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Pennsylvania Cruise Departures

Cruises that depart from North America: United States: Pennsylvania

Cruises that visit Pennsylvania

See all River Cruises that depart from Pennsylvania

Click on a cruise ship itinerary sailing from Pennsylvania (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just Pennsylvania), please visit: Cruise Search or try our Virtual Cruise Advisor™.

Related areas: Philadelphia : Pittsburgh

Queen of the Mississippi Cruises10 Night - Ohio River Cruise from Pittsburgh, PA to St. Louis
Starting in Pittsburgh, PA; with stops in Marietta, OH; Maysville, KY; Cincinnati, OH; Louisville, KY; Henderson, KY; Paducah, KY; Cape Girardeau, MO; St. Louis, MO
2020 Sails: Aug 12, 2021: Aug 20, Sep 9, Sep 29, More...
American Duchess Cruises8 Night - Lewis and Clark Cruise from Pittsburgh to Louisville
Starting in Pittsburgh; with stops in Wheeling, WV; Marietta, OH; Huntington, WV; Augusta, KY; Cincinnati, OH; Madison, IN; Louisville, KY
2020 Sails: Sep 6, More...
Grande Mariner Cruises9 Night - Historic Chesapeake Bay from Philadelphia to Baltimore
Starting in Philadelphia; with stops in Annapolis; Alexandria; Yorktown; Norfolk; Crisfield; Cambridge; Oxford; St. Michaels; Baltimore
2021 Sails: May 13, More...

Pennsylvania Cruise Departures

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