, Oct 6, Oct 20, More...

American Cruise Lines, American Melody

14 Night - Great Heartland Cruise from St. Paul, MN to New Orleans, LA
Starting in St. Paul, MN; with stops in Red Wing, MN; Winona, MN; Dubuque, IA; Davenport, IA; Fort Madison, IA; Hannibal, MO; St. Louis, MO; Memphis, TN; Vicksburg, MS; Natchez, MS; Baton Rouge, LA; New Orleans, LA
2021 Sails: Nov 5, 2022: Nov 4, 2023: Nov 3, More...

Viking River Cruises, Viking Mississippi

7 Night - America's Heartland - St. Paul to St. Louis
Starting in St. Paul with stops in Red Wing, La Crosse, Dubuque, Quad Cities, Burlington, Hannibal, St. Louis
2022 Sails: Sep 3, More...

Viking River Cruises, Viking Mississippi

14 Night - America's Great River - St. Paul to New Orleans
Starting in St. Paul with stops in Red Wing, La Crosse, Dubuque, Quad Cities, Burlington, Hannibal, St. Louis, Scenic Cruising: Lower Mississippi, Memphis, Vicksburg, Natchez, Baton Rouge, New Orleans
2022 Sails: Sep 17, Oct 15, More...

Viking River Cruises, Viking Mississippi

7 Night - America's Heartland - St. Paul to St. Louis
Starting in St. Paul with stops in Red Wing, La Crosse, Dubuque, Quad Cities, Burlington, Hannibal, St. Louis
2023 Sails: Aug 5, Aug 19, Sep 2, More...

St Paul River Cruise Departures