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Pennsylvania Cruise Departures

Cruises that depart from North America: United States: Pennsylvania

Cruises that visit Pennsylvania

See all River Cruises that depart from Pennsylvania

Click on a cruise ship itinerary sailing from Pennsylvania (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just Pennsylvania), please visit: Cruise Search or try our Virtual Cruise Advisor™.

Related areas: Philadelphia : Pittsburgh


Norwegian Cruise Line, Norwegian Jewel
Norwegian Jewel7 Night - Bermuda
Starting in Philadelphia, Pa, Royal Naval Dockyard, Bermuda, Charleston, SC, Philadelphia, Pa
2026 Sails: Apr 16, Apr 23, Apr 30, May 7, May 14, May 21, May 28, Jun 4, Jun 11, Jun 18, Jun 25, More...
Norwegian Line Tours, Norwegian Jewel Tours
Norwegian Jewel Tours9 Night - Pre Philadelphia Cruisetour
Starting in At Hotel, Philadelphia, Pa, Royal Naval Dockyard, Bermuda, Charleston, SC, Philadelphia, Pa
2026 Sails: Jun 2, Jun 9, Jun 16, More...
Norwegian Line Tours, Norwegian Jewel Tours
Norwegian Jewel Tours9 Night - Pre Philadelphia Cruisetour
Starting in At Hotel, Philadelphia, Pa, Royal Naval Dockyard, Bermuda, Halifax, Canada, Philadelphia, Pa
2026 Sails: Jun 30, Jul 7, Jul 21, Jul 28, More...
Norwegian Cruise Line, Norwegian Jewel
Norwegian Jewel7 Night - Bermuda
Starting in Philadelphia, Pa, Royal Naval Dockyard, Bermuda, Halifax, Canada, Philadelphia, Pa
2026 Sails: Jul 2, Jul 9, Jul 16, Jul 23, Jul 30, Aug 6, Aug 13, Aug 20, More...
American Cruise Lines, American Melody
American Melody8 Night - Ohio River Cruise
Starting in Pittsburgh, PA, Day of Cruising, Wheeling, WV, Marietta, OH, Day of Cruising, Cincinnati, OH, Madison, IN, Louisville, KY
2026 Sails: Jul 3, Jul 17, More...
American Cruise Lines, American Heritage
American Heritage8 Night - Ohio River Cruise
Starting in Pittsburgh, PA, Day of Cruising, Wheeling, WV, Marietta, OH, Day of Cruising, Cincinnati, OH, Madison, IN, Louisville, KY
2026 Sails: Jul 10, Jul 24, Aug 7, More...
American Cruise Lines, American Melody
American Melody15 Night - Grand Ohio River Cruise
Starting in Pittsburgh, PA, Day of Cruising, Marietta, OH, Day of Cruising, Maysville, KY, Cincinnati, OH, Madison, IN, Louisville, KY, Day of Cruising, Henderson, KY / Evansville, IN, Day of Cruising, Paducah, KY, Day of Cruising, St Louis, MO
2026 Sails: Jul 31, 2027: Jul 16, More...
American Cruise Lines, American Heritage
American Heritage15 Night - Grand Ohio River Cruise
Starting in Pittsburgh, PA, Day of Cruising, Marietta, OH, Day of Cruising, Maysville, KY, Cincinnati, OH, Madison, IN, Louisville, KY, Day of Cruising, Henderson, KY / Evansville, IN, Day of Cruising, Paducah, KY, Day of Cruising, St Louis, MO
2026 Sails: Aug 21, More...
Norwegian Cruise Line, Norwegian Jewel
Norwegian Jewel9 Night - Bermuda
Starting in Philadelphia, Pa, Royal Naval Dockyard, Bermuda, Saint John NB (Bay of Fundy), Halifax, Canada, Philadelphia, Pa
2026 Sails: Aug 27, More...
Norwegian Line Tours, Norwegian Jewel Tours
Norwegian Jewel Tours13 Night - Pre Philadelphia Cruisetour
Starting in At Hotel, Philadelphia, Pa, Boston, Ma, Bar Harbor, Me, Saint John NB (Bay of Fundy), Halifax, Canada, Sydney NS, Cape Breton Island, Canada, Charlottetown, Prince Edward Island, Canada, La Baie Saguenay River, Canada, Quebec City, Canada
2026 Sails: Sep 3, More...

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Pennsylvania Cruise Departures