CruiseCompete: Easily Compare Multiple Offers from Cruise Experts
Compare offers from multiple travel agencies
1
Find your cruise
& request quotes
2
Compare members only prices,
upgrades, cabin credits & more!
3
Contact your preferred agent
for questions or to book your cruise
Over 1 million members

Panama City Cruises

Cruises that visit Central America: Panama: Panama City

Cruises that depart from Panama City

Click on a cruise ship itinerary that visits Panama City (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just Panama City), please visit: Cruise Search or try our Virtual Cruise Advisor™.





Safari Voyager Cruises10 Night - Costa Rica & PanamaŚCanal, Culture, Adventure from San Jose to Panama City
Starting in San Jose; with stops in Curo National Wildlife Refuge; Osa Conservation Area; Golfo Dulce; Coiba National Park; Granito de Oro; Gulf of Panama; Pearl Islands Archipelago; Darien Jungle; Fort San Lorenzo; Panama City
2020 Sails: Mar 9, Mar 29, Dec 28, 2021: Jan 17, Feb 6, Feb 26, Mar 18, Apr 7, More...
Safari Voyager Cruises7 Night - Unveiled WondersŚCosta Rica & Panama Canal from San Jose to Panama City
Starting in San Jose; with stops in Curo National Wildlife Refuge; Osa Conservation Area; Golfo Dulce; Granito de Oro, Coiba National Park, Panama; Panama Canal; Panama City
2020 Sails: Apr 20, May 4, 2021: Apr 24, More...
Safari Voyager Cruises7 Night - Colombia & PanamaŚCoral, Jungles, Canal from Cartagena to Panama City
Starting in Cartagena; with stops in Capurgana; Sapzurro; Guna Yala; Panama Canal; Isla Taboga; Darien Jungle; Panama City
2020 Sails: Oct 10, More...
Crystal Serenity Cruise Ship127 Night - OCY210105-127 - Ancient Dynasties & World Wonders
Starting in Miami with stops in Cruising the Caribbean Sea, Cartagena, Transit the Panama Canal, Panama City, Cruising Cent. America's Coast, Caldera, Acajutla, Cruising the Coast of Mexico, Puerto Vallarta, Cruising the USA's West Coast, San Diego, San Pedro, Cruising the North Pacific, Honolulu, Lahaina, Cruising the Pacific Ocean, Fanning Islands, Crossing Dateline- Gain 1 day, Mystery Island, Noumea, Brisbane, Cruising the Australian Coast, Arlie Beach, Townsville, Port Douglas, Cruising Great Barrier Reef, Cruising the Arafura Sea, Banda Neira, Ambon, Cruising the Celebes Sea, Kota Kinabalu, Bandar Seri Begawan, Cruising the South China Sea, Manila, Hong Kong, Hualien, Ishigaki Island, Cruising the East China Sea, Hososhima, Hiroshima, Kochi, Osaka, Shimizu, Tokyo, Cruising the Coast of Japan, Kagoshima, Nagasaki, Incheon, Cruising the Yellow Sea, Beijing/Xingang, Shanghai, Naha, Keelung, Hanoi/Hongai, Ho Chi Minh City, Singapore, Cruising the Malacca Strait, Cruising the Bay of Bengal, Yangon, Chennai, Colombo, Cruising the Arabian Sea, Mumbai, Cruising the Gulf of Oman, Dubai, Abu Dhabi, Muscat, Cruising the Gulf of Aden, Cruising the Red Sea, Safaga, Cruising the Gulf of Aqaba, Transit the Suez Canal, Cruising the Mediterranean Sea, Santorini, Cruising the Ionian Sea, Amalfi, Civitavecchia
2021 Sails: Jan 5, More...
Crystal Serenity Cruise Ship139 Night - OCY210105-139 - Ancient Dynasties & World Wonders
