Panama City Cruises
Cruises that visit Central America: Panama: Panama City
Cruises that depart from Panama City
See all River Cruises that visit Panama City
13 Night - Magic of Colombia with in Medellin Pre Cruise and in Panama City Post Cruise
Starting in Medellin, Barranquilla, Medellin, San Felipe, Magangue, Mompox, Calamar, Manzini, Cartagena CO, Colombia, Panama City
2026 Sails: Apr 29, May 27, Jun 10, Jun 24, Jul 8, Aug 19, Sep 2, Sep 30, Oct 14, Oct 28, Nov 11, Nov 25, Dec 9, Dec 23, More...
10 Night - Magic of Colombia with Panama Post Cruise
Starting in Barranquilla, San Felipe, Magangue, Mompox, Calamar, Manzini, Cartagena CO, Colombia, Panama City
2026 Sails: Apr 29, May 13, May 27, Jun 10, Jul 22, Aug 5, Aug 19, Sep 2, Sep 16, Oct 28, Nov 11, Nov 25, Dec 9, More...15 Night - Wonders of Colombia with in Medellin, in Cartagena Pre Cruise and in Panama City Post Cruise
Starting in Medellin, Cartagena CO, Colombia, Manzini, Calamar, Magangue, Mompox, San Felipe, Barranquilla, Panama City
2026 Sails: May 1, May 15, May 29, Jun 12, Aug 7, Aug 21, Sep 4, Oct 30, Nov 13, Nov 27, Dec 11, More...10 Night - Magic of Colombia with Panama Post Cruise
Starting in Barranquilla, San Felipe, Magangue, Mompox, Calamar, Manzini, Cartagena CO, Colombia, Panama City
2026 Sails: May 2, May 30, Jun 13, Jun 27, Jul 11, Aug 22, Sep 5, Oct 3, Oct 17, Oct 31, Nov 14, Nov 28, Dec 12, Dec 26, More...15 Night - Wonders of Colombia with in Medellin, in Cartagena Pre Cruise and in Panama City Post Cruise
Starting in Medellin, Cartagena CO, Colombia, Manzini, Calamar, Magangue, Mompox, San Felipe, Barranquilla, Panama City
2026 Sails: May 4, Jun 1, Jun 15, Jun 29, Jul 13, Aug 24, Sep 7, Oct 5, Oct 19, Nov 2, Nov 16, Nov 30, 2027: May 17, More...10 Night - Wonders of Colombia with in Panama City Post Cruise
Starting in Cartagena CO, Colombia, Manzini, Calamar, Magangue, Mompox, San Felipe, Barranquilla, Panama City
2026 Sails: May 6, May 20, Jun 3, Jun 17, Aug 12, Aug 26, Sep 9, Nov 4, Nov 18, Dec 2, Dec 16, More...10 Night - Wonders of Colombia with in Panama City Post Cruise
Starting in Cartagena CO, Colombia, Manzini, Calamar, Magangue, Mompox, San Felipe, Barranquilla, Panama City
2026 Sails: May 9, Jun 6, Jun 20, Jul 4, Jul 18, Aug 29, Sep 12, Oct 10, Oct 24, Nov 7, Nov 21, Dec 5, 2027: May 22, More...13 Night - Magic of Colombia with in Medellin Pre Cruise and in Panama City Post Cruise
Starting in Medellin, Barranquilla, Medellin, San Felipe, Magangue, Mompox, Calamar, Manzini, Cartagena CO, Colombia, Panama City
2026 Sails: May 10, May 24, Jun 7, Jul 19, Aug 2, Aug 16, Aug 30, Sep 13, Oct 25, Nov 8, Nov 22, Dec 6, More...
39 Night - The Americas & Caribbean
Starting in Vancouver, Victoria CA, Canada, Astoria, Eureka, California, San Francisco, San Diego, Ensenada, Cabo San Lucas (Baja California Sur), Puerto Vallarta, Acajutla, Playa Flamingo, Puntarenas, Manta, Guayaquil, Fuerte Amador (Panama City), Panama Canal Transit, Cartagena CO, Santo Domingo, Punta Cana, San Juan, Marigot, St Martin, Roseau, Bridgetown, Castries, St Lucia, St Johns, Jost Van Dyke, British Virgin Islands, Samana, Grand Turk, New York
2026 Sails: Aug 17, More...32 Night - The Americas & Caribbean
Starting in San Diego, Ensenada, Cabo San Lucas (Baja California Sur), Puerto Vallarta, Acajutla, Playa Flamingo, Puntarenas, Manta, Guayaquil, Fuerte Amador (Panama City), Panama Canal Transit, Cartagena CO, Santo Domingo, Punta Cana, San Juan, Marigot, St Martin, Roseau, Bridgetown, Castries, St Lucia, St Johns, Jost Van Dyke, British Virgin Islands, Samana, Grand Turk, New York
2026 Sails: Aug 24, More...
Cruises that visit Central America: Panama: Panama City
Cruises that depart from Panama City
See all River Cruises that visit Panama City
Click on a cruise ship itinerary that visits Panama City (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just Panama City), please visit: Cruise Search or try our Virtual Cruise Advisor™.
