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Panama Cruises

Cruises that visit Central America: Panama

Cruises that depart from Panama

See all River Cruises that visit Panama

Click on a cruise ship itinerary that visits Panama (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just Panama), please visit: Cruise Search or try our Virtual Cruise Advisor™.

Related areas: Azuero Peninsula : Balboa : Barro Colorado Island : Bocas del Toro : Cebaco Island : Chiriqui Lagoon : Coiba Island : Colon : Cristobal : Darien : Flamenco Island : Fort San Lorenzo : Fuerte Amador : Gatun : Gulf of Panama : Guna Yala : Holandes Cays : Isla del Rey : Isla Iguana : Lemon Cay : Mogo Mogo Island : Pacheca Island : Panama Canal : Panama City : Parida Island : Pearl Islands : Playa Muerto : Portobelo : Punta Patino : San Blas Islands : San Jose Island

Panama
Cruise Specials

Holland America, Oosterdam
Oosterdam16 Night - Inca & Panama Canal Discovery : Lima Overnight
Starting in Fort Lauderdale, Florida, Georgetown, Cayman Islands, Enter Panama Canal Cristobal, Cruising Panama Canal, Exit Panama Canal Balboa, Fuerte Amador, Panama, Crossing the Equator, Manta, Ecuador, Salaverry (Trujillo), Peru, Callao (Lima), Peru, General San Martin (Pisco), Peru, Coquimbo (La Serena), Chile, Valparaiso (Santiago), Chile
2026 Sails: Nov 18, More...
Norwegian Cruise Line, Norwegian Sun
Norwegian Sun11 Night - Panama Canal - Miami
Starting in Miami, Fl, Great Stirrup Cay, Bahamas, Cartagena CO, Panama Canal Gatun Lake, Panama, Colon, Panama, Puerto Limon, Costa Rica, Falmouth, Jamaica, George Town, Cayman Islands, Miami, Fl
2026 Sails: Nov 18, Nov 29, More...
PONANT, Le Bellot
Le Bellot10 Night - Secrets of Central America
Starting in Colon, Fort San Lorenzo (Colon), San Blas Islands, Crossing the Panama Canal, Pearls Islands, Pacheca Island, Playa Muerto, Darien National Park, Coiba Island, Rio Esquinas, Drake Bay, Curu Wildlife Refuge, Puntarenas
2026 Sails: Nov 21, 2027: Jan 14, More...
MSC Cruises, MSC Poesia
MSC Poesia21 Night - Caribbean and Antilles
Starting in Miami, Florida, Ocho Rios, Jamaica, Cartagena CO, Colon, Panama, Puerto Limon, Costa Rica, Isla De Roatan, Honduras, Belize City, Belize, Miami, Florida, Willemstad AN, Curacao, Oranjestad, Aruba, Cabo Rojo, Dominican Republic, Ocho Rios, Jamaica, George Town, Cayman Islands, Miami, Florida
2026 Sails: Nov 22, More...
Celebrity Cruises, Celebrity Ascent
Celebrity Ascent11 Night - Panama Canal & Southern Caribbean
Starting in Fort Lauderdale, Florida, Cartagena CO, Panama Canal (Cruising), Colon, Panama, Oranjestad, Aruba, Willemstad AN, Curacao, Kralendijk, Bonaire, Fort Lauderdale, Florida
2026 Sails: Nov 23, 2027: Mar 8, More...
Crystal Cruises, Crystal Serenity
Crystal Serenity19 Night - The Americas & Caribbean
Starting in Fort Lauderdale, Nassau (Paradise Island), Samana, San Juan, Jost Van Dyke, British Virgin Islands, Oranjestad, Aruba, Cartagena CO, Willemstad AN, Kralendijk, Oranjestad, Aruba, Santa Marta, Panama Canal Transit, Fuerte Amador (Panama City), Puntarenas
2026 Sails: Nov 23, More...
Crystal Cruises, Crystal Serenity
Crystal Serenity28 Night - The Americas & Caribbean
Starting in Fort Lauderdale, Nassau (Paradise Island), Samana, San Juan, Jost Van Dyke, British Virgin Islands, Oranjestad, Aruba, Cartagena CO, Willemstad AN, Kralendijk, Oranjestad, Aruba, Santa Marta, Panama Canal Transit, Fuerte Amador (Panama City), Puntarenas, Playa Flamingo, Acajutla, Zihuatanejo, Manzanillo, Puerto Vallarta, San Diego
2026 Sails: Nov 23, More...
Princess Cruises, Caribbean Princess
Caribbean Princess12 Night - Panama Canal with Costa Rica & Caribbean
Starting in Fort Lauderdale, Florida, Aruba, Cartagena CO, Panama Canal Partial Transit New Locks, Colon, Panama, Limon, Costa Rica, Celebration Key, Bahamas, Fort Lauderdale, Florida
2026 Sails: Nov 23, 2027: Jan 22, More...
Costa Cruise Lines, Costa Deliziosa
Costa Deliziosa66 Night - Round World from Civitavecchia (Rome)
Starting in Civitavecchia (Rome), Savona, Marseille, Barcelona, Lisbon, Ponta Delgada (Azores), Praia da Vitoria (Azores), New York, Port Everglades, Half Moon Cay, Panama City, Puntarenas, Puerto Quetzal, Puerto Vallarta, Cabo San Lucas, San Diego, Los Angeles, San Francisco, Honolulu, Hilo, Papeete (Tahiti), Suva, Lifou (Loyalty Islands), Noumea, Sydney AU
2026 Sails: Nov 24, More...
Costa Cruise Lines, Costa Deliziosa
Costa Deliziosa40 Night - Round World from Civitavecchia
Starting in Civitavecchia (Rome), Savona, Marseille, Barcelona, Lisbon, Ponta Delgada (Azores), Praia da Vitoria (Azores), New York, Port Everglades, Half Moon Cay, Panama City, Puntarenas, Puerto Quetzal, Puerto Vallarta, Cabo San Lucas, San Diego, Los Angeles, San Francisco
2026 Sails: Nov 24, More...

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Panama Cruises