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Panama Cruises

Cruises that visit Central America: Panama

Cruises that depart from Panama

Click on a cruise ship itinerary that visits Panama (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just Panama), please visit: Cruise Search or try our Virtual Cruise Advisor™.

Related areas: Balboa : Barro Colorado Island : Bocas del Toro : Cayos Limones : Cebaco Island : Chiriqui Lagoon : Coiba Island : Colon : Cristobal : Darien : Flamenco Island : Fort San Lorenzo : Fuerte Amador : Gatun : Gulf of Panama : Guna Yala : Isla Iguana : Lemon Cay : Pacheca Island : Panama Canal : Panama City : Parida Island : Pearl Islands : Playa Muerto : Portobelo : Punta Patino : San Blas Islands : San Jose Island

Panama
Cruise Specials

Royal Caribbean, Serenade of the Seas
Serenade of the Seas7 Night - Southern Caribbean Cruise
Starting in Cartagena CO, Oranjestad, Aruba, Willemstad AN, Curacao, Colon, Panama, Cartagena CO
2026 Sails: Mar 8, More...
Windstar, Star Pride
Star Pride6 Night - Panama's Pristine Caribbean
Starting in Colon, Bocas del Toro, San Blas, Panama, Cartagena CO, Oranjestad
2026 Sails: Mar 9, More...
Norwegian Cruise Line, Norwegian Jade
Norwegian Jade17 Night - Repo - Panama Canal
Starting in Callao / Lima, Peru, Salaverry / Trujillo, Peru, Manta, Ecuador, Panama City, Panama, Puntarenas / Puerto Caldera, Costa Rica, Acajutla, El Salvador, Puerto Quetzal, Guatemala, Huatulco, Mexico, Acapulco, Mexico, Manzanillo, Mexico, Mazatlan, Mexico, Cabo San Lucas, Mexico, San Diego, Ca
2026 Sails: Mar 11, More...
Sea Cloud, Sea Cloud Spirit
Sea Cloud Spirit13 Night - Central America from Colon to Cozumel
Starting in Colon, San Blas Islands, Bocas del Toro, Puerto Limon, Isla Guanaja, French Key / Islas De La Bahia, Belize City, Lighthouse Reef / Half Moon Caye, Cozumel, Mexico
2026 Sails: Mar 13, More...
Carnival Cruise Lines, Carnival Miracle
Carnival Miracle8 Night - Caribbean & Panama
Starting in Tampa, Fl, Limon, Costa Rica, Colon (Panama Canal), Panama, Grand Cayman, Cayman Islands, Tampa, Fl
2026 Sails: Mar 14, More...
Norwegian Cruise Line, Norwegian Jewel
Norwegian Jewel11 Night - Panama Canal - Miami
Starting in Miami, Fl, George Town, Cayman Islands, Cartagena CO, Panama Canal Gatun Lake, Panama, Colon, Panama, Puerto Limon, Costa Rica, Belize City, Belize, Cozumel, Mexico, Miami, Fl
2026 Sails: Mar 15, More...
Royal Caribbean, Serenade of the Seas
Serenade of the Seas7 Night - Southern Caribbean Cruise
Starting in Cartagena CO, Willemstad AN, Curacao, Oranjestad, Aruba, Colon, Panama, Cartagena CO
2026 Sails: Mar 15, Apr 12, More...
Carnival Cruise Lines, Carnival Legend
Carnival Legend10 Night - Caribbean & Panama
Starting in Galveston, Tx, Cozumel, Mexico, Limon, Costa Rica, Colon (Panama Canal), Panama, Mahogany Bay, Roatan, Galveston, Tx
2026 Sails: Mar 16, More...
Celebrity Cruises, Celebrity Ascent
Celebrity Ascent11 Night - Panama Canal & Southern Caribbean
Starting in Fort Lauderdale, Florida, Cartagena CO, Panama Canal (Cruising), Colon, Panama, Oranjestad, Aruba, Willemstad AN, Curacao, Kralendijk, Bonaire, Fort Lauderdale, Florida
2026 Sails: Mar 16, More...
Princess Cruises, Caribbean Princess
Caribbean Princess12 Night - Southern Caribbean with Panama
Starting in Fort Lauderdale, Florida, Aruba, Curacao, Cartagena CO, Colon, Panama, Limon, Costa Rica, Grand Cayman, Cayman Islands, Fort Lauderdale, Florida
2026 Sails: Mar 17, More...

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Panama Cruises