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United States River Cruise Departures

River Cruises that depart from North America: United States

River Cruises that visit United States

See all Cruises that depart from United States

Click on a cruise ship itinerary sailing from United States (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just United States), please visit: Cruise Search or try our Virtual Cruise Advisor™.

River cruises by river name

Related areas: Florida : Georgia : Illinois : Kentucky : Louisiana : Maine : Massachusetts : Michigan : Minnesota : Missouri : Ohio : Oregon : Pennsylvania : Tennessee : Washington


American Song Cruises10 Night - Northwest Pioneers Cruise from Portland, OR to Clarkston, WA
Starting in Portland, OR; with stops in Astoria, OR; Mount St. Helens, WA; Hayden Island, OR; Stevenson, WA; Hood River, OR; The Dalles, OR; Richland, WA; Pendleton, OR; Clarkston, WA
2021 Sails: Apr 15, Jul 1, Sep 29, 2022: Apr 14, Jun 30, Sep 29, 2023: Jun 29, More...
Queen of the Mississippi Cruises7 Night - Lower Mississippi River Cruise from Memphis, TN to New Orleans, LA
Starting in Memphis TN; with stops in Vicksburg, MS; Natchez, MS; St. Francisville, LA; Baton Rouge, LA; Oak Valley, LA; New Orleans, LA
2021 Sails: Apr 17, May 1, May 15, May 29, Jun 12, Jun 26, Jul 10, Nov 20, Dec 4, 2022: Mar 5, Mar 19, Apr 2, Apr 16, Apr 30, May 14, May 28, Jun 11, Jun 25, Jul 9, Oct 22, Nov 5, Nov 19, Dec 3, 2023: Mar 4, More...
American Countess Cruises8 Night - Lower Mississippi River - Charms of the South Cruise from New Orleans to Memphis
Starting in New Orleans, LA; with stops in Nottoway; St. Francisville, LA; Natchez, MS; Vicksburg, MS; Port of the Mississippi Delta; Memphis, TN
2021 Sails: Apr 17, May 1, May 15, Jun 26, Jul 10, Jul 24, Aug 7, Sep 11, Oct 23, 2022: Mar 14, Mar 28, Apr 11, Oct 10, Nov 14, 2023: Mar 20, Apr 3, Apr 17, Sep 18, Nov 6, More...
American Jazz Cruises7 Night - Lower Mississippi River Cruise from New Orleans, LA to Memphis, TN
Starting in New Orleans, LA; with stops in Oak Alley, LA; Baton Rouge, LA; St. Francisville, LA; Natchez, MS; Vicksburg, MS; Memphis, TN
2021 Sails: Apr 18, May 2, May 16, May 30, Jun 13, Jun 27, Oct 10, Oct 24, Nov 7, Nov 21, Dec 5, Dec 20, 2022: Feb 20, Mar 6, Mar 20, Apr 3, Apr 17, May 1, May 15, May 29, Jun 12, Jun 26, Oct 9, Oct 23, More...
American Duchess Cruises8 Night - Special Edition Voyages - Culinary & Cocktails - American Culinary Experience Cruise from St. Louis to Cincinnati
Starting in St. Louis, MO; with stops in Alton, IL; Cape Girardeau, MO; Paducah, KY; Henderson, KY; Louisville, KY; Madison, IN; Cincinnati, OH
2021 Sails: Apr 18, More...
American Duchess Cruises8 Night - Ohio River - The Masterful Midwest Cruise from St. Louis to Cincinnati
Starting in St. Louis, MO; with stops in Alton, IL; Cape Girardeau, MO; Paducah, KY; Henderson, KY; Louisville, KY; Madison, IN; Cincinnati, OH
2021 Sails: Apr 18, More...
American Empress Cruises8 Night - Columbia and Snake River Cruises - Pacific Northwest Splendor Cruise from Spokane (Clarkston) to Portland (Vancouver, WA)
Starting in Spokane, WA; with stops in Clarkston, WA; Richland, WA; The Dalles, OR; Stevenson, WA; Astoria, OR; Vancouver, WA
2021 Sails: Apr 18, May 2, May 16, May 30, Jun 13, Jun 27, Jul 11, Jul 25, Aug 8, Aug 22, Sep 5, Sep 19, Oct 3, Oct 17, 2022: Mar 20, Apr 3, Apr 17, May 1, May 15, May 29, Jun 12, Jun 26, Jul 10, Jul 24, More...
America Cruises7 Night - Mississippi River Cruise Roundtrip from New Orleans, LA
Starting in New Orleans, LA; with stops in Oak Alley, LA; Natchez, MS; Vicksburg, MS; St. Francisville, LA; Baton Rouge, LA; Houmas House, LA; New Orleans, LA
2021 Sails: Apr 20, Apr 27, May 4, May 11, May 18, May 25, Jun 1, Jun 8, Jun 15, Jun 22, Nov 6, Nov 21, 2022: Feb 20, Feb 27, Mar 6, Mar 13, Apr 5, Apr 12, Apr 19, Apr 26, May 3, May 10, May 17, May 24, More...
American Harmony Cruises7 Night - Columbia and Snake River Cruise from Portland, OR to Clarkston, WA
Starting in Portland, OR; with stops in Astoria, OR; Mount St. Helens, WA; Cruising the Columbia River Gorge; Stevenson, WA; The Dalles, OR; Pendleton, OR; Richland, WA; Clarkston, WA
2021 Sails: Apr 21, May 5, May 19, Jun 2, Jun 16, Jun 30, Jul 14, Jul 28, Aug 11, Aug 25, Sep 8, Sep 22, Oct 6, Oct 20, Nov 3, Nov 17, 2022: Mar 3, Mar 17, Mar 31, May 5, May 19, Jun 2, Jun 16, Jul 21, More...
American Pride Cruises7 Night - Columbia and Snake Rivers Cruise from Clarkston, WA to Portland, OR
Starting in Clarkston, WA; with stops in Pendleton, OR; Richland, WA; The Dalles, OR; Cruising the Columbia River Gorge; Stevenson, WA; Mount St. Helens, WA; Astoria, OR; Portland, OR
2021 Sails: Apr 23, May 7, May 21, Jun 4, Jun 18, Jul 9, Jul 23, Aug 6, Aug 20, Sep 3, Sep 17, Oct 1, Oct 15, Oct 29, Nov 12, Nov 26, 2022: Apr 22, May 6, May 20, Jun 3, Jun 17, Jul 8, Jul 22, Aug 5, More...


United States River Cruise Departures

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