Panama Cruises

Cruises that visit Central America: Panama

Cruises that depart from Panama

See all River Cruises that visit Panama

Click on a cruise ship itinerary that visits Panama (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just Panama), please visit: Cruise Search or try our Virtual Cruise Advisor™.

Princess Cruises, Coral Princess

16 Night - Panama Canal - Ocean to Ocean
Starting in Los Angeles, California, Puerto Vallarta, Mexico, Huatulco, Mexico, Puerto Chiapas, Mexico, Puntarenas, Costa Rica, Fuerte Amador, Panama (for Panama City), Panama Canal Full Transit Historic Locks, Aruba, Fort Lauderdale, Florida
2026 Sails: Sep 29, More...

Celebrity Cruises, Celebrity Summit

17 Night - Panama Canal Eastbound Cruise
Starting in Los Angeles, California, Puerto Vallarta, Mexico, Puerto Quetzal, Guatemala, Puntarenas, Costa Rica, Panama Canal (Cruising), Cartagena CO, Ocho Rios, Jamaica, George Town, Grand Cayman, Tampa, Florida
2026 Sails: Oct 1, More...

Holland America, Nieuw Amsterdam

16 Night - Panama Canal
Starting in San Diego, California, Puerto Vallarta, Mexico, Huatulco, Mexico, Puerto Chiapas, Mexico, Puerto Quetzal, Guatemala, Acajutla, El Salvador, Enter Panama Canal Balboa, Cruising Panama Canal, Exit Panama Canal Cristobal, Cartagena CO, RelaxAway, Half Moon Cay, Bahamas, Fort Lauderdale, Florida
2026 Sails: Oct 2, More...

MSC Cruises, MSC Poesia

15 Night - Msc Grand Voyages
Starting in Los Angeles, San Diego, Cabo San Lucas, Mexico, Puntarenas (San Jose), Costa Rica, Cruising Panama Canal, Colon, Panama, Cartagena CO, Colombia, Miami, Florida
2026 Sails: Oct 2, More...

Holland America, Eurodam

21 Night - Panama Canal
Starting in Seattle, Washington, Vancouver, BC, CA, Santa Barbara, California, San Diego, California, Cabo San Lucas, Mexico, Acapulco, Guerrero, Mexico, Huatulco, Mexico, Puerto Chiapas, Mexico, Puerto Quetzal, Guatemala, Puntarenas (Puerto Caldera), Costa Rica, Enter Panama Canal Balboa, Cruising Panama Canal, Exit Panama Canal Cristobal, Oranjestad, Aruba, Fort Lauderdale, Florida
2026 Sails: Oct 3, More...

MSC Cruises, MSC Poesia

14 Night - Msc Grand Voyages
Starting in San Diego, Cabo San Lucas, Mexico, Puntarenas (San Jose), Costa Rica, Cruising Panama Canal, Colon, Panama, Cartagena CO, Colombia, Miami, Florida
2026 Sails: Oct 3, More...

Holland America, Eurodam

20 Night - Panama Canal
Starting in Vancouver, BC, CA, Santa Barbara, California, San Diego, California, Cabo San Lucas, Mexico, Acapulco, Guerrero, Mexico, Huatulco, Mexico, Puerto Chiapas, Mexico, Puerto Quetzal, Guatemala, Puntarenas (Puerto Caldera), Costa Rica, Enter Panama Canal Balboa, Cruising Panama Canal, Exit Panama Canal Cristobal, Oranjestad, Aruba, Fort Lauderdale, Florida
2026 Sails: Oct 4, More...

Princess Cruises, Star Princess

16 Night - Panama Canal - Ocean to Ocean
Starting in Los Angeles, California, Cabo San Lucas, Mexico, Mazatlan, Mexico, Fuerte Amador, Panama (for Panama City), Panama Canal Full Transit New Locks, Aruba, Fort Lauderdale, Florida
2026 Sails: Oct 4, More...

Scenic Luxury, Scenic Eclipse

21 Night - Ultimate America's Historic Journey to Panama
Starting in New York, Wilmington, Delaware / Chesapeake and Delaware Canal, Baltimore, Maryland, Yorktown, Virginia, Wilmington, North Carolina, Charleston, South Carolina, Miami, Florida, Key West, Florida, Nassau, Bahamas, Staniel Cay, Bahamas, San Salvador Island, Bahamas, Cabo de La Vela, Colombia, Cartagena CO, San Blas, Panama, Bocas Del Toro, Panama, Panama Canal Transit / Panama City, Panama, Panama City, Panama
2026 Sails: Oct 5, More...

Norwegian Cruise Line, Norwegian Joy

16 Night - Repo - Panama Canal
Starting in Los Angeles, Ca, Cabo San Lucas, Mexico, Acapulco, Mexico, Puerto Quetzal, Guatemala, Puerto Caldera / Puntarenas, Costa Rica, Panama City, Panama, Transit Panama Canal / At Sea, Cartagena CO, Ocho Rios, Jamaica, Miami, Fl
2026 Sails: Oct 7, More...

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