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Pensacola River Cruise Departures

River Cruises that depart from North America: United States: Florida: Pensacola

River Cruises that visit Pensacola

See all Cruises that depart from Pensacola

US South Coast Cruises

Click on a cruise ship itinerary sailing from Pensacola (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just Pensacola), please visit: Cruise Search or try our Virtual Cruise Advisor™.

River cruises by river name


American Cruise Lines, American Symphony
American Symphony Cruises7 Night - Gulf Coast Cruise
Starting in Pensacola, FL, Day of Cruising, Mobile, Al, Biloxi, MS, Ocean Springs, MS, Gulfport / Ship Island, MS, New Orleans, La
2026 Sails: Mar 7, Mar 19, More...
American Cruise Lines, American Melody
American Melody Cruises7 Night - Gulf Coast Cruise
Starting in Pensacola, FL, Day of Cruising, Mobile, Al, Biloxi, MS, Ocean Springs, MS, Gulfport / Ship Island, MS, New Orleans, La
2026 Sails: Dec 28, 2028: Mar 9, Apr 2, Dec 27, More...
American Cruise Lines, American Serenade
American Serenade Cruises7 Night - Gulf Coast Cruise
Starting in Pensacola, FL, Day of Cruising, Mobile, Al, Biloxi, MS, Ocean Springs, MS, Gulfport / Ship Island, MS, New Orleans, La
2028 Sails: May 20, More...

Pensacola River Cruise Departures