Panama Cruises
Cruises that visit Central America: Panama
Cruises that depart from Panama
See all River Cruises that visit Panama
Related areas: Azuero Peninsula : Balboa : Barro Colorado Island : Bocas del Toro : Cebaco Island : Chiriqui Lagoon : Coiba Island : Colon : Cristobal : Darien : Flamenco Island : Fort San Lorenzo : Fuerte Amador : Gatun : Gulf of Panama : Guna Yala : Isla Iguana : Lemon Cay : Pacheca Island : Panama Canal : Panama City : Parida Island : Pearl Islands : Playa Muerto : Portobelo : Punta Patino : San Blas Islands : San Jose Island
56 Night - World Cruise Liner - London (Dover) to Auckland
Starting in Dover UK (for London), England, Shetland Islands (Lerwick), Scotland, Reykjavik, Iceland, Grundarfjordur, Iceland, Isafjordur, Iceland, St Johns NF, Newfoundland, Corner Brook, Canada, Quebec City, Canada, Saguenay, Canada, Charlottetown, Canada, Sydney CA, Halifax, Canada, New York City (Manhattan or Brooklyn), New York, Miami, Florida, Cartagena CO, Panama Canal Full Transit New Locks, Manta, Ecuador, Lima (Callao), Peru, Pisco (General San Martin), Peru, Easter Island, Chile, Pitcairn Island (Scenic Cruising), Pitcairn Islands, Tahiti (Papeete), French Polynesia, Moorea, French Polynesia, Cross International Date Line, Auckland, New Zealand
2026 Sails: Jul 4, More...60 Night - World Cruise Liner - London (Dover) to Sydney
Starting in Dover UK (for London), England, Shetland Islands (Lerwick), Scotland, Reykjavik, Iceland, Grundarfjordur, Iceland, Isafjordur, Iceland, St Johns NF, Newfoundland, Corner Brook, Canada, Quebec City, Canada, Saguenay, Canada, Charlottetown, Canada, Sydney CA, Halifax, Canada, New York City (Manhattan or Brooklyn), New York, Miami, Florida, Cartagena CO, Panama Canal Full Transit New Locks, Manta, Ecuador, Lima (Callao), Peru, Pisco (General San Martin), Peru, Easter Island, Chile, Pitcairn Island (Scenic Cruising), Pitcairn Islands, Tahiti (Papeete), French Polynesia, Moorea, French Polynesia, Cross International Date Line, Auckland, New Zealand, Sydney AU
2026 Sails: Jul 4, More...62 Night - World Cruise Liner - London (Dover) to Brisbane
Starting in Dover UK (for London), England, Shetland Islands (Lerwick), Scotland, Reykjavik, Iceland, Grundarfjordur, Iceland, Isafjordur, Iceland, St Johns NF, Newfoundland, Corner Brook, Canada, Quebec City, Canada, Saguenay, Canada, Charlottetown, Canada, Sydney CA, Halifax, Canada, New York City (Manhattan or Brooklyn), New York, Miami, Florida, Cartagena CO, Panama Canal Full Transit New Locks, Manta, Ecuador, Lima (Callao), Peru, Pisco (General San Martin), Peru, Easter Island, Chile, Pitcairn Island (Scenic Cruising), Pitcairn Islands, Tahiti (Papeete), French Polynesia, Moorea, French Polynesia, Cross International Date Line, Auckland, New Zealand, Sydney AU, Brisbane, Australia
2026 Sails: Jul 4, More...38 Night - World Cruise Segment - New York to Sydney
Starting in New York City (Manhattan or Brooklyn), New York, Miami, Florida, Cartagena CO, Panama Canal Full Transit New Locks, Manta, Ecuador, Lima (Callao), Peru, Pisco (General San Martin), Peru, Easter Island, Chile, Pitcairn Island (Scenic Cruising), Pitcairn Islands, Tahiti (Papeete), French Polynesia, Moorea, French Polynesia, Cross International Date Line, Auckland, New Zealand, Sydney AU
