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Panama Cruises

Cruises that visit Central America: Panama

Cruises that depart from Panama

Click on a cruise ship itinerary that visits Panama (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just Panama), please visit: Cruise Search or try our Virtual Cruise Advisor™.

Related areas: Balboa : Barro Colorado Island : Bocas del Toro : Cayos Limones : Cebaco Island : Chiriqui Lagoon : Coiba Island : Colon : Cristobal : Darien : Flamenco Island : Fort San Lorenzo : Fuerte Amador : Gatun : Gulf of Panama : Guna Yala : Isla Iguana : Lemon Cay : Pacheca Island : Panama Canal : Panama City : Parida Island : Pearl Islands : Playa Muerto : Portobelo : Punta Patino : San Blas Islands : San Jose Island

Panama
Cruise Specials

Holland America Line (HAL), HAL Rotterdam
HAL Rotterdam Cruise Ship21 Night - Southern Caribbean & Panama Canal Holiday
Starting in Fort Lauderdale, Florida, Willemstad AN, Curacao, Kralendijk, Bonaire, Oranjestad, Aruba, Half Moon Cay, Bahamas, Fort Lauderdale, Florida, Half Moon Cay, Bahamas, Willemstad AN, Curacao, Cartagena CO, Enter Panama Canal Cristobal, Cruising Panama Canal and Gatun Lake, Gatun Lake, Panama, Cruising Gatun Lake and Panama Canal, Exit Panama Canal Cristobal, Colon, Panama, Puerto Limon (San Jose), Costa Rica, Ocho Rios, Jamaica, Fort Lauderdale, Florida
2025 Sails: Dec 19, More...
PONANT, Le Dumont-D'Urville
Le Dumont-D'Urville Cruises7 Night - Central America Jewels & Panama Canal
Starting in Colon, San Blas Islands, Crossing the Panama Canal, Fuerte Amador, Flamenco Island, Playa Muerto, Darien National Park, Golfito, Puntarenas
2025 Sails: Dec 19, More...
Viking Ocean, Viking Sky
Viking Sky Cruises17 Night - Panama Canal & the Pacific Coast
Starting in Fort Lauderdale, Florida, Scenic Sailing Gulf of Mexico, Cozumel, Mexico, Sail the Caribbean Sea, Cartagena CO, Colon, Scenic Sailing Panama Canal, Sail the Pacific Ocean, Puntarenas (Puerto Caldera), Sail the Pacific Ocean, Acajutla, Sail the Pacific Ocean, Los Angeles, California
2025 Sails: Dec 19, More...
Oceania Cruises, Oceania Vista
Oceania Vista Cruises17 Night - Pacific & Island Holiday
Starting in Los Angeles, Cabo San Lucas, Puerto Vallarta, Manzanillo, Acapulco, Puerto Quetzal, Puntarenas, Panama Canal Daylight Transit, Cartagena CO, George Town, Miami
2025 Sails: Dec 20, More...
Oceania Cruises, Oceania Vista
Oceania Vista Cruises77 Night - Spanning the Americas
Starting in Los Angeles, Cabo San Lucas, Puerto Vallarta, Manzanillo, Acapulco, Puerto Quetzal, Puntarenas, Panama Canal Daylight Transit, Cartagena CO, George Town, Miami, Gustavia, Roseau, Bridgetown, Devils Island, Belem (Icoaraci), Fortaleza, Salvador, Buzios, Brazil, Rio De Janeiro, Ilha Grande, Brazil, Sao Paulo (Santos), Porto Belo, Rio Grande, Punta Del Este, Montevideo, Buenos Aires, Montevideo, Port Stanley, Falkland Islands, Ushuaia, Punta Arenas, Puerto Montt, Santiago De Chile (Valparaiso), Coquimbo, Iquique, Pisco / Nazca Lines, Lima / Machu Picchu (Callao), Salaverry, Manta, Puntarenas, Acajutla, Acapulco, Cabo San Lucas, Ensenada, San Diego
2025 Sails: Dec 20, More...
Star Clippers, Star Clipper
Star Clipper Cruise Ship7 Night - Costa Rica & Panama
Starting in Puerto Caldera, Costa Rica, Quepos, Costa Rica, Golfito, Costa Rica, Coiba National Park, Panama, Marine Park Golfo De Chiriqui / Parida Island, Panama, Islas Tortugas, Costa Rica, Puerto Caldera, Costa Rica
2025 Sails: Dec 20, 2027: Jan 2, More...
Windstar Cruises, Star Pride
Star Pride Cruises7 Night - Costa Rica & Panama Canal
Starting in Puerto Caldera, Quepos, Golfo Dulce (Puerto Jimenez), Isla Partida, Balboa / Fuerte Amador, Panama Canal, Colon
2025 Sails: Dec 20, More...
Lindblad Expeditions, National Geographic Quest
National Geographic Quest Cruises7 Night - Costa Rica and the Panama Canal
Starting in Panama City, Panama / Colon / Embark Ship, Gatun Lake / Panama Canal Transit, Gulf of Panama Islets, Coiba National Park, Panama, Golfo Dulce / Osa Peninsula, Corcovado National Park, Puerto Caldera / Disembark Ship / San Jose
2025 Sails: Dec 21, 2026: Jan 23, Feb 11, Mar 2, Mar 21, Dec 20, 2027: Jan 3, Feb 6, Feb 20, Mar 6, Mar 20, Dec 4, Dec 23, 2028: Jan 6, Feb 5, Feb 19, Mar 23, Apr 6, More...
Royal Caribbean International (RCL), RCL Serenade of the Seas
RCL Serenade of the Seas Cruise Ship7 Night - Southern Caribbean Holiday
Starting in Cartagena CO, Willemstad AN, Curacao, Oranjestad, Aruba, Colon, Panama, Cartagena CO
2025 Sails: Dec 21, More...
Celebrity Cruises, Celebrity Ascent
Celebrity Ascent Cruises11 Night - Panama Canal & Perfect Day Holiday
Starting in Fort Lauderdale, Florida, Cartagena CO, Panama Canal (Cruising), Colon, Panama, Oranjestad, Aruba, Willemstad AN, Curacao, Perfect Day Cococay, Bahamas, Fort Lauderdale, Florida
2025 Sails: Dec 22, More...

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Panama Cruises