St Paul River Cruise Departures
River Cruises that depart from North America: United States: Minnesota: St Paul
See all Cruises that depart from St Paul
Mississippi River Cruises
River cruises by river name
8 Night - Upper Mississippi River Cruise
Starting in St Paul, MN, Cruising the Mississippi River, La Crosse, WI, Day of River Cruising, Dubuque, IA, Davenport, IA, Hannibal, MO, St Louis, MO / Alton, IL, Alton, IL / St Louis, MO
2026 Sails: Jun 12, Aug 21, Sep 4, Sep 18, Oct 2, 2027: Jun 25, Aug 6, Aug 20, Sep 3, Sep 17, Oct 1, 2028: Jun 23, Jul 8, Jul 21, Aug 4, Aug 19, Sep 1, Sep 15, More...
8 Night - Upper Mississippi River Cruise
Starting in St Paul, MN, Cruising the Mississippi River, La Crosse, WI, Day of River Cruising, Dubuque, IA, Davenport, IA, Hannibal, MO, St Louis, MO / Alton, IL, Alton, IL / St Louis, MO
2026 Sails: Jul 3, Jul 17, Jul 31, Aug 14, Aug 28, Sep 11, 2027: Jul 2, Jul 16, Jul 30, Aug 13, Aug 27, Sep 10, 2028: Jun 30, Jul 14, Jul 28, Aug 11, More...
14 Night - America's Great River
Starting in St Paul, Minnesota, Red Wing, Minnesota, La Crosse, Wisconsin, Dubuque, Iowa, Quad Cities, Iowa, Burlington, Iowa, Hannibal, Missouri, St Louis, Missouri, Scenic Sailing Lower Mississippi, Memphis, Tennessee, Greenville, Mississippi, Vicksburg, Mississippi, Natchez, Mississippi, Baton Rouge, Louisiana, New Orleans, Louisiana
2026 Sails: Jul 4, More...7 Night - Heartland of America
Starting in St Paul, Minnesota, Red Wing, Minnesota, La Crosse, Wisconsin, Dubuque, Iowa, Quad Cities, Iowa, Burlington, Iowa, Hannibal, Missouri, St Louis, Missouri (Alton)
2026 Sails: Aug 8, Aug 22, 2027: Aug 31, Sep 14, More...14 Night - America's Great River
Starting in St Paul, Minnesota, Red Wing, Minnesota, La Crosse, Wisconsin, Dubuque, Iowa, Quad Cities, Iowa, Burlington, Iowa, Hannibal, Missouri, St Louis, Missouri, Scenic Sailing Lower Mississippi, Memphis, Tennessee, Greenville, Mississippi, Vicksburg, Mississippi, Natchez, Mississippi, Baton Rouge, Louisiana, New Orleans, Louisiana
2026 Sails: Sep 5, 2027: Jul 27, Sep 28, More...
15 Night - Grand Heartland Cruise
Starting in St Paul, MN, Cruising the Mississippi River, La Crosse, WI, Dubuque, IA, Davenport, IA, Day of Cruising, Hannibal, MO, Day of River Cruising, St Louis, MO, Memphis, TN, Tunica, MS, Day of Cruising, Vicksburg, MS, Natchez, MS, Baton Rouge, LA, New Orleans, La
2026 Sails: Sep 11, More...15 Night - Grand Heartland Cruise
Starting in St Paul, MN, Cruising the Mississippi River, La Crosse, WI, Dubuque, IA, Davenport, IA, Day of Cruising, Hannibal, MO, Day of River Cruising, St Louis, MO, Memphis, TN, Tunica, MS, Day of Cruising, Vicksburg, MS, Natchez, MS, Baton Rouge, LA, New Orleans, La
2026 Sails: Sep 25, 2027: Sep 24, 2028: Aug 25, More...15 Night - Grand Heartland Cruise
Starting in St Paul, MN, Cruising the Mississippi River, La Crosse, WI, Dubuque, IA, Davenport, IA, Day of Cruising, Hannibal, MO, Day of River Cruising, St Louis, MO, Memphis, TN, Tunica, MS, Day of Cruising, Vicksburg, MS, Natchez, MS, Baton Rouge, LA, New Orleans, La
2026 Sails: Oct 16, 2027: Oct 15, 2028: Sep 29, More...
15 Night - Grand Heartland Cruise
Starting in St Paul, MN, Cruising the Mississippi River, La Crosse, WI, Dubuque, IA, Davenport, IA, Day of Cruising, Hannibal, MO, Day of River Cruising, St Louis, MO, Memphis, TN, Tunica, MS, Day of Cruising, Vicksburg, MS, Natchez, MS, Baton Rouge, LA, New Orleans, La
2027 Sails: Sep 17, 2028: Oct 18, More...
River Cruises that depart from North America: United States: Minnesota: St Paul
See all Cruises that depart from St Paul
Mississippi River Cruises
Click on a cruise ship itinerary sailing from St Paul (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just St Paul), please visit: Cruise Search or try our Virtual Cruise Advisor™.
