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Panama Cruise Departures

Cruises that depart from Central America: Panama

Cruises that visit Panama

Click on a cruise ship itinerary sailing from Panama (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just Panama), please visit: Cruise Search or try our Virtual Cruise Advisor™.

Related areas: Balboa : Colon : Fuerte Amador : Panama City

Departing from
Panama
Cruise Specials

Lindblad Expeditions, National Geographic Quest
National Geographic Quest7 Night - Costa Rica and the Panama Canal
Starting in Panama City, Panama / Colon / Embark Ship, Gatun Lake / Panama Canal Transit, Gulf of Panama Islets, Coiba National Park, Panama, Golfo Dulce / Osa Peninsula, Corcovado National Park, Puerto Caldera / Disembark Ship / San Jose
2026 Sails: Mar 2, Mar 21, Dec 20, 2027: Jan 3, Feb 6, Feb 20, Mar 6, Mar 20, Dec 4, Dec 23, 2028: Jan 6, Feb 5, Feb 19, Mar 23, Apr 6, More...
PONANT, Le Champlain
Le Champlain10 Night - Secrets of Central America
Starting in Colon, Fort San Lorenzo (Colon), Colon, San Blas Islands, Crossing the Panama Canal, Pearls Islands, Pacheca Island, Playa Muerto, Darien National Park, Coiba Island, Rio Esquinas, Drake Bay, Curu Wildlife Refuge, Puntarenas
2026 Sails: Mar 5, More...
Royal Caribbean, Serenade of the Seas
Serenade of the Seas7 Night - Southern Caribbean Cruise
Starting in Colon, Panama, Cartagena CO, Oranjestad, Aruba, Willemstad AN, Curacao, Colon, Panama
2026 Sails: Mar 7, More...
Windstar, Star Pride
Star Pride6 Night - Panama's Pristine Caribbean
Starting in Colon, Bocas del Toro, San Blas, Panama, Cartagena CO, Oranjestad
2026 Sails: Mar 9, More...
Sea Cloud, Sea Cloud Spirit
Sea Cloud Spirit13 Night - Central America from Colon to Cozumel
Starting in Colon, San Blas Islands, Bocas del Toro, Puerto Limon, Isla Guanaja, French Key / Islas De La Bahia, Belize City, Lighthouse Reef / Half Moon Caye, Cozumel, Mexico
2026 Sails: Mar 13, More...
Royal Caribbean, Serenade of the Seas
Serenade of the Seas7 Night - Southern Caribbean Cruise
Starting in Colon, Panama, Cartagena CO, Willemstad AN, Curacao, Oranjestad, Aruba, Colon, Panama
2026 Sails: Mar 14, Apr 11, More...
Azamara Cruises, Azamara Quest
Azamara Quest11 Night - Panama Canal & Southern Caribbean Cruise : Cartagena, Aruba & Curacao
Starting in Panama City (Fuerte Amador), Panama Canal (Cruising), Cartagena CO, Santa Marta, Oranjestad, Willemstad AN, Kralendijk, Cabo Rojo, Miami, Florida
2026 Sails: Mar 15, More...
Royal Caribbean, Serenade of the Seas
Serenade of the Seas7 Night - Southern Caribbean Cruise
Starting in Colon, Panama, Cartagena CO, Oranjestad, Aruba, Willemstad AN, Curacao, Colon, Panama
2026 Sails: Mar 21, Apr 4, More...
PONANT, Le Champlain
Le Champlain12 Night - Panama, Colombia & Caribbean Islands
Starting in Colon, Portobelo, San Blas Islands, Cartagena, Santa Marta, Bonaire, Mayreau Island, Union Island, Pigeon Island Beach, Soufriere, Les Saintes, Fort-de-France
2026 Sails: Mar 25, More...
Royal Caribbean, Serenade of the Seas
Serenade of the Seas7 Night - Southern Caribbean Cruise
Starting in Colon, Panama, Cartagena CO, Oranjestad, Aruba, Kralendijk, Bonaire, Colon, Panama
2026 Sails: Mar 28, More...

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Panama Cruise Departures