United States Cruise Departures

Cruises that depart from North America: United States

Cruises that visit United States

See all River Cruises that depart from United States

Click on a cruise ship itinerary sailing from United States (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just United States), please visit: Cruise Search or try our Virtual Cruise Advisor™.

Departing from
United States
Cruise Specials

MSC Cruises, MSC Poesia

19 Night - Msc Grand Voyages
Starting in Seattle, Washington, Los Angeles, San Diego, Cabo San Lucas, Mexico, Puntarenas (San Jose), Costa Rica, Cruising Panama Canal, Colon, Panama, Cartagena CO, Miami, Florida
2026 Sails: Sep 28, More...

MSC Cruises, MSC Poesia

24 Night - Msc Grand Voyages
Starting in Seattle, Washington, Los Angeles, San Diego, Cabo San Lucas, Mexico, Puntarenas (San Jose), Costa Rica, Cruising Panama Canal, Colon, Panama, Cartagena CO, Miami, Florida, George Town, Cayman Islands, Ocho Rios, Jamaica, Miami, Florida
2026 Sails: Sep 28, More...

Regent Seven Seas, Seven Seas Splendor

11 Night - Magnifique L'automne
Starting in Boston, Portland ME, Saint John NB (Bay of Fundy), Halifax, Sydney NS, Charlottetown, Cruising the Gulf of St Lawrence, Gaspesie, Sept-Iles, Saguenay, Quebec City, Montreal
2026 Sails: Sep 28, More...

Royal Caribbean, Ovation Of The Seas

3 Night - Ensenada Cruise
Starting in Los Angeles, California, Ensenada, Mexico, Los Angeles, California
2026 Sails: Sep 28, Oct 1, Oct 16, Nov 6, Nov 20, More...

Carnival Cruise Lines, Carnival Venezia

7 Night - Bermuda
Starting in Manhattan, New York City, Bermuda, Manhattan, New York City
2026 Sails: Sep 29, More...

Celebrity Cruises, Celebrity Solstice

18 Night - Treasures of Tahiti & Fiji
Starting in Honolulu, Oahu, Hawaii, Papeete, Tahiti, Moorea, French Polynesia, Raiatea, French Polynesia, International Dateline, Suva, Fiji, Lautoka, Fiji, Bay of Islands, New Zealand
2026 Sails: Sep 29, More...

Princess Cruises, Coral Princess

16 Night - Panama Canal - Ocean to Ocean
Starting in Los Angeles, California, Puerto Vallarta, Mexico, Huatulco, Mexico, Puerto Chiapas, Mexico, Puntarenas, Costa Rica, Fuerte Amador, Panama (for Panama City), Panama Canal Full Transit Historic Locks, Aruba, Fort Lauderdale, Florida
2026 Sails: Sep 29, More...

Princess Cruises, Emerald Princess

16 Night - Hawaiian Islands
Starting in Los Angeles, California, Honolulu, Hawaii, Kauai (Nawiliwili), Hawaii, Hilo, Hawaii, Kahului, Hawaii, Ensenada, Mexico, Los Angeles, California
2026 Sails: Sep 30, More...

Regent Seven Seas, Seven Seas Explorer

20 Night - Pacific Passage Adventure
Starting in Seattle, Cruising the Inside Passage, Ketchikan, Juneau, Cruising Hubbard Glacier, Anchorage (Whittier), Cruising the Pacific Ocean, Cross the International Date Line, Cruising the Pacific Ocean, Kushiro, Hakodate, Muroran, Miyako, Hitachinaka, Tokyo
2026 Sails: Sep 30, More...

American Cruise Lines, American Independence

8 Night - Chesapeake Bay Cruise
Starting in Baltimore, MD, Day of Cruising Chesapeake Bay, Yorktown, VA / Williamsburg, VA, Cruising the Chesapeake Bay, St Michaels, MD, Annapolis, MD, Baltimore, MD
2026 Sails: Oct 1, Oct 8, Oct 29, 2027: Sep 17, Sep 24, Oct 15, Oct 22, 2028: Apr 30, May 7, Oct 23, More...

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United States Cruise Departures