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United States Cruise Departures

Cruises that depart from North America: United States

Cruises that visit United States

See all River Cruises that depart from United States

Click on a cruise ship itinerary sailing from United States (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just United States), please visit: Cruise Search or try our Virtual Cruise Advisor™.

Related areas: Alabama : Alaska : California : Florida : Hawaii : Illinois : Kentucky : Louisiana : Maine : Maryland : Massachusetts : Minnesota : Missouri : New Jersey : New York : Oregon : Pennsylvania : Rhode Island : South Carolina : Tennessee : Texas : Virginia : Washington : Washington DC : Wisconsin : Wyoming

Departing from
United States
Cruise Specials

Holland America, Zuiderdam
Zuiderdam27 Night - Historic Sea of Cortez & Panama Canal
Starting in San Diego, California, Cabo San Lucas, Mexico, Pichilingue (La Paz), Mexico, Loreto, Mexico, Guaymas, Mexico, Topolobampo, Mexico, Mazatlan, Mexico, Puerto Vallarta, Mexico, Ensenada, Mexico, San Diego, California, Puerto Vallarta, Mexico, Huatulco, Mexico, Puerto Chiapas, Mexico, Puerto Quetzal, Guatemala, Fuerte Amador, Panama, Enter Panama Canal Balboa, Cruising Panama Canal, Exit Panama Canal Cristobal, Cartagena CO, Half Moon Cay, Bahamas, Miami, Florida
2026 Sails: Feb 15, More...
Holland America, Zuiderdam
Zuiderdam12 Night - Historical Baja Peninsula
Starting in San Diego, California, Cabo San Lucas, Mexico, Pichilingue (La Paz), Mexico, Loreto, Mexico, Guaymas, Mexico, Topolobampo, Mexico, Mazatlan, Mexico, Puerto Vallarta, Mexico, Ensenada, Mexico, San Diego, California
2026 Sails: Feb 15, More...
MSC Cruises, MSC Seashore
MSC Seashore4 Night - Caribbean Roundtrip from Orlando (Port Canaveral)
Starting in Port Canaveral (Orlando), Nassau, Bahamas, Ocean Cay Msc Marine Reserve, Bahamas, Port Canaveral (Orlando)
2026 Sails: Feb 15, Mar 1, Mar 15, Apr 26, Nov 1, More...
Norwegian Cruise Line, Norwegian Dawn
Norwegian Dawn10 Night - Southern Caribbean - Tampa
Starting in Tampa, Fl, Cabo Rojo, Dominican Republic, Kralendijk, Netherland Antilles, Willemstad AN, Netherlands Antilles, Falmouth, Jamaica, George Town, Cayman Islands, Tampa, Fl
2026 Sails: Feb 15, More...
Norwegian Cruise Line, Norwegian Escape
Norwegian Escape7 Night - Western Caribbean - New Orleans
Starting in New Orleans, La, Cozumel, Mexico, Roatan Bay Islands, Honduras, Harvest Caye, Belize, Costa Maya, Mexico, New Orleans, La
2026 Sails: Feb 15, More...
Princess Cruises, Enchanted Princess
Enchanted Princess20 Night - Caribbean Explorer
Starting in Fort Lauderdale, Florida, Princess Cays, Bahamas, St Thomas, US Virgin Islands, St Maarten, Antigua, St Kitts, Tortola, British Virgin Islands, Fort Lauderdale, Florida, Princess Cays, Bahamas, St Thomas, US Virgin Islands, Dominica, Barbados, Martinique, Antigua, Fort Lauderdale, Florida
2026 Sails: Feb 15, More...
Princess Cruises, Enchanted Princess
Enchanted Princess10 Night - Eastern Caribbean with Tortola
Starting in Fort Lauderdale, Florida, Princess Cays, Bahamas, St Thomas, US Virgin Islands, St Maarten, Antigua, St Kitts, Tortola, British Virgin Islands, Fort Lauderdale, Florida
2026 Sails: Feb 15, More...
Royal Caribbean, Oasis of the Seas
Oasis of the Seas6 Night - Western Caribbean Cruise
Starting in Fort Lauderdale, Florida, Nassau, Bahamas, San Juan, Puerto Rico, Puerto Plata, Dominican Republic, Fort Lauderdale, Florida
2026 Sails: Feb 15, More...
Royal Caribbean, Odyssey of the Seas
Odyssey of the Seas7 Night - Perfect Day Bahamas Cruise
Starting in Cape Liberty, Nj (Ny Metro), Orlando (Port Canaveral), Fl, Perfect Day Cococay, Bahamas, Nassau, Bahamas, Cape Liberty, Nj (Ny Metro)
2026 Sails: Feb 15, Feb 22, More...
Royal Caribbean, Rhapsody of the Seas
Rhapsody of the Seas6 Night - Western Caribbean Cruise
Starting in Tampa, Florida, Puerto Costa Maya, Mexico, Roatan, Honduras, Cozumel, Mexico, Tampa, Florida
2026 Sails: Feb 15, More...

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United States Cruise Departures