2026 Sails: Jul 26, More...
39 Night - The Americas & Caribbean
Starting in Vancouver, Victoria CA, Canada, Astoria, Eureka, California, San Francisco, San Diego, Ensenada, Cabo San Lucas (Baja California Sur), Puerto Vallarta, Acajutla, Playa Flamingo, Puntarenas, Manta, Guayaquil, Fuerte Amador (Panama City), Panama Canal Transit, Cartagena CO, Santo Domingo, Punta Cana, San Juan, Marigot, St Martin, Roseau, Bridgetown, Castries, St Lucia, St Johns, Jost Van Dyke, British Virgin Islands, Samana, Grand Turk, New York
2026 Sails: Aug 17, More...32 Night - The Americas & Caribbean
Starting in San Diego, Ensenada, Cabo San Lucas (Baja California Sur), Puerto Vallarta, Acajutla, Playa Flamingo, Puntarenas, Manta, Guayaquil, Fuerte Amador (Panama City), Panama Canal Transit, Cartagena CO, Santo Domingo, Punta Cana, San Juan, Marigot, St Martin, Roseau, Bridgetown, Castries, St Lucia, St Johns, Jost Van Dyke, British Virgin Islands, Samana, Grand Turk, New York
2026 Sails: Aug 24, More...9 Night - The Americas & Caribbean
Starting in Guayaquil, Fuerte Amador (Panama City), Panama Canal Transit, Cartagena CO, Santo Domingo, Punta Cana, San Juan
2026 Sails: Sep 5, More...
7 Night - Southern Caribbean Cruise
Starting in Cartagena CO, Kralendijk, Bonaire, Oranjestad, Aruba, Willemstad AN, Curacao, Colon, Panama, Cartagena CO
2026 Sails: Sep 6, More...
40 Night - Seattle to Miami
Starting in Seattle, WA, Ketchikan, AK, Juneau, AK, Endicott Arm, AK, (Scenic Cruising), Victoria CA, Canada, Seattle, WA, Los Angeles, CA, Cabo San Lucas, Mexico, Puerto Quetzal, Guatemala, Fuerte Amador (tours to Panama City), Panama, Transit the Panama Canal, Panama (Full Transit), Willemstad AN, Curacao, Oranjestad, Aruba, Miami, FL, San Juan, Puerto Rico, St Johns AG, Antigua, Castries, St Lucia, Bridgetown, Barbados, Philipsburg, St Maarten, Road Town, Tortola, Miami, FL
2026 Sails: Sep 17, More...28 Night - Seattle to Miami
Starting in Seattle, WA, Ketchikan, AK, Juneau, AK, Endicott Arm, AK, (Scenic Cruising), Victoria CA, Canada, Seattle, WA, Los Angeles, CA, Cabo San Lucas, Mexico, Puerto Quetzal, Guatemala, Fuerte Amador (tours to Panama City), Panama, Transit the Panama Canal, Panama (Full Transit), Willemstad AN, Curacao, Oranjestad, Aruba, Miami, FL
2026 Sails: Sep 17, More...
Cruises that visit Central America: Panama
Cruises that depart from Panama
See all River Cruises that visit Panama
Click on a cruise ship itinerary that visits Panama (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just Panama), please visit: Cruise Search or try our Virtual Cruise Advisor™.
Related areas: Azuero Peninsula : Balboa : Barro Colorado Island : Bocas del Toro : Cebaco Island : Chiriqui Lagoon : Coiba Island : Colon : Cristobal : Darien : Flamenco Island : Fort San Lorenzo : Fuerte Amador : Gatun : Gulf of Panama : Guna Yala : Isla Iguana : Lemon Cay : Pacheca Island : Panama Canal : Panama City : Parida Island : Pearl Islands : Playa Muerto : Portobelo : Punta Patino : San Blas Islands : San Jose Island
56 Night - World Cruise Liner - London (Dover) to AucklandStarting in Dover UK (for London), England, Shetland Islands (Lerwick), Scotland, Reykjavik, Iceland, Grundarfjordur, Iceland, Isafjordur, Iceland, St Johns NF, Newfoundland, Corner Brook, Canada, Quebec City, Canada, Saguenay, Canada, Charlottetown, Canada, Sydney CA, Halifax, Canada, New York City (Manhattan or Brooklyn), New York, Miami, Florida, Cartagena CO, Panama Canal Full Transit New Locks, Manta, Ecuador, Lima (Callao), Peru, Pisco (General San Martin), Peru, Easter Island, Chile, Pitcairn Island (Scenic Cruising), Pitcairn Islands, Tahiti (Papeete), French Polynesia, Moorea, French Polynesia, Cross International Date Line, Auckland, New Zealand
2026 Sails: Jul 4, More...
60 Night - World Cruise Liner - London (Dover) to SydneyStarting in Dover UK (for London), England, Shetland Islands (Lerwick), Scotland, Reykjavik, Iceland, Grundarfjordur, Iceland, Isafjordur, Iceland, St Johns NF, Newfoundland, Corner Brook, Canada, Quebec City, Canada, Saguenay, Canada, Charlottetown, Canada, Sydney CA, Halifax, Canada, New York City (Manhattan or Brooklyn), New York, Miami, Florida, Cartagena CO, Panama Canal Full Transit New Locks, Manta, Ecuador, Lima (Callao), Peru, Pisco (General San Martin), Peru, Easter Island, Chile, Pitcairn Island (Scenic Cruising), Pitcairn Islands, Tahiti (Papeete), French Polynesia, Moorea, French Polynesia, Cross International Date Line, Auckland, New Zealand, Sydney AU
