Panama Cruises

Cruises that visit Central America: Panama

Cruises that depart from Panama

See all River Cruises that visit Panama

Click on a cruise ship itinerary that visits Panama (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just Panama), please visit: Cruise Search or try our Virtual Cruise Advisor™.

AmaWaterways Tours, AmaMagdalena Tours

13 Night - Magic of Colombia with in Medellin Pre Cruise and in Panama City Post Cruise
Starting in Medellin, Barranquilla, Medellin, San Felipe, Magangue, Mompox, Calamar, Manzini, Cartagena CO, Colombia, Panama City
2026 Sails: Apr 1, Apr 15, Apr 29, May 27, Jun 10, Jun 24, Jul 8, Aug 19, Sep 2, Sep 30, Oct 14, Oct 28, Nov 11, Nov 25, Dec 9, Dec 23, More...

AmaWaterways Tours, AmaMelodia Tours

10 Night - Magic of Colombia with Panama Post Cruise
Starting in Barranquilla, San Felipe, Magangue, Mompox, Calamar, Manzini, Cartagena CO, Colombia, Panama City
2026 Sails: Apr 1, Apr 15, Apr 29, May 13, May 27, Jun 10, Jul 22, Aug 5, Aug 19, Sep 2, Sep 16, Sep 30, Oct 28, Nov 11, Nov 25, Dec 9, More...

AmaWaterways Tours, AmaMelodia Tours

15 Night - Wonders of Colombia with in Medellin, in Cartagena Pre Cruise and in Panama City Post Cruise
Starting in Medellin, Cartagena CO, Colombia, Manzini, Calamar, Magangue, Mompox, San Felipe, Barranquilla, Panama City
2026 Sails: Apr 3, May 1, May 15, May 29, Jun 12, Aug 7, Aug 21, Sep 4, Oct 30, Nov 13, Nov 27, Dec 11, More...

AmaWaterways Tours, AmaMagdalena Tours

10 Night - Magic of Colombia with Panama Post Cruise
Starting in Barranquilla, San Felipe, Magangue, Mompox, Calamar, Manzini, Cartagena CO, Colombia, Panama City
2026 Sails: Apr 4, Apr 18, May 2, May 30, Jun 13, Jun 27, Jul 11, Aug 22, Sep 5, Oct 3, Oct 17, Oct 31, Nov 14, Nov 28, Dec 12, Dec 26, More...

Oceania Cruises, Oceania Insignia

10 Night - Classic Canal & Tropics
Starting in Panama City, Panama Canal Daylight Transit, Cartagena CO, Willemstad AN, Oranjestad, Montego Bay, George Town, Miami
2026 Sails: Apr 4, More...

Cunard Line, Queen Anne

25 Night - Los Angeles to Southampton
Starting in Los Angeles, CA, Puerto Quetzal, Guatemala, Transit the Panama Canal, Panama (Full Transit), Willemstad AN, Curacao, Oranjestad, Aruba, Miami, FL, Ponta Delgada, Azores, Portugal, Southampton, England, UK
2026 Sails: Apr 5, More...

Cunard Line, Queen Anne

14 Night - Los Angeles to Miami
Starting in Los Angeles, CA, Puerto Quetzal, Guatemala, Transit the Panama Canal, Panama (Full Transit), Willemstad AN, Curacao, Oranjestad, Aruba, Miami, FL
2026 Sails: Apr 5, More...

Disney Cruise Line, Disney Magic

14 Night - Westbound Panama Canal Cruise from Galveston Ending in San Diego
Starting in Galveston, Cozumel, Mexico, Cartagena ES, Panama Canal, Puerto Vallarta, Cabo San Lucas, San Diego
2026 Sails: Apr 5, More...

Holland America, Eurodam

19 Night - Panama Canal
Starting in Fort Lauderdale, Florida, Cartagena CO, Enter Panama Canal Cristobal, Cruising Panama Canal, Exit Panama Canal Balboa, Puntarenas (Puerto Caldera), Costa Rica, Acajutla, El Salvador, Puerto Quetzal, Guatemala, Puerto Vallarta, Mexico, Cabo San Lucas, Mexico, San Diego, California, Avalon, California, Vancouver, BC, CA
2026 Sails: Apr 5, More...

Holland America, Eurodam

15 Night - Panama Canal
Starting in Fort Lauderdale, Florida, Cartagena CO, Enter Panama Canal Cristobal, Cruising Panama Canal, Exit Panama Canal Balboa, Puntarenas (Puerto Caldera), Costa Rica, Acajutla, El Salvador, Puerto Quetzal, Guatemala, Puerto Vallarta, Mexico, Cabo San Lucas, Mexico, San Diego, California
2026 Sails: Apr 5, More...

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