Pittsburgh River Cruise Departures

River Cruises that depart from North America: United States: Pennsylvania: Pittsburgh

River Cruises that visit Pittsburgh

Ohio River Cruises

Click on a river cruise ship itinerary sailing from Pittsburgh (below) and select a sail date to receive competing cruise quotes. To search all river cruise itineraries (not just Pittsburgh), please visit: Cruise Search or try our Virtual Cruise Advisor™.

River cruises by river name

American Cruise Lines, Queen of the Mississippi

10 Night Ohio River Cruise from Pittsburgh, PA to St. Louis
Starting in Pittsburgh, PA; with stops in Marietta, OH; Maysville, KY; Cincinnati, OH; Louisville, KY; Henderson, KY; Paducah, KY; Cape Girardeau, MO; St. Louis, MO
2019 Sails: Jul 5, Jul 25, 2020: Jul 3, Jul 23, More...

American Queen Steamboat Company, American Duchess

8 Night Ohio and Tennessee River Lewis and Clark Cruise from Pittsburgh to Louisville
Starting in Pittsburgh; with stops in Wheeling, WV; Marietta, OH; Huntington, WV; Augusta, KY; Cincinnati, OH; Madison, IN; Louisville, KY
2019 Sails: Jul 21, More...

American Queen Steamboat Company, American Countess

7 Night Ohio River Sojourn from Pittsburgh to Louisville
Starting in Pittsburgh; with stops in Wheeling, WV; Marietta, OH; Huntington, WV; Augusta, KY; Cincinnati, OH; Madison, IN; Louisville, KY
2020 Sails: Jun 14, Jun 28, More...

American Queen Steamboat Company, American Duchess

8 Night Lewis and Clark Cruise from Pittsburgh to Louisville
Starting in Pittsburgh; with stops in Wheeling, WV; Marietta, OH; Huntington, WV; Augusta, KY; Cincinnati, OH; Madison, IN; Louisville, KY
2020 Sails: Sep 6, More...

Pittsburgh River Cruise Departures