2026 Sails: Jul 4, More...
62 Night - World Cruise Liner - London (Dover) to BrisbaneStarting in Dover UK (for London), England, Shetland Islands (Lerwick), Scotland, Reykjavik, Iceland, Grundarfjordur, Iceland, Isafjordur, Iceland, St Johns NF, Newfoundland, Corner Brook, Canada, Quebec City, Canada, Saguenay, Canada, Charlottetown, Canada, Sydney CA, Halifax, Canada, New York City (Manhattan or Brooklyn), New York, Miami, Florida, Cartagena CO, Panama Canal Full Transit New Locks, Manta, Ecuador, Lima (Callao), Peru, Pisco (General San Martin), Peru, Easter Island, Chile, Pitcairn Island (Scenic Cruising), Pitcairn Islands, Tahiti (Papeete), French Polynesia, Moorea, French Polynesia, Cross International Date Line, Auckland, New Zealand, Sydney AU, Brisbane, Australia
2026 Sails: Jul 4, More...
38 Night - World Cruise Segment - New York to SydneyStarting in New York City (Manhattan or Brooklyn), New York, Miami, Florida, Cartagena CO, Panama Canal Full Transit New Locks, Manta, Ecuador, Lima (Callao), Peru, Pisco (General San Martin), Peru, Easter Island, Chile, Pitcairn Island (Scenic Cruising), Pitcairn Islands, Tahiti (Papeete), French Polynesia, Moorea, French Polynesia, Cross International Date Line, Auckland, New Zealand, Sydney AU
2026 Sails: Jul 26, More...
39 Night - The Americas & CaribbeanStarting in Vancouver, Victoria CA, Canada, Astoria, Eureka, California, San Francisco, San Diego, Ensenada, Cabo San Lucas (Baja California Sur), Puerto Vallarta, Acajutla, Playa Flamingo, Puntarenas, Manta, Guayaquil, Fuerte Amador (Panama City), Panama Canal Transit, Cartagena CO, Santo Domingo, Punta Cana, San Juan, Marigot, St Martin, Roseau, Bridgetown, Castries, St Lucia, St Johns, Jost Van Dyke, British Virgin Islands, Samana, Grand Turk, New York
2026 Sails: Aug 17, More...
32 Night - The Americas & CaribbeanStarting in San Diego, Ensenada, Cabo San Lucas (Baja California Sur), Puerto Vallarta, Acajutla, Playa Flamingo, Puntarenas, Manta, Guayaquil, Fuerte Amador (Panama City), Panama Canal Transit, Cartagena CO, Santo Domingo, Punta Cana, San Juan, Marigot, St Martin, Roseau, Bridgetown, Castries, St Lucia, St Johns, Jost Van Dyke, British Virgin Islands, Samana, Grand Turk, New York
2026 Sails: Aug 24, More...
9 Night - The Americas & CaribbeanStarting in Guayaquil, Fuerte Amador (Panama City), Panama Canal Transit, Cartagena CO, Santo Domingo, Punta Cana, San Juan
2026 Sails: Sep 5, More...
7 Night - Southern Caribbean CruiseStarting in Cartagena CO, Kralendijk, Bonaire, Oranjestad, Aruba, Willemstad AN, Curacao, Colon, Panama, Cartagena CO
2026 Sails: Sep 6, More...
40 Night - Seattle to MiamiStarting in Seattle, WA, Ketchikan, AK, Juneau, AK, Endicott Arm, AK, (Scenic Cruising), Victoria CA, Canada, Seattle, WA, Los Angeles, CA, Cabo San Lucas, Mexico, Puerto Quetzal, Guatemala, Fuerte Amador (tours to Panama City), Panama, Transit the Panama Canal, Panama (Full Transit), Willemstad AN, Curacao, Oranjestad, Aruba, Miami, FL, San Juan, Puerto Rico, St Johns AG, Antigua, Castries, St Lucia, Bridgetown, Barbados, Philipsburg, St Maarten, Road Town, Tortola, Miami, FL
2026 Sails: Sep 17, More...
28 Night - Seattle to MiamiStarting in Seattle, WA, Ketchikan, AK, Juneau, AK, Endicott Arm, AK, (Scenic Cruising), Victoria CA, Canada, Seattle, WA, Los Angeles, CA, Cabo San Lucas, Mexico, Puerto Quetzal, Guatemala, Fuerte Amador (tours to Panama City), Panama, Transit the Panama Canal, Panama (Full Transit), Willemstad AN, Curacao, Oranjestad, Aruba, Miami, FL
2026 Sails: Sep 17, More...
