United States Cruise Departures

Cruises that depart from North America: United States

Cruises that visit United States

See all River Cruises that depart from United States

Click on a cruise ship itinerary sailing from United States (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just United States), please visit: Cruise Search or try our Virtual Cruise Advisor™.

Departing from
United States
Cruise Specials

Lindblad Expeditions, National Geographic Quest

13 Night - Treasures of the Inside Passage
Starting in Seattle, Washington / Embark Ship, San Juan Islands, Washington, Victoria CA, Canada, Gulf Islands, Alert Bay and Johnstone Strait, British Columbia, Inside Passage of British Columbia, Misty Fjords, Alaska, Petersburg, Tracy Arm / Fords Terror Wilderness, Glacier Bay National Park, Inian Islands / Icy Strait, Baranof or Chichagof Island, Sitka / Disembark Ship
2026 Sails: Apr 26, More...

MSC Cruises, MSC Seascape

Deal link -> Special

7 Night - Caribbean and Antilles
Starting in Galveston, Texas, Costa Maya, Mexico, Isla De Roatan, Honduras, Cozumel, Mexico, Galveston, Texas
2026 Sails: Apr 26, May 3, May 10, May 17, May 24, May 31, Jun 7, Jun 14, Jun 21, Jun 28, Jul 5, Jul 12, Jul 26, Aug 2, Aug 9, Aug 16, Aug 30, Sep 6, Sep 13, Sep 20, Sep 27, Oct 4, Oct 18, Oct 25, More...

MSC Cruises, MSC Seashore

4 Night - Caribbean and Antilles
Starting in Port Canaveral (Orlando), Florida, Nassau, Bahamas, Ocean Cay Msc Marine Reserve, Bahamas, Port Canaveral (Orlando), Florida
2026 Sails: Apr 26, Nov 1, More...

Norwegian Cruise Line, Norwegian Breakaway

7 Night - Bermuda - Boston
Starting in Boston, Ma, Royal Naval Dockyard, Bermuda, Boston, Ma
2026 Sails: Apr 26, More...

Princess Cruises, Emerald Princess

7 Night - Mexican Riviera
Starting in Los Angeles, California, Cabo San Lucas, Mexico, Mazatlan, Mexico, Puerto Vallarta, Mexico, Los Angeles, California
2026 Sails: Apr 26, More...

Royal Caribbean, Brilliance of the Seas

15 Night - Spain & Bermuda Transatlantic
Starting in Fort Lauderdale, Florida, Perfect Day Cococay, Bahamas, Royal Naval Dockyard, Bermuda, Ponta Delgada, Azores, Malaga, Spain, Alicante, Spain, Valencia, Spain, Barcelona, Spain
2026 Sails: Apr 26, More...

Royal Caribbean, Symphony of the Seas

4 Night - Western Caribbean Cruise
Starting in Miami, Florida, Cozumel, Mexico, Miami, Florida
2026 Sails: Apr 26, More...

Seabourn, Seabourn Quest

14 Night - Atlantic Crossing
Starting in Miami, Florida, Ponta Delgada, Sao Miguel, Azores, Portugal, Tangier, Morocco, Lisbon, Portugal
2026 Sails: Apr 26, More...

Virgin Voyages, Brilliant Lady

7 Night - Mexican Riviera Cruise
Starting in Los Angeles, California, Cabo San Lucas, Mexico, Mazatlan, Mexico, Puerto Vallarta, Mexico, Los Angeles, California
2026 Sails: Apr 26, Sep 19, Sep 26, 2027: Apr 11, Apr 18, Apr 25, Sep 18, Sep 25, Oct 2, Oct 16, Oct 23, More...

Virgin Voyages, Scarlet Lady

14 Night - Transatlantic to Spain & Morocco
Starting in Miami, Florida, Las Palmas De Gran Canaria, Spain, Casablanca, Morocco, Alicante, Spain, Barcelona, Spain
2026 Sails: Apr 26, More...

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United States Cruise Departures