Pennsylvania Cruise Departures
Cruises that depart from North America: United States: Pennsylvania
Cruises that visit Pennsylvania
See all River Cruises that depart from Pennsylvania
Related areas: Philadelphia : Pittsburgh
9 Night - Pre Philadelphia Cruisetour
Starting in At Hotel, Philadelphia, Pa, Royal Naval Dockyard, Bermuda, Charleston, SC, Philadelphia, Pa
2026 Sails: Apr 14, Apr 21, Apr 28, May 5, May 12, May 19, May 26, Jun 2, Jun 9, Jun 16, Jun 23, Jun 30, Jul 7, Jul 14, Jul 21, Jul 28, Aug 4, Aug 11, Aug 18, More...7 Night - Bermuda
Starting in Philadelphia, Pa, Royal Naval Dockyard, Bermuda, Charleston, SC, Philadelphia, Pa
2026 Sails: Apr 16, Apr 23, Apr 30, May 7, May 14, May 21, May 28, Jun 4, Jun 11, Jun 18, Jun 25, Jul 2, Jul 9, Jul 16, Jul 23, Jul 30, Aug 6, Aug 13, Aug 20, More...
8 Night - Ohio River Cruise
Starting in Pittsburgh, PA, Day of Cruising, Wheeling, WV, Marietta, OH, Day of Cruising, Cincinnati, OH, Madison, IN, Louisville, KY
2026 Sails: Jul 3, Jul 17, 2027: Jul 2, Jul 16, Jul 30, 2028: Jul 15, Jul 29, More...
8 Night - Ohio River Cruise
Starting in Pittsburgh, PA, Day of Cruising, Wheeling, WV, Marietta, OH, Day of Cruising, Cincinnati, OH, Madison, IN, Louisville, KY
2026 Sails: Jul 10, Jul 24, Aug 7, 2027: Jul 16, Jul 30, Aug 13, 2028: Jul 15, Jul 29, Aug 12, More...15 Night - Grand Ohio River Cruise
Starting in Pittsburgh, PA, Day of Cruising, Marietta, OH, Day of Cruising, Maysville, KY, Cincinnati, OH, Madison, IN, Louisville, KY, Day of Cruising, Henderson, KY / Evansville, IN, Day of Cruising, Paducah, KY, Day of Cruising, St Louis, MO
2026 Sails: Jul 31, 2027: Aug 13, 2028: Aug 12, More...15 Night - Grand Ohio River Cruise
Starting in Pittsburgh, PA, Day of Cruising, Marietta, OH, Day of Cruising, Maysville, KY, Cincinnati, OH, Madison, IN, Louisville, KY, Day of Cruising, Henderson, KY / Evansville, IN, Day of Cruising, Paducah, KY, Day of Cruising, St Louis, MO
2026 Sails: Aug 21, 2027: Aug 27, 2028: Aug 26, More...11 Night - Pre Philadelphia Cruisetour
Starting in At Hotel, Philadelphia, Pa, Royal Naval Dockyard, Bermuda, Charleston, SC, Philadelphia, Pa
2026 Sails: Aug 25, More...9 Night - Bermuda
Starting in Philadelphia, Pa, Royal Naval Dockyard, Bermuda, Charleston, SC, Philadelphia, Pa
2026 Sails: Aug 27, More...13 Night - Pre Philadelphia Cruisetour
Starting in At Hotel, Philadelphia, Pa, Boston, Ma, Bar Harbor, Me, Saint John NB (Bay of Fundy), Halifax, Canada, Sydney NS, Cape Breton Island, Canada, Charlottetown, Prince Edward Island, Canada, La Baie Saguenay River, Canada, Quebec City, Canada
2026 Sails: Sep 3, More...11 Night - Canada & New England
Starting in Philadelphia, Pa, Boston, Ma, Bar Harbor, Me, Saint John NB (Bay of Fundy), Halifax, Canada, Sydney NS, Cape Breton Island, Canada, Charlottetown, Prince Edward Island, Canada, La Baie Saguenay River, Canada, Quebec City, Canada
2026 Sails: Sep 5, More...
Cruises that depart from North America: United States: Pennsylvania
Cruises that visit Pennsylvania
See all River Cruises that depart from Pennsylvania
Click on a cruise ship itinerary sailing from Pennsylvania (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just Pennsylvania), please visit: Cruise Search or try our Virtual Cruise Advisor™.
