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Panama Cruise Departures

Cruises that depart from Central America: Panama

Cruises that visit Panama

Click on a cruise ship itinerary sailing from Panama (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just Panama), please visit: Cruise Search or try our Virtual Cruise Advisor™.

Related areas: Balboa : Colon : Fuerte Amador : Panama City

Departing from
Panama
Cruise Specials

Windstar Cruises, Wind Spirit
Wind Spirit Cruise Ship7 Night - Costa Rica & Panama Canal
Starting in Colon, Panama Canal, Balboa / Fuerte Amador, Isla Partida, Golfo Dulce (Puerto Jimenez), Quepos, Puerto Caldera
2025 Sails: Nov 29, More...
PONANT, Le Champlain
Le Champlain Cruises10 Night - A Tropical Odyssey in Central America
Starting in Colon, Bocas del Toro, Puerto Limon, San Andres and Providencia, Water Caye, Isla Utila, La Ensenada, Santo Tomas De Castilla, Dulce River, Belize City
2025 Sails: Dec 3, More...
Royal Caribbean International (RCL), RCL Serenade of the Seas
RCL Serenade of the Seas Cruise Ship6 Night - Southern Caribbean Cruise
Starting in Colon, Panama, Cartagena CO, Oranjestad, Aruba, Willemstad AN, Curacao, Colon, Panama
2025 Sails: Dec 6, More...
Lindblad Expeditions, National Geographic Quest
National Geographic Quest Cruises7 Night - The Panama Canal, Pearl Islands and Darien Jungle
Starting in Panama City, Panama / Colon / Embark Ship, Portobelo / Panama Canal Transit, Gatun Lake / Panama Canal Transit, Punta Patino Nature Reserve, Playa Muerto, Darien National Park, Pearl Islands, Balboa / Disembark Ship / Panama City, Panama
2025 Sails: Dec 7, 2026: Jan 9, Dec 6, 2028: Mar 9, More...
Royal Caribbean International (RCL), RCL Serenade of the Seas
RCL Serenade of the Seas Cruise Ship8 Night - Southern Caribbean Cruise
Starting in Colon, Panama, Cartagena CO, Kralendijk, Bonaire, Oranjestad, Aruba, Willemstad AN, Curacao, Colon, Panama
2025 Sails: Dec 12, More...
Seabourn, Seabourn Encore
Seabourn Encore Cruises29 Night - Pacific Crossing & Treasures of Japan
Starting in Fuerte Amador (Panama City), Panama, Puntarenas (Puerto Caldera), Costa Rica, Puerto Chiapas, Mexico, Puerto Vallarta, Mexico, Honolulu, Hawaii, Nawiliwili, Kauai, Hawaii, Cross International Dateline, Tokyo, Japan
2025 Sails: Dec 12, More...
Seabourn, Seabourn Encore
Seabourn Encore Cruises17 Night - Costa Rica, Mexico & Hawaiian Nights
Starting in Fuerte Amador (Panama City), Panama, Puntarenas (Puerto Caldera), Costa Rica, Puerto Chiapas, Mexico, Puerto Vallarta, Mexico, Honolulu, Hawaii
2025 Sails: Dec 12, More...
Star Clippers, Star Clipper
Star Clipper Cruise Ship7 Night - Panama to Costa Rica
Starting in Balboa (Isla Flamenco), Panama, San Jose Island / Pearl Islands, Panama, Isla Iguana, Panama, Coiba National Park, Panama, Golfito, Costa Rica, Quepos, Costa Rica, Islas Tortugas, Costa Rica, Puerto Caldera, Costa Rica
2025 Sails: Dec 13, 2026: Dec 19, More...
Windstar Cruises, Star Pride
Star Pride Cruises7 Night - Costa Rica & Panama Canal
Starting in Colon, Panama Canal, Balboa / Fuerte Amador, Isla Partida, Golfo Dulce (Puerto Jimenez), Quepos, Puerto Caldera
2025 Sails: Dec 13, 2026: Feb 9, Feb 23, More...
Wind Spirit Cruise Ship7 Night - Enchanting Colombia and Panamanian Islands
Starting in Colon, San Blas, Panama, Cartagena CO, Oranjestad
2025 Sails: Dec 13, More...

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Panama Cruise Departures