Panama Cruises

Cruises that visit Central America: Panama

Cruises that depart from Panama

See all River Cruises that visit Panama

Click on a cruise ship itinerary that visits Panama (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just Panama), please visit: Cruise Search or try our Virtual Cruise Advisor™.

Norwegian Cruise Line, Norwegian Encore

22 Night - Repo - Panama Canal
Starting in Miami, Fl, Cartagena CO, Panama City, Panama, Transit Panama Canal / At Sea, Panama City, Panama, Puerto Caldera / Puntarenas, Costa Rica, Puerto Quetzal, Guatemala, Acapulco, Mexico, Puerto Vallarta, Mexico, Cabo San Lucas, Mexico, San Francisco, Ca, Astoria, Or, Victoria CA, Canada, Seattle, Wa
2026 Sails: Apr 11, More...

AmaWaterways Tours, AmaMelodia Tours

13 Night - Magic of Colombia with in Medellin Pre Cruise and in Panama City Post Cruise
Starting in Medellin, Barranquilla, Medellin, San Felipe, Magangue, Mompox, Calamar, Manzini, Cartagena CO, Colombia, Panama City
2026 Sails: Apr 12, Apr 26, May 10, May 24, Jun 7, Jul 19, Aug 2, Aug 16, Aug 30, Sep 13, Sep 27, Oct 25, Nov 8, Nov 22, Dec 6, More...

Royal Caribbean, Serenade of the Seas

7 Night - Southern Caribbean Cruise
Starting in Cartagena CO, Willemstad AN, Curacao, Oranjestad, Aruba, Colon, Panama, Cartagena CO
2026 Sails: Apr 12, More...

Celebrity Cruises, Celebrity Summit

17 Night - Panama Canal Westward Cruise
Starting in Fort Lauderdale, Florida, George Town, Grand Cayman, Cartagena CO, Colon, Panama, Panama Canal (Cruising), Puntarenas, Costa Rica, Puerto Quetzal, Guatemala, Puerto Vallarta, Mexico, Mazatlan, Mexico, Los Angeles, California
2026 Sails: Apr 13, More...

Princess Cruises, Star Princess

20 Night - Panama Canal - Ocean to Ocean
Starting in Fort Lauderdale, Florida, Aruba, Panama Canal Full Transit New Locks, Fuerte Amador, Panama (for Panama City), Mazatlan, Mexico, Cabo San Lucas, Mexico, Los Angeles, California, Seattle, Washington
2026 Sails: Apr 13, More...

Scenic Luxury, Scenic Eclipse II

11 Night - Panama Canal & the Alluring Islands of the Caribbean
Starting in Panama City, Panama, Panama Canal Transit, Portobelo, Panama, Cayos Limones, San Blas Islands, Panama, Cartagena CO, Oranjestad, Aruba, Willemstad AN, Curacao, Klein Curacao, Curacao, Tobago Cays, St Vincent and the Grenadines, Bridgetown, Barbados
2026 Sails: Apr 13, More...

Windstar, Star Seeker

7 Night - Costa Rica & Panama Canal
Starting in Colon, Panama Canal, Balboa / Fuerte Amador, Isla Partida, Golfo Dulce (Puerto Jimenez), Quepos, Puerto Caldera
2026 Sails: Apr 13, More...

Windstar, Star Seeker

15 Night - Star Collector : Panama Canal, Costa Rica & Mexican Riviera Discovery
Starting in Colon, Panama Canal, Balboa / Fuerte Amador, Isla Partida, Golfo Dulce (Puerto Jimenez), Quepos, Puerto Caldera, Curu, Costa Rica, Playas del Coco, Puerto Chiapas, Huatulco, Puerto Vallarta
2026 Sails: Apr 13, More...

Cunard Line, Queen Elizabeth

20 Night - Miami to Seattle
Starting in Miami, FL, Cartagena CO, Colon, Panama, Transit the Panama Canal, Panama (Full Transit), Puntarenas, Costa Rica, Santa Cruz (for Huatulco), Mexico, Puerto Vallarta, Mexico, San Diego, CA, Seattle, WA
2026 Sails: Apr 14, More...

Cunard Line, Queen Elizabeth

Deal link -> Special

30 Night - Miami to Seattle
Starting in Miami, FL, Cartagena CO, Colon, Panama, Transit the Panama Canal, Panama (Full Transit), Puntarenas, Costa Rica, Santa Cruz (for Huatulco), Mexico, Puerto Vallarta, Mexico, San Diego, CA, Seattle, WA, Ketchikan, AK, Sitka, AK, Glacier Bay, AK, (Scenic Cruising), Juneau, AK, Skagway, AK, Tracy Arm Fjord, AK, (Scenic Cruising), Victoria CA, Canada, Seattle, WA
2026 Sails: Apr 14, More...

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