CruiseCompete: Easily Compare Multiple Offers from Cruise Experts
Compare offers from multiple travel agencies
Find your cruise
& request quotes
Compare members only prices,
upgrades, cabin credits & more!
Contact your preferred agent
for questions or to book your cruise
Over 1 million members

Panama Cruise Departures

Cruises that depart from Central America: Panama

Cruises that visit Panama

Click on a cruise ship itinerary sailing from Panama (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just Panama), please visit: Cruise Search or try our Virtual Cruise Advisor™.

Related areas: Balboa : Colon : Flamenco Marina : Fuerte Amador : Panama City

Safari Voyager Cruises7 Night - Colombia & Panama—Coral, Jungles, Canal from Panama City to Cartagena
Starting in Panama City; with stops in Darien Jungle; Isla Taboga; Panama Canal; Guna Yala; Capurgana; Sapzurro; Cartagena
2020 Sails: Oct 3, Oct 17, More...
Silver Explorer Cruise Ship8 Night - E1201031008 - Colon to Guayaquil
Starting in Colon with stops in Panama Canal Transit, Darien Jungle, Bahia Solano, Utria National Park, Gorgona Island, Isla de la Plata, Machala, Guayaquil
2020 Sails: Oct 31, More...
Royal Clipper Cruise Ship14 Night - Panama Canal from Panama to Antigua
Starting in Balboa (Isla Flamenco), Panama; with stops in Panama Canal Transit; San Blas Islands, Panama; At sea; Cartagena de Indias, Colombia; Santa Marta, Colombia; At sea; Oranjestad, Aruba; Willemstad, Curacao; Kralendijk, Bonaire; At sea; St. George's, Grenada; Soufriere Bay, St. Lucia; Deshaies, Guadeloupe; St. John's, Antigua
2020 Sails: Nov 21, More...
Wind Star Cruise Tours11 Night - Monteverde Cloud Forest & Arenal Volcano Cruise Tour - Colon to San Jose
Cruise Ports: Departing from Colon, Panama with stops in; Panama Canal, Panama; Balboa / Fuerte Amador, Panama; Isla Parida, Panama; Puerto Jimenez (Gulfo Dulce), Costa Rica; Quepos, Cost Rica; Puerto Caldera, Costa Rica; Land Tour: Monteverde; Arenal; San Jose, Costa Rica
2020 Sails: Nov 28, Dec 12, Dec 26, 2021: Jan 9, Jan 23, Feb 6, More...
Safari Voyager Cruises10 Night - Costa Rica & Panama—Canal, Culture, Adventure from Panama City to San Jose
Starting in Panama City; with stops in Fort San Lorenzo; Panama Canal; Darien Jungle; Pearl Islands Archipelago; Gulf of Panama; Granito de Oro; Coiba National Park; Golfo Dulce; Osa Conservation Area; Curo National Wildlife Refuge; San Jose
2020 Sails: Dec 18, 2021: Jan 7, Jan 27, Feb 16, Mar 8, Mar 28, More...
S/C Panorama Cruise Ship7 Night - /21 - Crossing the Panama Canal: Panama to Costa Rica - Panorama
Starting in Colon 2000 Port with stops in Flamenco Marina, Playa Muerto, Coiba Islands, Golfito, Playa Biesanz, Drake Bay, Puerto Caldera
2020 Sails: Dec 19, 2021: Jan 2, More...
Le Champlain Cruises7 Night - Natural & Cultural History of Central America from Colón to Puerto Caldera
Starting in Colon; with stops in San Blas Islands; Playa Muerto, Darien National Park; Manuel Antonio National Park; Curú Wildlife Refuge; Puerto Caldera
2020 Sails: Dec 29, More...
Le Dumont-D'Urville Cruises7 Night - Tropical Rainforests & the Panama Canal from Colón to Puerto Caldera
Starting in Colón; with stops in San Blas Islands; Crossing the Panama Canal; Muerto, Darien National Park; Manuel Antonio National Park; Curu Wildlife Refuge; Tortuga Island; Puerto Caldera
2021 Sails: Jan 4, More...
Le Champlain Cruises9 Night - Between Panama and Martinique Cruise From Colon, Panama to Fort de France, Martinique
Starting in Colon, with stops in San Blas Islands, Cartagena, St George's, Mayreau, Soufriere , Fort de France
2021 Sails: Jan 12, More...
Wind Star Cruise Ship7 Night - Colon to Puerto Caldera-Wind Star-
Starting in Colon with stops in Panama Canal, Balboa / Fuerte Amador, Isla Parida, Puerto Jimenez, Quepos, Puerto Caldera
2021 Sails: Jan 23, More...

Panama Cruise Departures

Connecting cruisers with the best cruise prices on discount cruises since 2003. Privacy Policy

Cruise news from Cruise Compete, where you compare cruise prices to get the best cruise discounts and deals
Let our Virtual Cruise Advisor(TM) recommend the best cruises for you.