Panama Cruises

Cruises that visit Central America: Panama

Cruises that depart from Panama

See all River Cruises that visit Panama

Click on a cruise ship itinerary that visits Panama (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just Panama), please visit: Cruise Search or try our Virtual Cruise Advisor™.

AmaWaterways Tours, AmaMagdalena Tours

10 Night - Wonders of Colombia with in Panama City Post Cruise
Starting in Cartagena CO, Colombia, Mahates, Calamar, Magangue, Mompox, Santa Barbara de Pinto, Sitionuevo, Barranquilla, Panama City
2026 Sails: Aug 29, Sep 12, Oct 10, Oct 24, Nov 21, Dec 5, 2027: May 22, More...

Celebrity Cruises, Celebrity Flora

7 Night - Galapagos Inner Loop Cruise
Starting in Baltra (Galapagos), Egas Port, Rabida (Galapagos), Elizabeth Bay (Isabela), Tagus Cove (Isabela), Sullivan Bay (Santiago), Bartolome Island, Las Bachas, Santa Cruz Island, Daphne Island, North Seymour Island, Puerto Baquerizo (Cristobal), Punta Pitt (San Cristobal), Puerto Ayora, Santa Cruz Island, Baltra (Galapagos)
2026 Sails: Aug 30, Sep 13, Oct 11, Dec 20, 2027: Jan 3, Jan 17, Jan 31, Feb 14, Mar 14, Mar 28, Apr 11, Apr 25, May 23, Jun 6, Jun 20, Jul 4, Jul 18, Aug 1, Aug 15, Aug 29, Sep 12, Sep 26, Oct 10, Oct 24, More...

Crystal Cruises, Crystal Symphony

9 Night - The Americas & Caribbean
Starting in Guayaquil, Fuerte Amador (Panama City), Panama Canal Transit, Cartagena CO, Santo Domingo, Punta Cana, San Juan
2026 Sails: Sep 5, More...

Royal Caribbean, Grandeur of the Seas

7 Night - Southern Caribbean Cruise
Starting in Cartagena CO, Kralendijk, Bonaire, Oranjestad, Aruba, Willemstad AN, Curacao, Colon, Panama, Cartagena CO
2026 Sails: Sep 6, More...

Cunard Line, Queen Elizabeth

40 Night - Seattle to Miami
Starting in Seattle, WA, Ketchikan, AK, Juneau, AK, Endicott Arm, AK, (Scenic Cruising), Victoria CA, Canada, Seattle, WA, Los Angeles, CA, Cabo San Lucas, Mexico, Puerto Quetzal, Guatemala, Fuerte Amador (tours to Panama City), Panama, Transit the Panama Canal, Panama (Full Transit), Willemstad AN, Curacao, Oranjestad, Aruba, Miami, FL, San Juan, Puerto Rico, St Johns AG, Antigua, Castries, St Lucia, Bridgetown, Barbados, Philipsburg, St Maarten, Road Town, Tortola, Miami, FL
2026 Sails: Sep 17, More...

Princess Cruises, Island Princess

16 Night - Panama Canal - Ocean to Ocean
Starting in Los Angeles, California, Puerto Vallarta, Mexico, Huatulco, Mexico, Puerto Chiapas, Mexico, Puntarenas, Costa Rica, Fuerte Amador, Panama (for Panama City), Panama Canal Full Transit Historic Locks, Aruba, Fort Lauderdale, Florida
2026 Sails: Sep 20, Dec 28, 2027: Mar 2, Apr 3, More...

MSC Cruises, MSC Poesia

26 Night - Msc Grand Voyages
Starting in Seattle, Washington, Ketchikan, Alaska, Sitka, Alaska, Endicott Arm and Dawes Glacier, Juneau, Alaska, Victoria CA, Canada, Seattle, Washington, Los Angeles, San Diego, Cabo San Lucas, Mexico, Puntarenas (San Jose), Costa Rica, Cruising Panama Canal, Colon, Panama, Cartagena CO, Miami, Florida
2026 Sails: Sep 21, More...

Princess Cruises, Coral Princess

22 Night - Panama Canal & Pacific Coast
Starting in Vancouver, Canada, San Francisco, California, San Diego, California, Los Angeles, California, Puerto Vallarta, Mexico, Huatulco, Mexico, Puerto Chiapas, Mexico, Puntarenas, Costa Rica, Fuerte Amador, Panama (for Panama City), Panama Canal Full Transit Historic Locks, Aruba, Fort Lauderdale, Florida
2026 Sails: Sep 23, More...

Cunard Line, Queen Elizabeth

21 Night - Seattle to Miami
Starting in Seattle, WA, Los Angeles, CA, Cabo San Lucas, Mexico, Puerto Quetzal, Guatemala, Fuerte Amador (tours to Panama City), Panama, Transit the Panama Canal, Panama (Full Transit), Willemstad AN, Curacao, Oranjestad, Aruba, Miami, FL
2026 Sails: Sep 24, More...

Carnival Cruise Lines, Carnival Miracle

16 Night - Journeys - Panama Canal
Starting in Seattle, Wa, Cabo San Lucas, Mexico, Puntarenas, Costa Rica, Panama Canal Transit, Cartagena CO, Galveston, Tx
2026 Sails: Sep 26, More...

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