Panama Cruises

Cruises that visit Central America: Panama

Cruises that depart from Panama

Click on a cruise ship itinerary that visits Panama (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just Panama), please visit: Cruise Search or try our Virtual Cruise Advisor™.

Royal Caribbean, Serenade of the Seas

7 Night - Southern Caribbean Cruise
Starting in Cartagena CO, Oranjestad, Aruba, Kralendijk, Bonaire, Colon, Panama, Cartagena CO
2026 Sails: Mar 29, More...

Cunard Line, Queen Elizabeth

42 Night - Miami to Seattle
Starting in Miami, FL, San Juan, Puerto Rico, St Johns AG, Antigua, Castries, St Lucia, Bridgetown, Barbados, Philipsburg, St Maarten, Road Town, Tortola, Miami, FL, Cartagena CO, Colon, Panama, Transit the Panama Canal, Panama (Full Transit), Puntarenas, Costa Rica, Santa Cruz (for Huatulco), Mexico, Cabo San Lucas, Mexico, Los Angeles, CA, Seattle, WA, Ketchikan, AK, Sitka, AK, Glacier Bay, AK, (Scenic Cruising), Juneau, AK, Skagway, AK, Tracy Arm Fjord, AK, (Scenic Cruising), Victoria CA, Canada, Seattle, WA
2026 Sails: Apr 2, More...

Cunard Line, Queen Elizabeth

Deal link -> Special

32 Night - Panama Canal
Starting in Miami, FL, San Juan, Puerto Rico, St Johns AG, Antigua, Castries, St Lucia, Bridgetown, Barbados, Philipsburg, St Maarten, Road Town, Tortola, Miami, FL, Cartagena CO, Colon, Panama, Transit the Panama Canal, Panama (Full Transit), Puntarenas, Costa Rica, Santa Cruz (for Huatulco), Mexico, Cabo San Lucas, Mexico, Los Angeles, CA, Seattle, WA
2026 Sails: Apr 2, More...

Oceania Cruises, Oceania Insignia

10 Night - Classic Canal & Tropics
Starting in Panama City, Panama Canal Daylight Transit, Cartagena CO, Willemstad AN, Oranjestad, Montego Bay, George Town, Miami
2026 Sails: Apr 4, More...

Cunard Line, Queen Anne

25 Night - Los Angeles to Southampton
Starting in Los Angeles, CA, Puerto Quetzal, Guatemala, Transit the Panama Canal, Panama (Full Transit), Willemstad AN, Curacao, Oranjestad, Aruba, Miami, FL, Ponta Delgada, Azores, Portugal, Southampton, England, UK
2026 Sails: Apr 5, More...

Cunard Line, Queen Anne

14 Night - Los Angeles to Miami
Starting in Los Angeles, CA, Puerto Quetzal, Guatemala, Transit the Panama Canal, Panama (Full Transit), Willemstad AN, Curacao, Oranjestad, Aruba, Miami, FL
2026 Sails: Apr 5, More...

Disney Cruise Line, Disney Magic

14 Night - Westbound Panama Canal Cruise from Galveston Ending in San Diego
Starting in Galveston, Cozumel, Mexico, Cartagena ES, Panama Canal, Puerto Vallarta, Cabo San Lucas, San Diego
2026 Sails: Apr 5, More...

Holland America, Eurodam

20 Night - Panama Canal
Starting in Fort Lauderdale, Florida, Cartagena CO, Enter Panama Canal Cristobal, Cruising Panama Canal, Exit Panama Canal Balboa, Puntarenas (Puerto Caldera), Costa Rica, Acajutla, El Salvador, Puerto Quetzal, Guatemala, Puerto Vallarta, Mexico, Cabo San Lucas, Mexico, San Diego, California, Avalon, California, Vancouver, BC, CA, Seattle, Washington
2026 Sails: Apr 5, More...

Holland America, Eurodam

19 Night - Panama Canal
Starting in Fort Lauderdale, Florida, Cartagena CO, Enter Panama Canal Cristobal, Cruising Panama Canal, Exit Panama Canal Balboa, Puntarenas (Puerto Caldera), Costa Rica, Acajutla, El Salvador, Puerto Quetzal, Guatemala, Puerto Vallarta, Mexico, Cabo San Lucas, Mexico, San Diego, California, Avalon, California, Vancouver, BC, CA
2026 Sails: Apr 5, More...

Holland America, Eurodam

15 Night - Panama Canal
Starting in Fort Lauderdale, Florida, Cartagena CO, Enter Panama Canal Cristobal, Cruising Panama Canal, Exit Panama Canal Balboa, Puntarenas (Puerto Caldera), Costa Rica, Acajutla, El Salvador, Puerto Quetzal, Guatemala, Puerto Vallarta, Mexico, Cabo San Lucas, Mexico, San Diego, California
2026 Sails: Apr 5, More...

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