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United States River Cruise Departures

River Cruises that depart from North America: United States

River Cruises that visit United States

See all Cruises that depart from United States

Click on a cruise ship itinerary sailing from United States (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just United States), please visit: Cruise Search or try our Virtual Cruise Advisor™.

River cruises by river name

Related areas: Illinois : Kentucky : Louisiana : Minnesota : Missouri : Ohio : Oregon : Pennsylvania : Tennessee : Washington


American Harmony Cruises7 Night - Columbia and Snake River Cruise from Clarkston, WA to Portland, OR
Starting in Clarkston, WA; with stops in Pendleton, OR; Richland, WA; The Dalles, OR; Cruising the Columbia River Gorge; Stevenson, WA; Mount St. Helens, WA; Astoria, OR; Portland, OR
2021 Sails: Oct 27, Nov 10, Nov 24, 2022: Mar 10, Mar 24, Apr 7, Apr 28, May 12, May 26, Jun 9, Jun 23, Jul 14, Jul 28, Aug 11, Aug 25, Sep 8, Sep 22, Oct 13, Oct 27, Nov 10, 2023: Mar 2, Mar 16, Mar 30, Apr 13, More...
Queen of the West Cruises4 Night - Highlights of the Columbia River Cruise Roundtrip from Portland, OR
Starting in Portland, OR; with stops in Astoria, OR; Mount St. Helens, WA; Stevenson, WA; Portland, OR
2021 Sails: Oct 28, Nov 1, 2022: Jun 4, Jun 8, Jun 13, Jun 17, Jun 21, Oct 15, Oct 19, Oct 23, Oct 27, Oct 31, 2023: Jun 3, Jun 7, Jun 12, Jun 16, Jun 20, More...
American Melody Cruises7 Night - Upper Mississippi River Cruise from St. Louis, MO to St. Paul, MN
Starting in St. Louis, MO; with stops in Hannibal, MO; Fort Madison, IA; Davenport, IA; Dubuque, IA; Winona, MN; Red Wing, MN; St. Paul, MN
2021 Sails: Oct 29, 2022: Jul 8, Jul 22, Aug 5, Aug 19, Sep 2, Sep 16, Sep 30, Oct 14, Oct 28, More...
American Pride Cruises7 Night - Columbia and Snake Rivers Cruise from Clarkston, WA to Portland, OR
Starting in Clarkston, WA; with stops in Pendleton, OR; Richland, WA; The Dalles, OR; Cruising the Columbia River Gorge; Stevenson, WA; Mount St. Helens, WA; Astoria, OR; Portland, OR
2021 Sails: Oct 29, Nov 12, Nov 26, 2022: Apr 22, May 6, May 20, Jun 3, Jun 17, Jul 8, Jul 22, Aug 5, Aug 19, Sep 2, Sep 16, Oct 7, Oct 21, Nov 4, 2023: Mar 10, Mar 24, Apr 7, Apr 21, May 5, May 19, Jun 2, More...
Queen of the Mississippi Cruises7 Night - New Orleans Roundtrip Cruise from New Orleans, LA
Starting in New Orleans, LA; with stops in Oak Alley, LA; Natchez, MS; Vicksburg, MS; St. Francisville, LA; Baton Rouge, LA; Houmas House, LA; New Orleans, LA
2021 Sails: Oct 30, Nov 6, Dec 20, Dec 28, 2022: Jul 16, Dec 21, Dec 29, 2023: Jul 15, More...
American Countess Cruises8 Night - Civil War: A Historical Perspective River Cruise from Memphis to Chattanooga
Starting in Memphis, TN; with stops in New Madrid, MO; Paducah, KY; Savannah, TN; Decatur, AL; Chattanooga, TN
2021 Sails: Oct 30, More...
American Jazz Cruises7 Night - Lower Mississippi River Cruise from Memphis, TN to New Orleans, LA
Starting in Memphis TN; with stops in Vicksburg, MS; Natchez, MS; St. Francisville, LA; Baton Rouge, LA; Oak Valley, LA; New Orleans, LA
2021 Sails: Oct 31, Nov 14, Nov 28, Dec 12, Dec 28, 2022: Feb 27, Mar 13, Mar 27, Apr 10, Apr 24, May 8, May 22, Jun 5, Jun 19, Sep 25, Oct 16, Oct 30, Nov 13, Nov 27, 2023: Feb 26, Mar 12, Mar 26, Apr 9, Apr 23, More...
American Song Cruises7 Night - Columbia and Snake Rivers Cruise from Portland, OR to Clarkston, WA
Starting in Portland, OR; with stops in Astoria, OR; Mount St. Helens, WA; Cruising the Columbia River Gorge; Stevenson, WA; The Dalles, OR; Pendleton, OR; Richland, WA; Clarkston, WA
2021 Sails: Oct 31, 2022: Mar 13, Mar 27, May 1, May 15, May 29, Jun 12, Jul 17, Jul 31, Aug 14, Aug 28, Sep 11, Oct 16, Oct 30, Nov 13, 2023: Mar 5, Mar 19, Apr 2, Apr 16, Apr 30, May 14, May 28, Jun 11, Jul 16, More...
American Duchess Cruises8 Night - New Orleans to Memphis
Starting in New Orleans, LA; with stops in Nottoway; St. Francisville, LA; Natchez, MS; Vicksburg, MS; Port of the Mississippi Delta; Memphis, TN
2021 Sails: Oct 31, Nov 28, 2022: Mar 19, Apr 2, Apr 16, Apr 30, Jun 25, Oct 8, Dec 31, 2023: Mar 11, Mar 25, Apr 8, Apr 22, May 6, May 20, Jun 3, Jun 17, Sep 30, Nov 11, Nov 25, Dec 9, Dec 23, More...
American Empress Cruises8 Night - Wine Cruise from Spokane (Clarkston) to Portland (Vancouver, WA)
Starting in Spokane, WA; with stops in Clarkston, WA; Richland, WA; The Dalles, OR; Stevenson, WA; Astoria, OR; Vancouver, WA
2021 Sails: Oct 31, Nov 14, 2022: Oct 30, Nov 13, More...


United States River Cruise Departures

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