River cruises by river name
8 Night - Upper Mississippi River CruiseStarting in St Paul, MN, Cruising the Mississippi River, La Crosse, WI, Day of River Cruising, Dubuque, IA, Davenport, IA, Hannibal, MO, St Louis, MO / Alton, IL, Alton, IL / St Louis, MO
2026 Sails: Jun 12, Aug 21, Sep 4, Sep 18, Oct 2, 2027: Jun 25, Aug 6, Aug 20, Sep 3, Sep 17, Oct 1, 2028: Jun 23, Jul 8, Jul 21, Aug 4, Aug 19, Sep 1, Sep 15, More...
8 Night - Upper Mississippi River CruiseStarting in St Paul, MN, Cruising the Mississippi River, La Crosse, WI, Day of River Cruising, Dubuque, IA, Davenport, IA, Hannibal, MO, St Louis, MO / Alton, IL, Alton, IL / St Louis, MO
2026 Sails: Jul 3, Jul 17, Jul 31, Aug 14, Aug 28, Sep 11, 2027: Jul 2, Jul 16, Jul 30, Aug 13, Aug 27, Sep 10, 2028: Jun 30, Jul 14, Jul 28, Aug 11, More...
14 Night - America's Great RiverStarting in St Paul, Minnesota, Red Wing, Minnesota, La Crosse, Wisconsin, Dubuque, Iowa, Quad Cities, Iowa, Burlington, Iowa, Hannibal, Missouri, St Louis, Missouri, Scenic Sailing Lower Mississippi, Memphis, Tennessee, Greenville, Mississippi, Vicksburg, Mississippi, Natchez, Mississippi, Baton Rouge, Louisiana, New Orleans, Louisiana
2026 Sails: Jul 4, More...
7 Night - Heartland of AmericaStarting in St Paul, Minnesota, Red Wing, Minnesota, La Crosse, Wisconsin, Dubuque, Iowa, Quad Cities, Iowa, Burlington, Iowa, Hannibal, Missouri, St Louis, Missouri (Alton)
2026 Sails: Aug 8, Aug 22, 2027: Aug 31, Sep 14, More...
14 Night - America's Great RiverStarting in St Paul, Minnesota, Red Wing, Minnesota, La Crosse, Wisconsin, Dubuque, Iowa, Quad Cities, Iowa, Burlington, Iowa, Hannibal, Missouri, St Louis, Missouri, Scenic Sailing Lower Mississippi, Memphis, Tennessee, Greenville, Mississippi, Vicksburg, Mississippi, Natchez, Mississippi, Baton Rouge, Louisiana, New Orleans, Louisiana
2026 Sails: Sep 5, 2027: Jul 27, Sep 28, More...
15 Night - Grand Heartland CruiseStarting in St Paul, MN, Cruising the Mississippi River, La Crosse, WI, Dubuque, IA, Davenport, IA, Day of Cruising, Hannibal, MO, Day of River Cruising, St Louis, MO, Memphis, TN, Tunica, MS, Day of Cruising, Vicksburg, MS, Natchez, MS, Baton Rouge, LA, New Orleans, La
2026 Sails: Sep 11, More...
15 Night - Grand Heartland CruiseStarting in St Paul, MN, Cruising the Mississippi River, La Crosse, WI, Dubuque, IA, Davenport, IA, Day of Cruising, Hannibal, MO, Day of River Cruising, St Louis, MO, Memphis, TN, Tunica, MS, Day of Cruising, Vicksburg, MS, Natchez, MS, Baton Rouge, LA, New Orleans, La
2026 Sails: Sep 25, 2027: Sep 24, 2028: Aug 25, More...
15 Night - Grand Heartland CruiseStarting in St Paul, MN, Cruising the Mississippi River, La Crosse, WI, Dubuque, IA, Davenport, IA, Day of Cruising, Hannibal, MO, Day of River Cruising, St Louis, MO, Memphis, TN, Tunica, MS, Day of Cruising, Vicksburg, MS, Natchez, MS, Baton Rouge, LA, New Orleans, La
2026 Sails: Oct 16, 2027: Oct 15, 2028: Sep 29, More...
15 Night - Grand Heartland CruiseStarting in St Paul, MN, Cruising the Mississippi River, La Crosse, WI, Dubuque, IA, Davenport, IA, Day of Cruising, Hannibal, MO, Day of River Cruising, St Louis, MO, Memphis, TN, Tunica, MS, Day of Cruising, Vicksburg, MS, Natchez, MS, Baton Rouge, LA, New Orleans, La
2027 Sails: Sep 17, 2028: Oct 18, More...
