Panama Cruises

Cruises that visit Central America: Panama

Cruises that depart from Panama

Click on a cruise ship itinerary that visits Panama (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just Panama), please visit: Cruise Search or try our Virtual Cruise Advisor™.

Viking Ocean, Viking Polaris

19 Night - Panama Canal & the Americas
Starting in Santiago (Valparaiso), Sail the Pacific Ocean, Iquique, Sail the Pacific Ocean, Lima (Callao), Sail the Pacific Ocean, Panama City (Fuerte Amador), Scenic Sailing Panama Canal, Sail the Caribbean Sea, Port Antonio, Man of War Bay (Great Inagua), San Salvador Island, Sail the Atlantic Ocean, New York City, New York
2026 Sails: Mar 17, More...

Virgin Voyages, Brilliant Lady

16 Night - Panama Canal & Pacific Wonders
Starting in Miami, Florida, Cartagena CO, Colon, Panama, Panama Canal (Cruising), Panama, Puntarenas, Costa Rica, Puerto Quetzal, Guatemala, Cabo San Lucas, Mexico, Los Angeles, California
2026 Sails: Mar 21, More...

Holland America, Oosterdam

17 Night - Inca & Panama Canal Discovery
Starting in San Antonio CL (Santiago), Chile, Coquimbo (La Serena), Chile, General San Martin (Pisco), Peru, Callao (Lima), Peru, Salaverry (Trujillo), Peru, Manta, Ecuador, Fuerte Amador, Panama, Enter Panama Canal Balboa, Cruising Panama Canal, Exit Panama Canal Cristobal, Georgetown, Cayman Islands, Fort Lauderdale, Florida
2026 Sails: Mar 22, More...

MSC Cruises, MSC Divina

18 Night - Caribbean and Antilles
Starting in Miami, Florida, Ocean Cay Msc Marine Reserve, Bahamas, Cozumel, Mexico, George Town, Cayman Islands, Ocho Rios, Jamaica, Miami, Florida, Ocho Rios, Jamaica, Oranjestad, Aruba, Cartagena CO, Colon, Panama, Isla De Roatan, Honduras, Ocean Cay Msc Marine Reserve, Bahamas, Miami, Florida
2026 Sails: Mar 22, More...

Holland America, Volendam

54 Night - Grand World Voyage
Starting in Singapore, Phu My, Vietnam, Da Nang (Hue), Vietnam, Halong Bay, Vietnam, Hong Kong, China, Kaohsiung, Taiwan, Keelung (Taipei), Taiwan, Naha, Japan, Amami (Naze), Amami Oshima, Japan, Nagasaki, Japan, Shimizu, Japan, Yokohama (Tokyo), Japan, Hakodate, Japan, Cross International Dateline, Kodiak, Alaska, Sitka, Alaska, Ketchikan, Alaska, Seattle, Washington, San Diego, California, Manzanillo, Mexico, Puerto Chiapas, Mexico, Acajutla, El Salvador, Fuerte Amador, Panama, Enter Panama Canal Balboa, Cruising Panama Canal, Exit Panama Canal Cristobal, Cartagena CO, Fort Lauderdale, Florida
2026 Sails: Mar 24, More...

Oceania Cruises, Oceania Insignia

20 Night - Panama Canal Connoisseur
Starting in Tampa, Cozumel, Mexico, Costa Maya, Mexico, Belize City, Roatan, Puerto Limon, Colon, Panama Canal Daylight Transit, Panama City, Panama Canal Daylight Transit, Cartagena CO, Willemstad AN, Oranjestad, Montego Bay, George Town, Miami
2026 Sails: Mar 25, More...

Oceania Cruises, Oceania Insignia

10 Night - Palms & Panama Canal
Starting in Tampa, Cozumel, Mexico, Costa Maya, Mexico, Belize City, Roatan, Puerto Limon, Colon, Panama Canal Daylight Transit, Panama City
2026 Sails: Mar 25, More...

PONANT, Le Champlain

12 Night - Panama, Colombia & Caribbean Islands
Starting in Colon, Portobelo, San Blas Islands, Cartagena, Santa Marta, Bonaire, Mayreau Island, Union Island, Pigeon Island Beach, Soufriere, Les Saintes, Fort-de-France
2026 Sails: Mar 25, More...

Scenic Luxury, Scenic Eclipse II

19 Night - Treasures of French Polynesia & the Marquesas Islands
Starting in Papeete, Opunohu Bay, Moorea, Rangiroa, Tuamotus, Taiohae, Nuku Hiva Island, French Polynesia, Atuona, Hiva Oa Island, French Polynesia, Cocos Island, Costa Rica, Panama City, Panama
2026 Sails: Mar 25, More...

Viking Ocean, Viking Octantis

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