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United States Cruise Departures

Cruises that depart from North America: United States

Cruises that visit United States

See all River Cruises that depart from United States

Click on a cruise ship itinerary sailing from United States (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just United States), please visit: Cruise Search or try our Virtual Cruise Advisor™.

Related areas: Alabama : Alaska : California : Florida : Hawaii : Illinois : Kentucky : Louisiana : Maine : Maryland : Massachusetts : Minnesota : Missouri : New Jersey : New York : Oklahoma : Oregon : Pennsylvania : Rhode Island : South Carolina : Tennessee : Texas : Virginia : Washington : Washington DC : Wisconsin : Wyoming

Departing from
United States
Cruise Specials

Disney Cruise Line, Disney Dream
Disney Dream7 Night - Very Merrytime Eastern Caribbean Cruise from Fort Lauderdale
Starting in Port Everglades, Disney Lookout Cay, San Juan, Puerto Plata, Dominican Republic, Castaway Cay, Port Everglades
2026 Sails: Oct 2, Nov 13, More...
Disney Cruise Line, Disney Wish
Disney Wish3 Night - Bahamian Cruise from Port Canaveral
Starting in Port Canaveral, Nassau, Castaway Cay, Port Canaveral
2026 Sails: Oct 2, Oct 9, Oct 16, Oct 23, Oct 30, Nov 6, Nov 13, Nov 20, Nov 27, Dec 4, Dec 11, Dec 18, Dec 28, 2027: Jan 8, Jan 15, Jan 22, Jan 29, Feb 5, Feb 12, Feb 19, Feb 26, Mar 5, Mar 12, Mar 19, More...
Holland America, Nieuw Amsterdam
Nieuw Amsterdam16 Night - Panama Canal
Starting in San Diego, California, Puerto Vallarta, Mexico, Huatulco, Mexico, Puerto Chiapas, Mexico, Puerto Quetzal, Guatemala, Acajutla, El Salvador, Enter Panama Canal Balboa, Cruising Panama Canal, Exit Panama Canal Cristobal, Cartagena CO, RelaxAway, Half Moon Cay, Bahamas, Fort Lauderdale, Florida
2026 Sails: Oct 2, More...
MSC Cruises, MSC Poesia
MSC Poesia15 Night - Msc Grand Voyages
Starting in Los Angeles, San Diego, Cabo San Lucas, Mexico, Puntarenas (San Jose), Costa Rica, Cruising Panama Canal, Colon, Panama, Cartagena CO, Miami, Florida
2026 Sails: Oct 2, More...
Royal Caribbean, Adventure of the Seas
Adventure of the Seas8 Night - Southern Caribbean & Perfect Day
Starting in Orlando (Port Canaveral), Fl, Perfect Day Cococay, Bahamas, Oranjestad, Aruba, Willemstad AN, Curacao, Orlando (Port Canaveral), Fl
2026 Sails: Oct 2, More...
Royal Caribbean, Jewel of the Seas
Jewel of the Seas3 Night - Bahamas & Perfect Day Cruise
Starting in Fort Lauderdale, Florida, Nassau, Bahamas, Perfect Day Cococay, Bahamas, Fort Lauderdale, Florida
2026 Sails: Oct 2, 2027: Aug 27, More...
Royal Caribbean, Navigator of the Seas
Navigator of the Seas15 Night - Los Angeles to Tokyo Cruise
Starting in Los Angeles, California, International Dateline, Hakodate, Japan, Sapporo (Muroran), Japan, Mount Fuji (Shimizu), Japan
2026 Sails: Oct 2, More...
Royal Caribbean, Serenade of the Seas
Serenade of the Seas2 Night - Ensenada Cruise
Starting in San Diego, California, Ensenada, Mexico, San Diego, California
2026 Sails: Oct 2, More...
Viking Ocean, Viking Octantis
Viking Octantis7 Night - Niagara & the Great Lakes
Starting in Milwaukee, Wisconsin, Mackinac Island, Michigan, Alpena, Michigan, Detroit, Michigan, Point Pelee, Ontario, Niagara Falls (Port Colborne), Ontario, Welland Canal, Toronto, Ontario
2026 Sails: Oct 2, 2028: Jun 3, 2029: May 29, More...
Virgin Voyages, Valiant Lady
Valiant Lady5 Night - Stuff at Sea
Starting in New York City, New York, Royal Naval Dockyard, Bermuda, New York City, New York
2026 Sails: Oct 2, More...

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United States Cruise Departures