Starting in Miami with stops in Cruising the Caribbean Sea, Cartagena, Transit the Panama Canal, Panama City, Cruising Cent. America's Coast, Caldera, Acajutla, Cruising the Coast of Mexico, Puerto Vallarta, Cruising the USA's West Coast, San Diego, San Pedro, Cruising the North Pacific, Honolulu, Lahaina, Cruising the Pacific Ocean, Fanning Islands, Crossing Dateline- Gain 1 day, Mystery Island, Noumea, Brisbane, Cruising the Australian Coast, Arlie Beach, Townsville, Port Douglas, Cruising Great Barrier Reef, Cruising the Arafura Sea, Banda Neira, Ambon, Cruising the Celebes Sea, Kota Kinabalu, Bandar Seri Begawan, Cruising the South China Sea, Manila, Hong Kong, Hualien, Ishigaki Island, Cruising the East China Sea, Hososhima, Hiroshima, Kochi, Osaka, Shimizu, Tokyo, Cruising the Coast of Japan, Kagoshima, Nagasaki, Incheon, Cruising the Yellow Sea, Beijing/Xingang, Shanghai, Naha, Keelung, Hanoi/Hongai, Ho Chi Minh City, Singapore, Cruising the Malacca Strait, Cruising the Bay of Bengal, Yangon, Chennai, Colombo, Cruising the Arabian Sea, Mumbai, Cruising the Gulf of Oman, Dubai, Abu Dhabi, Muscat, Cruising the Gulf of Aden, Cruising the Red Sea, Safaga, Cruising the Gulf of Aqaba, Transit the Suez Canal, Cruising the Mediterranean Sea, Santorini, Cruising the Ionian Sea, Amalfi, Civitavecchia, Alghero, Ibiza, Tangier, Lisbon, Cruising the Bay of Biscay, Bordeaux, Cruising the English Channel, Dover
2021 Sails: Jan 5, More...
Crystal Serenity Cruise Ship16 Night - OCY210105-16 - Coral Sunsets & Golden Panama
Starting in Miami with stops in Cruising the Caribbean Sea, Cartagena, Transit the Panama Canal, Panama City, Cruising Cent. America's Coast, Caldera, Acajutla, Cruising the Coast of Mexico, Puerto Vallarta, Cruising the USA's West Coast, San Diego, San Pedro
2021 Sails: Jan 5, More...
Oceania Sirena Cruises10 Night - Panama Potpourri - Miami Florida to Panama City Panama
Starting in Miami with stops in Key West, Cruising the Straits of Florida, Costa Maya, Harvest Caye, Santo Tomas, Roatan, Cruising the Caribbean Sea, Puerto Limon, Panama Canal Daylight Transit, Panama City
2022 Sails: Jan 22, More...
Oceania Sirena Cruises10 Night - Panama Potpourri - Panama City Panama to Miami Florida
Starting in Panama City with stops in Panama Canal Daylight Transit, Puerto Limon, Cruising the Caribbean Sea, Roatan, Santo Tomas, Harvest Caye, Costa Maya, Cruising the Straits of Florida, Key West, Miami
2022 Sails: Feb 1, More...
Crystal Endeavor Cruises9 Night - YEN220930-09 - Boutique Caribbean & Panama Canal
Starting in West Palm Beach with stops in Harbor Island, Cockburn Town, Great Inagua Island, Port Antonio, Cruising the Caribbean Sea, Cartagena, San Blas Island, Transit the Panama Canal, Panama City
2022 Sails: Sep 30, More...
Crystal Serenity Cruise Ship10 Night - OCY221115-10 - Panama & Tropical Playgrounds
Starting in Caldera with stops in Cruising the Costa Rican Coast, Panama City, Transit the Panama Canal, Puerto LimAŤn, Cruising the Caribbean Sea, George Town, Cozumel, Miami
2022 Sails: Nov 15, More...


Panama City Cruises

Connecting cruisers with the best cruise prices on discount cruises since 2003. Privacy Policy

Cruise news from Cruise Compete, where you compare cruise prices to get the best cruise discounts and deals
Let our Virtual Cruise Advisor(TM) recommend the best cruises for you.