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Colon Cruises

Cruises that visit Central America: Panama: Colon

Cruises that depart from Colon

Click on a cruise ship itinerary that visits Colon (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just Colon), please visit: Cruise Search or try our Virtual Cruise Advisor™.



Norwegian Cruise Line, Norwegian Jewel
Norwegian Jewel11 Night - Panama Canal - Miami
Starting in Miami, Fl, George Town, Cayman Islands, Cartagena CO, Panama Canal Gatun Lake, Panama, Colon, Panama, Puerto Limon, Costa Rica, Belize City, Belize, Cozumel, Mexico, Miami, Fl
2026 Sails: Mar 15, More...
PONANT, Le Champlain
Le Champlain10 Night - Secrets of Central America
Starting in Puntarenas, Curu Wildlife Refuge, Drake Bay, Rio Esquinas, Coiba Island, Playa Muerto, Darien National Park, Pearls Islands, Pacheca Island, Crossing the Panama Canal, San Blas Islands, Fort San Lorenzo (Colon), Colon
2026 Sails: Mar 15, More...
Royal Caribbean, Serenade of the Seas
Serenade of the Seas7 Night - Southern Caribbean Cruise
Starting in Cartagena CO, Willemstad AN, Curacao, Oranjestad, Aruba, Colon, Panama, Cartagena CO
2026 Sails: Mar 15, Apr 12, More...
Celebrity Cruises, Celebrity Ascent
Celebrity Ascent11 Night - Panama Canal & Southern Caribbean
Starting in Fort Lauderdale, Florida, Cartagena CO, Panama Canal (Cruising), Colon, Panama, Oranjestad, Aruba, Willemstad AN, Curacao, Kralendijk, Bonaire, Fort Lauderdale, Florida
2026 Sails: Mar 16, More...
Princess Cruises, Caribbean Princess
Caribbean Princess12 Night - Southern Caribbean with Panama
Starting in Fort Lauderdale, Florida, Aruba, Curacao, Cartagena CO, Colon, Panama, Limon, Costa Rica, Grand Cayman, Cayman Islands, Fort Lauderdale, Florida
2026 Sails: Mar 17, More...
Virgin Voyages, Brilliant Lady
Brilliant Lady16 Night - Panama Canal & Pacific Wonders
Starting in Miami, Florida, Cartagena CO, Colon, Panama, Panama Canal (Cruising), Panama, Puntarenas, Costa Rica, Puerto Quetzal, Guatemala, Cabo San Lucas, Mexico, Los Angeles, California
2026 Sails: Mar 21, More...
Royal Caribbean, Serenade of the Seas
Serenade of the Seas7 Night - Southern Caribbean Cruise
Starting in Cartagena CO, Oranjestad, Aruba, Willemstad AN, Curacao, Colon, Panama, Cartagena CO
2026 Sails: Mar 22, Apr 5, More...
Oceania Cruises, Oceania Insignia
Oceania Insignia20 Night - Panama Canal Connoisseur
Starting in Tampa, Cozumel, Mexico, Costa Maya, Mexico, Belize City, Roatan, Puerto Limon, Colon, Panama Canal Daylight Transit, Panama City, Panama Canal Daylight Transit, Cartagena CO, Willemstad AN, Oranjestad, Montego Bay, George Town, Miami
2026 Sails: Mar 25, More...
Oceania Cruises, Oceania Insignia
Oceania Insignia10 Night - Palms & Panama Canal
Starting in Tampa, Cozumel, Mexico, Costa Maya, Mexico, Belize City, Roatan, Puerto Limon, Colon, Panama Canal Daylight Transit, Panama City
2026 Sails: Mar 25, More...
MSC Cruises, MSC Divina
MSC Divina11 Night - Caribbean and Antilles
Starting in Miami, Florida, Ocho Rios, Jamaica, Oranjestad, Aruba, Cartagena CO, Colon, Panama, Isla De Roatan, Honduras, Ocean Cay Msc Marine Reserve, Bahamas, Miami, Florida
2026 Sails: Mar 29, More...

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Colon Cruises