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Panama City Cruises

Cruises that visit Central America: Panama: Panama City

Cruises that depart from Panama City

Click on a cruise ship itinerary that visits Panama City (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just Panama City), please visit: Cruise Search or try our Virtual Cruise Advisor™.


Safari Voyager Cruises7 Night - Unveiled Wonders - Costa Rica & Panama Cruise from San Jose to Panama City
Starting in San José, Costa Rica; with stops in Curú National Wildlife Refuge; Osa Conservation Area; Golfo Dulce, Costa Rica; Granito de Oro, Coiba National Park; Gulf of Panama | Marine Life Search; Panama City, Panama
2021 Sails: Oct 1, Dec 10, Dec 24, 2022: Oct 1, Dec 10, Dec 24, More...
MS Roald Amundsen Cruises7 Night - Hidden Highlights of the Caribbean from George Town to Panama City
Starting in George Town, Cayman Islands with stops in Isla de Providencia, Colombia; Corn Island, Nicaragua; Bocas del Toro, Panama; San Blas Island, Panama; Panama Canal, Panama; Panama City, Panama
2021 Sails: Oct 2, More...
MS Roald Amundsen Cruises11 Night - Panama, Ecuador and Peru - Incan Mysteries and Machu Picchu from Panama City to Lima
Starting in Panama City with stops in Manta, Ecuador; Puerto Bolivar (Machala), Ecuador; Guayaquil, Ecuador; Salaverry, Peru; Callao/Lima/Cusco/Sacred Valley; Sacred Valley/Machu Picchu/Sacred Valley; Sacred Valley/Cusco/Lima; Lima
2021 Sails: Oct 8, More...
MS Roald Amundsen Cruises13 Night - Panama, Ecuador and Peru - Incan Mysteries and Galapagos Islands from Panama City to Guayaquil
Starting in Panama City with stops in Manta, Ecuador; Puerto Bolivar (Machala), Ecuador; Guayaquil, Ecuador; Salaverry, Peru; Callao / Lima, Peru / Quito, Ecuador; Quito/Baltra Island/Santa Cruz Island; Santa Cruz Island/Baltra Island/Guayaquil
2021 Sails: Oct 8, More...
MS Fridtjof Nansen Cruises7 Night - Hidden Highlights of the Caribbean from George Town to Panama City
Starting in George Town, Cayman Islands with stops in Isla de Providencia, Colombia; Corn Island, Nicaragua; Bocas del Toro, Panama; San Blas Island, Panama; Panama Canal, Panama; Panama City, Panama
2021 Sails: Oct 12, More...
MS Fridtjof Nansen Cruises11 Night - Panama, Ecuador and Peru - Incan Mysteries and Machu Picchu from Panama City to Lima
Starting in Panama City with stops in Manta, Ecuador; Puerto Bolivar (Machala), Ecuador; Guayaquil, Ecuador; Salaverry, Peru; Callao/Lima/Cusco/Sacred Valley; Sacred Valley/Machu Picchu/Sacred Valley; Sacred Valley/Cusco/Lima; Lima
2021 Sails: Oct 18, More...
MS Fridtjof Nansen Cruises13 Night - Panama, Ecuador and Peru - Incan Mysteries and Galapagos Islands from Panama City to Guayaquil
Starting in Panama City with stops in Manta, Ecuador; Puerto Bolivar (Machala), Ecuador; Guayaquil, Ecuador; Salaverry, Peru; Callao / Lima, Peru / Quito, Ecuador; Quito/Baltra Island/Santa Cruz Island; Santa Cruz Island/Baltra Island/Guayaquil
2021 Sails: Oct 18, More...
Viking Star Cruises10 Night - Classic Panama Canal Passage - Ft. Lauderdale to Panama City (Fuerte Amador)
Starting in Ft. Lauderdale with stops in Key West, Scenic Cruising: Gulf of Mexico, Cozumel, Belize City, Roatan, Cruise the Caribbean Sea, Puerto Limon, Colon, Scenic Cruising: Panama Canal, Panama City (Fuerte Amador)
2021 Sails: Nov 6, 2022: Oct 28, Dec 1, 2023: Feb 1, More...
Oceania Sirena Cruises10 Night - Panama Potpourri - Miami Florida to Panama City Panama
Starting in Miami with stops in Key West, Cruising the Straits of Florida, Costa Maya, Harvest Caye, Santo Tomas, Roatan, Cruising the Caribbean Sea, Puerto Limon, Panama Canal Daylight Transit, Panama City
2022 Sails: Jan 22, More...
Oceania Sirena Cruises10 Night - Panama Potpourri - Panama City Panama to Miami Florida
Starting in Panama City with stops in Panama Canal Daylight Transit, Puerto Limon, Cruising the Caribbean Sea, Roatan, Santo Tomas, Harvest Caye, Costa Maya, Cozumel, Cruising the Straits of Florida, Miami
2022 Sails: Feb 1, More...


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