Panama City Cruises
Cruises that visit Central America: Panama: Panama City
Cruises that depart from Panama City
See all River Cruises that visit Panama City
40 Night - Seattle to Miami
Starting in Seattle, WA, Ketchikan, AK, Juneau, AK, Endicott Arm, AK, (Scenic Cruising), Victoria CA, Canada, Seattle, WA, Los Angeles, CA, Cabo San Lucas, Mexico, Puerto Quetzal, Guatemala, Fuerte Amador (tours to Panama City), Panama, Transit the Panama Canal, Panama (Full Transit), Willemstad AN, Curacao, Oranjestad, Aruba, Miami, FL, San Juan, Puerto Rico, St Johns AG, Antigua, Castries, St Lucia, Bridgetown, Barbados, Philipsburg, St Maarten, Road Town, Tortola, Miami, FL
2026 Sails: Sep 17, More...
16 Night - Panama Canal - Ocean to Ocean
Starting in Los Angeles, California, Puerto Vallarta, Mexico, Huatulco, Mexico, Puerto Chiapas, Mexico, Puntarenas, Costa Rica, Fuerte Amador, Panama (for Panama City), Panama Canal Full Transit Historic Locks, Aruba, Fort Lauderdale, Florida
2026 Sails: Sep 20, More...
22 Night - Panama Canal & Pacific Coast
Starting in Vancouver, Canada, San Francisco, California, San Diego, California, Los Angeles, California, Puerto Vallarta, Mexico, Huatulco, Mexico, Puerto Chiapas, Mexico, Puntarenas, Costa Rica, Fuerte Amador, Panama (for Panama City), Panama Canal Full Transit Historic Locks, Aruba, Fort Lauderdale, Florida
2026 Sails: Sep 23, More...21 Night - Seattle to Miami
Starting in Seattle, WA, Los Angeles, CA, Cabo San Lucas, Mexico, Puerto Quetzal, Guatemala, Fuerte Amador (tours to Panama City), Panama, Transit the Panama Canal, Panama (Full Transit), Willemstad AN, Curacao, Oranjestad, Aruba, Miami, FL
2026 Sails: Sep 24, More...
23 Night - Panama Canal & Pacific Coast
Starting in Vancouver, Canada, Victoria CA, San Francisco, California, Los Angeles, California, Cabo San Lucas, Mexico, Mazatlan, Mexico, Fuerte Amador, Panama (for Panama City), Panama Canal Full Transit New Locks, Aruba, Fort Lauderdale, Florida
2026 Sails: Sep 27, More...16 Night - Panama Canal - Ocean to Ocean
Starting in Los Angeles, California, Puerto Vallarta, Mexico, Huatulco, Mexico, Puerto Chiapas, Mexico, Puntarenas, Costa Rica, Fuerte Amador, Panama (for Panama City), Panama Canal Full Transit Historic Locks, Aruba, Fort Lauderdale, Florida
2026 Sails: Sep 29, More...
13 Night - Magic of Colombia with in Medellin Pre Cruise and in Panama City Post Cruise
Starting in Medellin, Barranquilla, Medellin, Sitionuevo, Magangue, Mompox, Santa Barbara de Pinto, Calamar, Mahates, Cartagena CO, Colombia, Panama City
2026 Sails: Sep 30, Oct 14, Oct 28, Nov 11, Nov 25, Dec 9, More...10 Night - Magic of Colombia with Panama Post Cruise
Starting in Barranquilla, Sitionuevo, Magangue, Mompox, Santa Barbara de Pinto, Calamar, Mahates, Cartagena CO, Colombia, Panama City
2026 Sails: Oct 3, Oct 17, Oct 31, Nov 14, Nov 28, Dec 12, More...16 Night - Panama Canal - Ocean to Ocean
Starting in Los Angeles, California, Cabo San Lucas, Mexico, Mazatlan, Mexico, Fuerte Amador, Panama (for Panama City), Panama Canal Full Transit New Locks, Aruba, Fort Lauderdale, Florida
2026 Sails: Oct 4, More...15 Night - Wonders of Colombia with in Medellin, in Cartagena Pre Cruise and in Panama City Post Cruise
Starting in Medellin, Cartagena CO, Colombia, Mahates, Calamar, Magangue, Mompox, Santa Barbara de Pinto, Sitionuevo, Barranquilla, Panama City
2026 Sails: Oct 5, Oct 19, Nov 16, Nov 30, 2027: May 17, More...
Cruises that visit Central America: Panama: Panama City
Cruises that depart from Panama City
See all River Cruises that visit Panama City
Click on a cruise ship itinerary that visits Panama City (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just Panama City), please visit: Cruise Search or try our Virtual Cruise Advisor™.
