Pittsburgh River Cruise Departures

River Cruises that depart from North America: United States: Pennsylvania: Pittsburgh

River Cruises that visit Pittsburgh

See all Cruises that depart from Pittsburgh

Ohio River Cruises

Click on a cruise ship itinerary sailing from Pittsburgh (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just Pittsburgh), please visit: Cruise Search or try our Virtual Cruise Advisor™.

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8 Night - Pittsburgh to Louisville
Starting in Pittsburgh, PA; with stops in Wheeling, WV; Marietta, OH; Huntington, WV; Augusta, KY; Cincinnati, OH; Madison, IN; Louisville, KY
2022 Sails: Jun 6, Sep 5, 2023: May 29, Aug 14, More...

American Queen Voyages, American Queen

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American Cruise Lines, Queen of the Mississippi

10 Night - Ohio River Cruise from Pittsburgh, PA to St. Louis
Starting in Pittsburgh, PA; with stops in Marietta, OH; Maysville, KY; Cincinnati, OH; Louisville, KY; Henderson, KY; Paducah, KY; Cape Girardeau, MO; St. Louis, MO
2022 Sails: Aug 16, Sep 5, Sep 25, 2023: Aug 15, Sep 4, Sep 24, More...

American Queen Voyages, American Duchess

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8 Night - Pittsburgh to Louisville
Starting in Pittsburgh, PA; with stops in Wheeling, WV; Marietta, OH; Huntington, WV; Augusta, KY; Cincinnati, OH; Madison, IN; Louisville, KY
2022 Sails: Oct 29, 2023: Jul 8, Jul 22, Oct 21, More...

Pittsburgh River Cruise Departures