Florida Cruise Departures

Cruises that depart from North America: United States: Florida

Cruises that visit Florida

See all River Cruises that depart from Florida

Click on a cruise ship itinerary sailing from Florida (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just Florida), please visit: Cruise Search or try our Virtual Cruise Advisor™.

American Cruise Lines, American Liberty

8 Night - Southeast Sea Islands Cruise
Starting in Amelia Island, FL, Day of Cruising, Jekyll Island / St Simons Island, GA, Cruising Intracoastal Waterway, Savannah, GA, Hilton Head Island, SC, Beaufort, SC, Charleston, SC
2026 Sails: Apr 10, Apr 24, May 8, Nov 9, Nov 23, Dec 7, Dec 21, 2027: Jan 29, Feb 12, Feb 26, Mar 12, Mar 26, Apr 9, Apr 23, May 7, May 21, Jun 4, Aug 6, Aug 20, Sep 3, Sep 17, Oct 1, Oct 15, Oct 29, More...

American Cruise Lines, American Pioneer

15 Night - Grand Florida Coast & Keys Cruise
Starting in Amelia Island, FL, Day of Cruising, Green Cove Springs, FL, St Augustine, FL, Cruising the Tolomato River, Cape Canaveral, FL, Day of Cruising, West Palm Beach, FL, Key Biscayne, FL, Key West, FL, Day of Cruising, Marco Island, FL, Punta Gorda, FL, St Petersburg FL
2026 Sails: Apr 10, Oct 30, More...

Celebrity Cruises, Celebrity Reflection

3 Night - Bahamas & Perfect Day Cruise
Starting in Fort Lauderdale, Florida, Bimini, Bahamas, Perfect Day Cococay, Bahamas, Fort Lauderdale, Florida
2026 Sails: Apr 10, More...

Disney Cruise Line, Disney Dream

3 Night - Bahamian Cruise from Fort Lauderdale
Starting in Port Everglades, Disney Lookout Cay, Nassau, Port Everglades
2026 Sails: Apr 10, Apr 17, Apr 24, More...

Disney Cruise Line, Disney Wish

3 Night - Bahamian Cruise from Port Canaveral
Starting in Port Canaveral, Nassau, Castaway Cay, Port Canaveral
2026 Sails: Apr 10, Apr 17, Apr 24, May 1, May 8, May 15, May 22, May 29, Jun 5, Jun 12, Jun 26, Jul 3, Jul 10, Jul 17, Jul 24, Jul 31, Aug 7, Aug 14, Aug 21, Aug 28, Sep 4, Sep 11, Sep 18, Sep 25, More...

Holland America, Koningsdam

22 Night - Panama Canal
Starting in Fort Lauderdale, Florida, Cartagena CO, Enter Panama Canal Cristobal, Cruising Panama Canal, Exit Panama Canal Balboa, Fuerte Amador, Panama, Puntarenas (Puerto Caldera), Costa Rica, Acajutla, El Salvador, Puerto Quetzal, Guatemala, Puerto Chiapas, Mexico, Manzanillo, Mexico, Puerto Vallarta, Mexico, San Diego, California, San Francisco, California, Vancouver, BC, CA
2026 Sails: Apr 10, More...

Holland America, Koningsdam

17 Night - Panama Canal
Starting in Fort Lauderdale, Florida, Cartagena CO, Enter Panama Canal Cristobal, Cruising Panama Canal, Exit Panama Canal Balboa, Fuerte Amador, Panama, Puntarenas (Puerto Caldera), Costa Rica, Acajutla, El Salvador, Puerto Quetzal, Guatemala, Puerto Chiapas, Mexico, Manzanillo, Mexico, Puerto Vallarta, Mexico, San Diego, California
2026 Sails: Apr 10, More...

Margaritaville at Sea, Margaritaville Islander

5 Night - Mexico Duo
Starting in Port Tampa Bay, Cozumel, Mexico, Progreso, Mexico, Port Tampa Bay
2026 Sails: Apr 10, May 9, May 18, Jun 1, Jul 13, Aug 10, Nov 20, 2027: Jan 16, Mar 4, Mar 13, Mar 18, Mar 27, Apr 10, Apr 24, May 3, May 17, May 31, Jun 28, Jul 12, Aug 9, Sep 27, Nov 18, Dec 2, More...

Margaritaville at Sea, Margaritaville Paradise

3 Night - Nassau Escape
Starting in Port of Palm Beach, Nassau, Bahamas, Port of Palm Beach
2026 Sails: Apr 10, Apr 17, Apr 24, May 15, May 22, May 29, Jun 5, Jun 12, Jun 19, Jun 26, Jul 3, Jul 10, Jul 17, Jul 24, Jul 31, Aug 7, Aug 14, Aug 21, Aug 28, Aug 31, Sep 11, Sep 18, Sep 25, Oct 9, More...

MSC Cruises, MSC Seaside

3 Night - Caribbean and Antilles
Starting in Miami, Florida, Nassau, Bahamas, Ocean Cay Msc Marine Reserve, Bahamas, Miami, Florida
2026 Sails: Apr 10, Apr 17, Apr 24, May 1, May 8, May 15, May 22, May 29, Jun 5, Jun 12, Jun 19, Jun 26, Jul 3, Jul 10, Jul 17, Jul 24, Jul 31, Aug 7, Aug 14, Aug 21, Aug 28, Sep 4, Sep 11, Sep 18, More...

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