40 Night - Seattle to MiamiStarting in Seattle, WA, Ketchikan, AK, Juneau, AK, Endicott Arm, AK, (Scenic Cruising), Victoria CA, Canada, Seattle, WA, Los Angeles, CA, Cabo San Lucas, Mexico, Puerto Quetzal, Guatemala, Fuerte Amador (tours to Panama City), Panama, Transit the Panama Canal, Panama (Full Transit), Willemstad AN, Curacao, Oranjestad, Aruba, Miami, FL, San Juan, Puerto Rico, St Johns AG, Antigua, Castries, St Lucia, Bridgetown, Barbados, Philipsburg, St Maarten, Road Town, Tortola, Miami, FL
2026 Sails: Sep 17, More...
16 Night - Panama Canal - Ocean to OceanStarting in Los Angeles, California, Puerto Vallarta, Mexico, Huatulco, Mexico, Puerto Chiapas, Mexico, Puntarenas, Costa Rica, Fuerte Amador, Panama (for Panama City), Panama Canal Full Transit Historic Locks, Aruba, Fort Lauderdale, Florida
2026 Sails: Sep 20, More...
22 Night - Panama Canal & Pacific CoastStarting in Vancouver, Canada, San Francisco, California, San Diego, California, Los Angeles, California, Puerto Vallarta, Mexico, Huatulco, Mexico, Puerto Chiapas, Mexico, Puntarenas, Costa Rica, Fuerte Amador, Panama (for Panama City), Panama Canal Full Transit Historic Locks, Aruba, Fort Lauderdale, Florida
2026 Sails: Sep 23, More...
21 Night - Seattle to MiamiStarting in Seattle, WA, Los Angeles, CA, Cabo San Lucas, Mexico, Puerto Quetzal, Guatemala, Fuerte Amador (tours to Panama City), Panama, Transit the Panama Canal, Panama (Full Transit), Willemstad AN, Curacao, Oranjestad, Aruba, Miami, FL
2026 Sails: Sep 24, More...
23 Night - Panama Canal & Pacific CoastStarting in Vancouver, Canada, Victoria CA, San Francisco, California, Los Angeles, California, Cabo San Lucas, Mexico, Mazatlan, Mexico, Fuerte Amador, Panama (for Panama City), Panama Canal Full Transit New Locks, Aruba, Fort Lauderdale, Florida
2026 Sails: Sep 27, More...
16 Night - Panama Canal - Ocean to OceanStarting in Los Angeles, California, Puerto Vallarta, Mexico, Huatulco, Mexico, Puerto Chiapas, Mexico, Puntarenas, Costa Rica, Fuerte Amador, Panama (for Panama City), Panama Canal Full Transit Historic Locks, Aruba, Fort Lauderdale, Florida
2026 Sails: Sep 29, More...
13 Night - Magic of Colombia with in Medellin Pre Cruise and in Panama City Post CruiseStarting in Medellin, Barranquilla, Medellin, Sitionuevo, Magangue, Mompox, Santa Barbara de Pinto, Calamar, Mahates, Cartagena CO, Colombia, Panama City
2026 Sails: Sep 30, Oct 14, Oct 28, Nov 11, Nov 25, Dec 9, More...
10 Night - Magic of Colombia with Panama Post CruiseStarting in Barranquilla, Sitionuevo, Magangue, Mompox, Santa Barbara de Pinto, Calamar, Mahates, Cartagena CO, Colombia, Panama City
2026 Sails: Oct 3, Oct 17, Oct 31, Nov 14, Nov 28, Dec 12, More...
16 Night - Panama Canal - Ocean to OceanStarting in Los Angeles, California, Cabo San Lucas, Mexico, Mazatlan, Mexico, Fuerte Amador, Panama (for Panama City), Panama Canal Full Transit New Locks, Aruba, Fort Lauderdale, Florida
2026 Sails: Oct 4, More...
15 Night - Wonders of Colombia with in Medellin, in Cartagena Pre Cruise and in Panama City Post CruiseStarting in Medellin, Cartagena CO, Colombia, Mahates, Calamar, Magangue, Mompox, Santa Barbara de Pinto, Sitionuevo, Barranquilla, Panama City
2026 Sails: Oct 5, Oct 19, Nov 16, Nov 30, 2027: May 17, More...
