United States Cruise Departures

Cruises that depart from North America: United States

Cruises that visit United States

See all River Cruises that depart from United States

Click on a cruise ship itinerary sailing from United States (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just United States), please visit: Cruise Search or try our Virtual Cruise Advisor™.

Departing from
United States
Cruise Specials

Royal Caribbean, Serenade of the Seas

4 Night - Catalina & Ensenada Cruise
Starting in San Diego, California, Catalina Island, California, Ensenada, Mexico, San Diego, California
2026 Sails: Oct 11, Nov 29, Dec 6, More...

Royal Caribbean, Star of the Seas

Deal link -> Special

7 Night - Western Caribbean & Perfect Day
Starting in Orlando (Port Canaveral), Fl, Perfect Day Cococay, Bahamas, Cozumel, Mexico, Roatan, Honduras, Puerto Costa Maya, Mexico, Orlando (Port Canaveral), Fl
2026 Sails: Oct 11, 2027: Apr 25, More...

American Cruise Lines, American Heritage

7 Night - Highlights of the Mississippi Cruise
Starting in New Orleans, La, Cruising the Historic Mississippi River, Oak Alley, LA, Baton Rouge, LA, Natchez / Vicksburg, MS, St Francisville, LA, New Orleans, La
2026 Sails: Oct 12, Nov 1, Nov 7, Nov 13, Nov 19, Nov 25, Dec 1, 2027: Mar 22, Mar 28, Apr 3, Apr 9, Apr 15, Apr 21, Apr 27, May 3, May 9, May 15, May 21, May 27, Jun 2, Jun 8, Jun 14, Jun 20, Nov 9, More...

Carnival Cruise Lines, Carnival Miracle

10 Night - Western Caribbean
Starting in Galveston, Tx, Grand Cayman, Cayman Islands, Montego Bay, Jamaica, Isla Tropicale, Roatan, Belize, Cozumel, Mexico, Galveston, Tx
2026 Sails: Oct 12, 2027: Apr 12, More...

Disney Cruise Line, Disney Dream

4 Night - Bahamian Cruise from Fort Lauderdale
Starting in Port Everglades, Disney Lookout Cay, Nassau, Port Everglades
2026 Sails: Oct 12, Oct 26, Nov 9, Nov 23, 2027: Jan 18, Feb 15, Mar 1, Mar 15, Mar 29, More...

Margaritaville at Sea, Margaritaville Paradise

3 Night - Grand Bahama Escape
Starting in Port of Palm Beach, Freeport, Grand Bahama, Port of Palm Beach
2026 Sails: Oct 12, Nov 6, Nov 20, Nov 27, Dec 11, Dec 18, More...

Royal Caribbean, Jewel of the Seas

4 Night - Key West & Perfect Day Cruise
Starting in Fort Lauderdale, Florida, Perfect Day Cococay, Bahamas, Nassau, Bahamas, Key West, Florida, Fort Lauderdale, Florida
2026 Sails: Oct 12, More...

Royal Caribbean, Ovation Of The Seas

4 Night - Catalina & Ensenada Cruise
Starting in Los Angeles, California, Catalina Island, California, Ensenada, Mexico, Los Angeles, California
2026 Sails: Oct 12, Oct 19, Oct 26, Nov 2, Nov 9, Nov 16, Nov 23, Nov 30, Dec 14, More...

Norwegian Cruise Line, Norwegian Bliss

16 Night - Repo - Panama Canal
Starting in Los Angeles, Ca, Cabo San Lucas, Mexico, Acapulco, Mexico, Puerto Quetzal, Guatemala, Puerto Caldera / Puntarenas, Costa Rica, Panama City, Panama, Transit Panama Canal / At Sea, Cartagena CO, Falmouth, Jamaica, Miami, Fl
2026 Sails: Oct 13, More...

Norwegian Cruise Line, Norwegian Bliss

19 Night - Repo - Panama Canal
Starting in Los Angeles, Ca, Cabo San Lucas, Mexico, Acapulco, Mexico, Puerto Quetzal, Guatemala, Puerto Caldera / Puntarenas, Costa Rica, Panama City, Panama, Transit Panama Canal / At Sea, Cartagena CO, Falmouth, Jamaica, Miami, Fl, New York City, Ny
2026 Sails: Oct 13, More...

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United States Cruise Departures