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Panama Cruise Departures

Cruises that depart from Central America: Panama

Cruises that visit Panama

Click on a cruise ship itinerary sailing from Panama (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just Panama), please visit: Cruise Search or try our Virtual Cruise Advisor™.

Related areas: Balboa : Colon : Fuerte Amador : Panama City

Departing from
Panama
Cruise Specials

Oceania Cruises, Oceania Insignia
Oceania Insignia10 Night - Canal & Coral Isles
Starting in Panama City, Panama Canal Daylight Transit, Cartagena CO, Puerto Limon, Roatan, Costa Maya, Mexico, Cozumel, Mexico, Miami
2026 Sails: Apr 24, More...
Royal Caribbean, Serenade of the Seas
Serenade of the Seas10 Night - Panama Canal Westward Cruise
Starting in Colon, Panama, Panama Canal (Cruising), Puntarenas, Costa Rica, Huatulco, Mexico, Puerto Vallarta, Mexico, Los Angeles, California
2026 Sails: Apr 25, More...
Royal Caribbean, Grandeur of the Seas
Grandeur of the Seas7 Night - Southern Caribbean Cruise
Starting in Colon, Panama, Cartagena CO, Oranjestad, Aruba, Willemstad AN, Curacao, Colon, Panama
2026 Sails: May 16, May 23, May 30, Jun 6, Jun 13, Jun 20, Jun 27, Jul 4, Jul 11, Jul 18, Jul 25, Aug 1, Aug 8, Aug 15, Aug 22, Aug 29, Sep 12, Sep 19, Sep 26, Oct 3, Oct 10, Oct 17, Oct 24, Oct 31, More...
Royal Caribbean, Grandeur of the Seas
Grandeur of the Seas7 Night - Southern Caribbean Cruise
Starting in Colon, Panama, Cartagena CO, Kralendijk, Bonaire, Oranjestad, Aruba, Willemstad AN, Curacao, Colon, Panama
2026 Sails: Sep 5, More...
PONANT, L'Austral
L'Austral10 Night - From Panama's Wild Beauty to Peruvian Shores
Starting in Colon, San Blas Islands, Crossing the Panama Canal, Fuerte Amador, Flamenco Island, Playa Muerto, Darien National Park, Salaverry, Callao
2026 Sails: Oct 20, More...
Scenic Luxury, Scenic Eclipse
Scenic Eclipse9 Night - Wellness Retreat - Panama City to Valparaiso
Starting in Panama City, Panama, Valparaiso, Chile
2026 Sails: Oct 26, More...
Lindblad Expeditions, National Geographic Quest
National Geographic Quest7 Night - Panama and Colombia : Exploring the Caribbean Coast
Starting in Panama City, Panama / Balboa / Embark Ship, Gatun Lake / Barro Colorado / Panama Canal Crossing, Portobelo, Guna Yala Archipelago, Capurgana and Sapzurro, Colombia, Santa Cruz de Lorica / San Antero / Tuchin, Cispata Bay / Sanguare Natural Reserve, Cartagena CO, Colombia / Disembark Ship
2026 Sails: Oct 31, More...
PONANT, Le Bellot
Le Bellot7 Night - Central America Jewels & Panama Canal
Starting in Colon, San Blas Islands, Crossing the Panama Canal, Fuerte Amador, Flamenco Island, Playa Muerto, Darien National Park, Golfito, Puntarenas
2026 Sails: Nov 7, More...
Viking Ocean, Viking Mars
Viking Mars10 Night - Classic Panama Canal Passage
Starting in Panama City (Fuerte Amador), Scenic Sailing Panama Canal, Colon, Puerto Limon, Sail the Caribbean Sea, Roatan, Belize City, Cozumel, Mexico, Sail the Caribbean Sea, Fort Lauderdale, Florida
2026 Sails: Nov 13, More...
Royal Caribbean, Grandeur of the Seas
Grandeur of the Seas10 Night - Southern Caribbean Cruise
Starting in Colon, Panama, Kralendijk, Bonaire, Oranjestad, Aruba, Willemstad AN, Curacao, Port of Spain, Trinidad, Scarborough, Tobago, Colon, Panama
2026 Sails: Nov 14, More...

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Panama Cruise Departures