United States Cruise Departures

Cruises that depart from North America: United States

Cruises that visit United States

See all River Cruises that depart from United States

Click on a cruise ship itinerary sailing from United States (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just United States), please visit: Cruise Search or try our Virtual Cruise Advisor™.

Departing from
United States
Cruise Specials

American Cruise Lines, American West

8 Night - Columbia & Snake Rivers Cruise
Starting in Portland-OR, Cruising the Columbia River, Astoria, Or, Kalama, WA, The Dalles, OR, Cruising the Columbia River, Pendleton, OR / Richland, WA, Clarkston, WA
2026 Sails: May 3, May 17, May 31, Jun 14, Jun 28, Jul 12, Jul 26, Aug 9, Aug 23, Sep 6, Sep 20, Oct 4, More...

Carnival Cruise Lines, Carnival Horizon

6 Night - Western Caribbean
Starting in Miami, Fl, Celebration Key, the Bahamas, Montego Bay, Jamaica, Grand Cayman, Cayman Islands, Miami, Fl
2026 Sails: May 3, Jun 28, Jul 12, Jul 26, Aug 23, Sep 6, Sep 20, Oct 18, Nov 1, Nov 15, 2027: Jan 4, Jan 10, Feb 7, Feb 21, Mar 7, Apr 4, Apr 18, More...

Carnival Cruise Lines, Carnival Liberty

7 Night - Western Caribbean
Starting in New Orleans, La, Cozumel, Mexico, Belize, Mahogany Bay, Roatan, New Orleans, La
2026 Sails: May 3, More...

Carnival Cruise Lines, Carnival Venezia

7 Night - Eastern Caribbean
Starting in Port Canaveral (Orlando), Fl, Grand Turk, San Juan, Puerto Rico, St Thomas, US Virgin Islands, Port Canaveral (Orlando), Fl
2026 Sails: May 3, May 10, More...

Celebrity Cruises, Celebrity Beyond

7 Night - Grand Cayman, Mexico & Bahamas
Starting in Miami, Florida, George Town, Grand Cayman, Cozumel, Mexico, Puerto Costa Maya, Mexico, Bimini, Bahamas, Miami, Florida
2026 Sails: May 3, More...

Holland America, Noordam

7 Night - Alaska Explorer
Starting in Seattle, Washington, Puget Sound, Scenic cruising Stephens Passage, Juneau, Alaska, Scenic cruising Endicott Arm / Dawes Glacier, Sitka, Alaska, Ketchikan, Alaska, Victoria CA, Canada, Seattle, Washington
2026 Sails: May 3, More...

Holland America, Volendam

14 Night - Grand World Voyage
Starting in San Diego, California, Manzanillo, Mexico, Puerto Chiapas, Mexico, Acajutla, El Salvador, Fuerte Amador, Panama, Enter Panama Canal Balboa, Cruising Panama Canal, Exit Panama Canal Cristobal, Cartagena CO, Fort Lauderdale, Florida
2026 Sails: May 3, More...

Margaritaville at Sea, Margaritaville Paradise

4 Night - Cozumel Express
Starting in Port of Palm Beach, Cozumel, Mexico, Port of Palm Beach
2026 Sails: May 3, More...

MSC Cruises, MSC Seashore

11 Night - Caribbean and Antilles
Starting in Port Canaveral (Orlando), Florida, Nassau, Bahamas, Cozumel, Mexico, Costa Maya, Mexico, Ocean Cay Msc Marine Reserve, Bahamas, Port Canaveral (Orlando), Florida, Ocean Cay Msc Marine Reserve, Bahamas, Nassau, Bahamas, Port Canaveral (Orlando), Florida
2026 Sails: May 3, May 17, Jul 12, Jul 26, Aug 9, Aug 23, Sep 6, Sep 20, Oct 4, More...

MSC Cruises, MSC Seashore

7 Night - Caribbean and Antilles
Starting in Port Canaveral (Orlando), Florida, Nassau, Bahamas, Cozumel, Mexico, Costa Maya, Mexico, Ocean Cay Msc Marine Reserve, Bahamas, Port Canaveral (Orlando), Florida
2026 Sails: May 3, More...

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United States Cruise Departures