Colon Cruises
Cruises that visit Central America: Panama: Colon
Cruises that depart from Colon
7 Night - Southern Caribbean Cruise
Starting in Cartagena CO, Oranjestad, Aruba, Willemstad AN, Curacao, Colon, Panama, Cartagena CO
2026 Sails: May 17, May 24, May 31, Jun 7, Jun 14, Jun 21, Jun 28, Jul 5, Jul 12, Jul 19, Jul 26, Aug 2, Aug 9, Aug 16, Aug 23, Aug 30, Sep 13, Sep 20, Sep 27, Oct 4, Oct 11, Oct 18, Oct 25, Nov 1, More...7 Night - Southern Caribbean Cruise
Starting in Cartagena CO, Kralendijk, Bonaire, Oranjestad, Aruba, Willemstad AN, Curacao, Colon, Panama, Cartagena CO
2026 Sails: Sep 6, More...
26 Night - Msc Grand Voyages
Starting in Seattle, Washington, Ketchikan, Alaska, Sitka, Alaska, Endicott Arm and Dawes Glacier, Juneau, Alaska, Victoria CA, Canada, Seattle, Washington, Los Angeles, San Diego, Cabo San Lucas, Mexico, Puntarenas (San Jose), Costa Rica, Cruising Panama Canal, Colon, Panama, Cartagena CO, Colombia, Miami, Florida
2026 Sails: Sep 21, More...19 Night - Msc Grand Voyages
Starting in Seattle, Washington, Los Angeles, San Diego, Cabo San Lucas, Mexico, Puntarenas (San Jose), Costa Rica, Cruising Panama Canal, Colon, Panama, Cartagena CO, Miami, Florida
2026 Sails: Sep 28, More...24 Night - Msc Grand Voyages
Starting in Seattle, Washington, Los Angeles, San Diego, Cabo San Lucas, Mexico, Puntarenas (San Jose), Costa Rica, Cruising Panama Canal, Colon, Panama, Cartagena CO, Miami, Florida, George Town, Cayman Islands, Ocho Rios, Jamaica, Miami, Florida
2026 Sails: Sep 28, More...
12 Night - Panama Canal Discovery : Costa Rica & Greater Antilles
Starting in Fort Lauderdale, Florida, RelaxAway, Half Moon Cay, Bahamas, Oranjestad, Aruba, Cartagena CO, Enter Panama Canal Cristobal, Cruising Panama Canal and Gatun Lake, Gatun Lake, Panama, Cruising Gatun Lake and Panama Canal, Exit Panama Canal Cristobal, Colon, Panama, Puerto Limon (San Jose), Costa Rica, Georgetown, Cayman Islands, Fort Lauderdale, Florida
2026 Sails: Oct 18, Dec 27, 2027: Jan 17, Feb 7, Feb 28, Mar 21, More...21 Night - Panama Canal & Southern Caribbean : Abc Islands
Starting in Fort Lauderdale, Florida, RelaxAway, Half Moon Cay, Bahamas, Oranjestad, Aruba, Cartagena CO, Enter Panama Canal Cristobal, Cruising Panama Canal and Gatun Lake, Gatun Lake, Panama, Cruising Gatun Lake and Panama Canal, Exit Panama Canal Cristobal, Colon, Panama, Puerto Limon (San Jose), Costa Rica, Georgetown, Cayman Islands, Fort Lauderdale, Florida, Cabo Rojo, Dominican Republic, Willemstad AN, Curacao, Oranjestad, Aruba, RelaxAway, Half Moon Cay, Bahamas, Fort Lauderdale, Florida
2026 Sails: Oct 18, More...
14 Night - Panama Canal & Central America
Starting in Fort Lauderdale, Florida, Sail the Caribbean Sea, Montego Bay, Sail the Caribbean Sea, Scenic Sailing Panama Canal, Colon, Puerto Limon, Sail the Caribbean Sea, Roatan, Belize City, Cozumel, Mexico, Sail the Caribbean Sea, Fort Lauderdale, Florida
2026 Sails: Oct 20, Nov 23, 2027: Jan 10, More...21 Night - Caribbean and Antilles
Starting in Miami, Florida, Kralendijk, Bonaire, Oranjestad, Aruba, Willemstad AN, Cabo Rojo, Dominican Republic, Ocho Rios, Jamaica, Miami, Florida, Ocho Rios, Jamaica, Cartagena CO, Colon, Panama, Puerto Limon, Costa Rica, Isla De Roatan, Honduras, Belize City, Belize, Miami, Florida
2026 Sails: Oct 22, 2027: Oct 21, More...
10 Night - Caribbean & Panama
Starting in Galveston, Tx, Cozumel, Mexico, Limon, Costa Rica, Colon (Panama Canal), Panama, Isla Tropicale, Roatan, Galveston, Tx
2026 Sails: Oct 26, Dec 7, 2027: Jan 18, Mar 5, Apr 26, More...
Cruises that visit Central America: Panama: Colon
Cruises that depart from Colon
Click on a cruise ship itinerary that visits Colon (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just Colon), please visit: Cruise Search or try our Virtual Cruise Advisor™.