Related areas: Philadelphia : Pittsburgh
9 Night - Pre Philadelphia CruisetourStarting in At Hotel, Philadelphia, Pa, Royal Naval Dockyard, Bermuda, Charleston, SC, Philadelphia, Pa
2026 Sails: Apr 14, Apr 21, Apr 28, May 5, May 12, May 19, May 26, Jun 2, Jun 9, Jun 16, Jun 23, Jun 30, Jul 7, Jul 14, Jul 21, Jul 28, Aug 4, Aug 11, Aug 18, More...
7 Night - BermudaStarting in Philadelphia, Pa, Royal Naval Dockyard, Bermuda, Charleston, SC, Philadelphia, Pa
2026 Sails: Apr 16, Apr 23, Apr 30, May 7, May 14, May 21, May 28, Jun 4, Jun 11, Jun 18, Jun 25, Jul 2, Jul 9, Jul 16, Jul 23, Jul 30, Aug 6, Aug 13, Aug 20, More...
8 Night - Ohio River CruiseStarting in Pittsburgh, PA, Day of Cruising, Wheeling, WV, Marietta, OH, Day of Cruising, Cincinnati, OH, Madison, IN, Louisville, KY
2026 Sails: Jul 3, Jul 17, 2027: Jul 2, Jul 16, Jul 30, 2028: Jul 15, Jul 29, More...
8 Night - Ohio River CruiseStarting in Pittsburgh, PA, Day of Cruising, Wheeling, WV, Marietta, OH, Day of Cruising, Cincinnati, OH, Madison, IN, Louisville, KY
2026 Sails: Jul 10, Jul 24, Aug 7, 2027: Jul 16, Jul 30, Aug 13, 2028: Jul 15, Jul 29, Aug 12, More...
15 Night - Grand Ohio River CruiseStarting in Pittsburgh, PA, Day of Cruising, Marietta, OH, Day of Cruising, Maysville, KY, Cincinnati, OH, Madison, IN, Louisville, KY, Day of Cruising, Henderson, KY / Evansville, IN, Day of Cruising, Paducah, KY, Day of Cruising, St Louis, MO
2026 Sails: Jul 31, 2027: Aug 13, 2028: Aug 12, More...
15 Night - Grand Ohio River CruiseStarting in Pittsburgh, PA, Day of Cruising, Marietta, OH, Day of Cruising, Maysville, KY, Cincinnati, OH, Madison, IN, Louisville, KY, Day of Cruising, Henderson, KY / Evansville, IN, Day of Cruising, Paducah, KY, Day of Cruising, St Louis, MO
2026 Sails: Aug 21, 2027: Aug 27, 2028: Aug 26, More...
11 Night - Pre Philadelphia CruisetourStarting in At Hotel, Philadelphia, Pa, Royal Naval Dockyard, Bermuda, Charleston, SC, Philadelphia, Pa
2026 Sails: Aug 25, More...
9 Night - BermudaStarting in Philadelphia, Pa, Royal Naval Dockyard, Bermuda, Charleston, SC, Philadelphia, Pa
2026 Sails: Aug 27, More...
13 Night - Pre Philadelphia CruisetourStarting in At Hotel, Philadelphia, Pa, Boston, Ma, Bar Harbor, Me, Saint John NB (Bay of Fundy), Halifax, Canada, Sydney NS, Cape Breton Island, Canada, Charlottetown, Prince Edward Island, Canada, La Baie Saguenay River, Canada, Quebec City, Canada
2026 Sails: Sep 3, More...
11 Night - Canada & New EnglandStarting in Philadelphia, Pa, Boston, Ma, Bar Harbor, Me, Saint John NB (Bay of Fundy), Halifax, Canada, Sydney NS, Cape Breton Island, Canada, Charlottetown, Prince Edward Island, Canada, La Baie Saguenay River, Canada, Quebec City, Canada
2026 Sails: Sep 5, More...