13 Night - Magic of Colombia with in Medellin Pre Cruise and in Panama City Post CruiseStarting in Medellin, Barranquilla, Medellin, San Felipe, Magangue, Mompox, Calamar, Manzini, Cartagena CO, Colombia, Panama City
2026 Sails: Apr 29, May 27, Jun 10, Jun 24, Jul 8, Aug 19, Sep 2, Sep 30, Oct 14, Oct 28, Nov 11, Nov 25, Dec 9, Dec 23, More...
10 Night - Magic of Colombia with Panama Post CruiseStarting in Barranquilla, San Felipe, Magangue, Mompox, Calamar, Manzini, Cartagena CO, Colombia, Panama City
2026 Sails: Apr 29, May 13, May 27, Jun 10, Jul 22, Aug 5, Aug 19, Sep 2, Sep 16, Oct 28, Nov 11, Nov 25, Dec 9, More...
15 Night - Wonders of Colombia with in Medellin, in Cartagena Pre Cruise and in Panama City Post CruiseStarting in Medellin, Cartagena CO, Colombia, Manzini, Calamar, Magangue, Mompox, San Felipe, Barranquilla, Panama City
2026 Sails: May 1, May 15, May 29, Jun 12, Aug 7, Aug 21, Sep 4, Oct 30, Nov 13, Nov 27, Dec 11, More...
10 Night - Magic of Colombia with Panama Post CruiseStarting in Barranquilla, San Felipe, Magangue, Mompox, Calamar, Manzini, Cartagena CO, Colombia, Panama City
2026 Sails: May 2, May 30, Jun 13, Jun 27, Jul 11, Aug 22, Sep 5, Oct 3, Oct 17, Oct 31, Nov 14, Nov 28, Dec 12, Dec 26, More...
15 Night - Wonders of Colombia with in Medellin, in Cartagena Pre Cruise and in Panama City Post CruiseStarting in Medellin, Cartagena CO, Colombia, Manzini, Calamar, Magangue, Mompox, San Felipe, Barranquilla, Panama City
2026 Sails: May 4, Jun 1, Jun 15, Jun 29, Jul 13, Aug 24, Sep 7, Oct 5, Oct 19, Nov 2, Nov 16, Nov 30, 2027: May 17, More...
10 Night - Wonders of Colombia with in Panama City Post CruiseStarting in Cartagena CO, Colombia, Manzini, Calamar, Magangue, Mompox, San Felipe, Barranquilla, Panama City
2026 Sails: May 6, May 20, Jun 3, Jun 17, Aug 12, Aug 26, Sep 9, Nov 4, Nov 18, Dec 2, Dec 16, More...
10 Night - Wonders of Colombia with in Panama City Post CruiseStarting in Cartagena CO, Colombia, Manzini, Calamar, Magangue, Mompox, San Felipe, Barranquilla, Panama City
2026 Sails: May 9, Jun 6, Jun 20, Jul 4, Jul 18, Aug 29, Sep 12, Oct 10, Oct 24, Nov 7, Nov 21, Dec 5, 2027: May 22, More...
13 Night - Magic of Colombia with in Medellin Pre Cruise and in Panama City Post CruiseStarting in Medellin, Barranquilla, Medellin, San Felipe, Magangue, Mompox, Calamar, Manzini, Cartagena CO, Colombia, Panama City
2026 Sails: May 10, May 24, Jun 7, Jul 19, Aug 2, Aug 16, Aug 30, Sep 13, Oct 25, Nov 8, Nov 22, Dec 6, More...
39 Night - The Americas & CaribbeanStarting in Vancouver, Victoria CA, Canada, Astoria, Eureka, California, San Francisco, San Diego, Ensenada, Cabo San Lucas (Baja California Sur), Puerto Vallarta, Acajutla, Playa Flamingo, Puntarenas, Manta, Guayaquil, Fuerte Amador (Panama City), Panama Canal Transit, Cartagena CO, Santo Domingo, Punta Cana, San Juan, Marigot, St Martin, Roseau, Bridgetown, Castries, St Lucia, St Johns, Jost Van Dyke, British Virgin Islands, Samana, Grand Turk, New York
2026 Sails: Aug 17, More...
32 Night - The Americas & CaribbeanStarting in San Diego, Ensenada, Cabo San Lucas (Baja California Sur), Puerto Vallarta, Acajutla, Playa Flamingo, Puntarenas, Manta, Guayaquil, Fuerte Amador (Panama City), Panama Canal Transit, Cartagena CO, Santo Domingo, Punta Cana, San Juan, Marigot, St Martin, Roseau, Bridgetown, Castries, St Lucia, St Johns, Jost Van Dyke, British Virgin Islands, Samana, Grand Turk, New York
2026 Sails: Aug 24, More...