7 Night - Southern Caribbean CruiseStarting in Cartagena CO, Oranjestad, Aruba, Willemstad AN, Curacao, Colon, Panama, Cartagena CO
2026 Sails: May 17, May 24, May 31, Jun 7, Jun 14, Jun 21, Jun 28, Jul 5, Jul 12, Jul 19, Jul 26, Aug 2, Aug 9, Aug 16, Aug 23, Aug 30, Sep 13, Sep 20, Sep 27, Oct 4, Oct 11, Oct 18, Oct 25, Nov 1, More...
7 Night - Southern Caribbean CruiseStarting in Cartagena CO, Kralendijk, Bonaire, Oranjestad, Aruba, Willemstad AN, Curacao, Colon, Panama, Cartagena CO
2026 Sails: Sep 6, More...
26 Night - Msc Grand VoyagesStarting in Seattle, Washington, Ketchikan, Alaska, Sitka, Alaska, Endicott Arm and Dawes Glacier, Juneau, Alaska, Victoria CA, Canada, Seattle, Washington, Los Angeles, San Diego, Cabo San Lucas, Mexico, Puntarenas (San Jose), Costa Rica, Cruising Panama Canal, Colon, Panama, Cartagena CO, Colombia, Miami, Florida
2026 Sails: Sep 21, More...
19 Night - Msc Grand VoyagesStarting in Seattle, Washington, Los Angeles, San Diego, Cabo San Lucas, Mexico, Puntarenas (San Jose), Costa Rica, Cruising Panama Canal, Colon, Panama, Cartagena CO, Miami, Florida
2026 Sails: Sep 28, More...
24 Night - Msc Grand VoyagesStarting in Seattle, Washington, Los Angeles, San Diego, Cabo San Lucas, Mexico, Puntarenas (San Jose), Costa Rica, Cruising Panama Canal, Colon, Panama, Cartagena CO, Miami, Florida, George Town, Cayman Islands, Ocho Rios, Jamaica, Miami, Florida
2026 Sails: Sep 28, More...
12 Night - Panama Canal Discovery : Costa Rica & Greater AntillesStarting in Fort Lauderdale, Florida, RelaxAway, Half Moon Cay, Bahamas, Oranjestad, Aruba, Cartagena CO, Enter Panama Canal Cristobal, Cruising Panama Canal and Gatun Lake, Gatun Lake, Panama, Cruising Gatun Lake and Panama Canal, Exit Panama Canal Cristobal, Colon, Panama, Puerto Limon (San Jose), Costa Rica, Georgetown, Cayman Islands, Fort Lauderdale, Florida
2026 Sails: Oct 18, Dec 27, 2027: Jan 17, Feb 7, Feb 28, Mar 21, More...
21 Night - Panama Canal & Southern Caribbean : Abc IslandsStarting in Fort Lauderdale, Florida, RelaxAway, Half Moon Cay, Bahamas, Oranjestad, Aruba, Cartagena CO, Enter Panama Canal Cristobal, Cruising Panama Canal and Gatun Lake, Gatun Lake, Panama, Cruising Gatun Lake and Panama Canal, Exit Panama Canal Cristobal, Colon, Panama, Puerto Limon (San Jose), Costa Rica, Georgetown, Cayman Islands, Fort Lauderdale, Florida, Cabo Rojo, Dominican Republic, Willemstad AN, Curacao, Oranjestad, Aruba, RelaxAway, Half Moon Cay, Bahamas, Fort Lauderdale, Florida
2026 Sails: Oct 18, More...
14 Night - Panama Canal & Central AmericaStarting in Fort Lauderdale, Florida, Sail the Caribbean Sea, Montego Bay, Sail the Caribbean Sea, Scenic Sailing Panama Canal, Colon, Puerto Limon, Sail the Caribbean Sea, Roatan, Belize City, Cozumel, Mexico, Sail the Caribbean Sea, Fort Lauderdale, Florida
2026 Sails: Oct 20, Nov 23, 2027: Jan 10, More...
21 Night - Caribbean and AntillesStarting in Miami, Florida, Kralendijk, Bonaire, Oranjestad, Aruba, Willemstad AN, Cabo Rojo, Dominican Republic, Ocho Rios, Jamaica, Miami, Florida, Ocho Rios, Jamaica, Cartagena CO, Colon, Panama, Puerto Limon, Costa Rica, Isla De Roatan, Honduras, Belize City, Belize, Miami, Florida
2026 Sails: Oct 22, 2027: Oct 21, More...
10 Night - Caribbean & PanamaStarting in Galveston, Tx, Cozumel, Mexico, Limon, Costa Rica, Colon (Panama Canal), Panama, Isla Tropicale, Roatan, Galveston, Tx
2026 Sails: Oct 26, Dec 7, 2027: Jan 18, Mar 5, Apr 26, More...
