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United States Cruise Departures

Cruises that depart from North America: United States

Cruises that visit United States

See all River Cruises that depart from United States

Click on a cruise ship itinerary sailing from United States (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just United States), please visit: Cruise Search or try our Virtual Cruise Advisor™.

Related areas: Alabama : Alaska : California : Florida : Hawaii : Illinois : Kentucky : Louisiana : Maine : Maryland : Massachusetts : Minnesota : Missouri : New Jersey : New York : Oklahoma : Oregon : Pennsylvania : Rhode Island : South Carolina : Tennessee : Texas : Virginia : Washington : Washington DC : Wisconsin : Wyoming

Departing from
United States
Cruise Specials

Royal Caribbean, Freedom of the Seas
Freedom of the Seas9 Night - Southern Caribbean Cruise
Starting in Miami, Florida, Oranjestad, Aruba, Willemstad AN, Curacao, Cabo Rojo, Dominican Republic, Nassau, Bahamas, Miami, Florida
2026 Sails: Sep 24, 2027: Nov 18, More...
Royal Caribbean, Ovation Of The Seas
Ovation Of The Seas4 Night - Catalina & Ensenada Cruise
Starting in Los Angeles, California, Catalina Island, California, Ensenada, Mexico, Los Angeles, California
2026 Sails: Sep 24, More...
Viking Ocean, Viking Mars
Viking Mars12 Night - Eastern Seaboard Explorer
Starting in New York City (Brooklyn), New York, Boston, Massachusetts, Sail the Nova Scotia Coast, Halifax, Nova Scotia, Sail the Gulf of St Lawrence, Gaspe, Quebec, Sail the Gulf of St Lawrence, Saguenay, Quebec, Quebec City, Quebec, Montreal, Quebec
2026 Sails: Sep 24, More...
American Cruise Lines, American Heritage
American Heritage8 Night - Lower Mississippi River Cruise
Starting in New Orleans, La, Cruising the Lower Mississippi River, Oak Alley, LA, St Francisville, LA, Natchez, MS, Vicksburg, MS, Cleveland, MS, Memphis, TN
2026 Sails: Sep 25, Oct 18, 2028: May 30, More...
American Cruise Lines, American Ranger
American Ranger8 Night - Hudson River Fall Foliage Cruise
Starting in Albany NY, Cruising the Hudson River, Catskill, NY, Kingston, NY / Hyde Park, NY, Day of Cruising, West Point, NY, Sleepy Hollow, NY, New York, NY
2026 Sails: Sep 25, Oct 9, Oct 23, More...
American Cruise Lines, American Serenade
American Serenade15 Night - Grand Heartland Cruise
Starting in St Paul, MN, Cruising the Mississippi River, La Crosse, WI, Dubuque, IA, Davenport, IA, Day of Cruising, Hannibal, MO, Day of River Cruising, St Louis, MO, Memphis, TN, Tunica, MS, Day of Cruising, Vicksburg, MS, Natchez, MS, Baton Rouge, LA, New Orleans, La
2026 Sails: Sep 25, 2027: Sep 24, 2028: Aug 25, More...
Carnival Cruise Lines, Carnival Firenze
Carnival Firenze3 Night - Baja Mexico
Starting in Long Beach (Los Angeles), Ca, Ensenada, Mexico, Long Beach (Los Angeles), Ca
2026 Sails: Sep 25, Oct 2, Oct 9, Nov 20, Nov 27, Dec 4, Dec 18, Dec 21, Dec 28, More...
Crystal Cruises, Crystal Symphony
Crystal Symphony7 Night - North America & Canada
Starting in New York, Halifax, Sydney NS, Nova Scotia, Charlottetown, Prince Edward Island, Iles-de-la-Madeleine, Quebec, Montreal
2026 Sails: Sep 25, More...
Disney Cruise Line, Disney Magic
Disney Magic3 Night - Halloween On the High Seas Baja Cruise from San Diego
Starting in San Diego, Ensenada, San Diego
2026 Sails: Sep 25, Oct 9, More...
Princess Cruises, Grand Princess
Grand Princess10 Night - Baja Peninsula & Sea of Cortez
Starting in Los Angeles, California, Cabo San Lucas, Mexico, La Paz, Mexico, Guaymas, Mexico, Puerto Vallarta, Mexico, Los Angeles, California
2026 Sails: Sep 25, More...

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United States Cruise Departures