United States Cruise Departures

Cruises that depart from North America: United States

Cruises that visit United States

See all River Cruises that depart from United States

Click on a cruise ship itinerary sailing from United States (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just United States), please visit: Cruise Search or try our Virtual Cruise Advisor™.

Departing from
United States
Cruise Specials

Disney Cruise Line, Disney Treasure

7 Night - Eastern Caribbean Cruise from Port Canaveral
Starting in Port Canaveral, St Thomas, US Virgin Islands, Tortola, Castaway Cay, Port Canaveral
2026 Sails: Apr 25, More...

Holland America, Eurodam

Deal link -> Special

7 Night - Alaska Explorer
Starting in Seattle, Washington, Puget Sound, Scenic cruising Stephens Passage, Juneau, Alaska, Glacier Bay, Icy Strait Point, Alaska, Sitka, Alaska, Ketchikan, Alaska, Victoria CA, Canada, Seattle, Washington
2026 Sails: Apr 25, May 9, May 30, Jun 6, Jun 13, Jun 20, Jun 27, Jul 4, Jul 11, Jul 18, Jul 25, Aug 1, Aug 8, Aug 22, Aug 29, Sep 12, Sep 19, Sep 26, More...

Holland America, Zaandam

11 Night - Mexican Riviera & Pacific Coast
Starting in San Diego, California, Cabo San Lucas, Mexico, Mazatlan, Mexico, Puerto Vallarta, Mexico, San Diego, California, Victoria CA, Canada, Vancouver, BC, CA
2026 Sails: Apr 25, More...

Holland America, Zaandam

7 Night - Mexican Riviera
Starting in San Diego, California, Cabo San Lucas, Mexico, Mazatlan, Mexico, Puerto Vallarta, Mexico, San Diego, California
2026 Sails: Apr 25, More...

MSC Cruises, MSC World America

7 Night - Caribbean and Antilles
Starting in Miami, Florida, Isla De Roatan, Honduras, Costa Maya, Mexico, Cozumel, Mexico, Ocean Cay Msc Marine Reserve, Bahamas, Miami, Florida
2026 Sails: Apr 25, May 9, Jun 6, Jun 20, Jul 4, Jul 18, Aug 1, Aug 15, Aug 29, Sep 12, Oct 10, Oct 24, Nov 21, Dec 5, Dec 19, 2027: Jan 2, Jan 16, Jan 30, Feb 13, Mar 13, Mar 27, More...

MSC Cruises, MSC World America

14 Night - Caribbean and Antilles
Starting in Miami, Florida, Isla De Roatan, Honduras, Costa Maya, Mexico, Cozumel, Mexico, Ocean Cay Msc Marine Reserve, Bahamas, Miami, Florida, Puerto Plata, Dominican Republic, San Juan, Puerto Rico, Ocean Cay Msc Marine Reserve, Bahamas, Miami, Florida
2026 Sails: Apr 25, Sep 12, Sep 26, More...

Norwegian Cruise Line, Norwegian Aqua

7 Night - Bermuda - New York
Starting in New York City, Ny, Royal Naval Dockyard, Bermuda, New York City, Ny
2026 Sails: Apr 25, More...

Norwegian Cruise Line, Norwegian Bliss

7 Night - Alaska - Seattle
Starting in Seattle, Wa, Sitka, Ak, Juneau, Ak, Endicott Arm / Dawes Glacier, Icy Strait Point, Ak, Ketchikan (Ward Cove), Ak, Victoria CA, Canada, Seattle, Wa
2026 Sails: Apr 25, May 2, May 9, May 16, May 23, May 30, Jun 6, Jun 13, Jun 20, Jun 27, Jul 4, Jul 11, Jul 18, Jul 25, Aug 1, Aug 8, Aug 15, Aug 22, Aug 29, Sep 5, More...

Norwegian Cruise Line, Norwegian Joy

15 Night - Panama Canal - Miami
Starting in Miami, Fl, Cartagena CO, Colon, Panama, Transit Panama Canal / At Sea, Puerto Caldera / Puntarenas, Costa Rica, Puerto Quetzal, Guatemala, Puerto Vallarta, Mexico, Cabo San Lucas, Mexico, Los Angeles, Ca
2026 Sails: Apr 25, More...

Norwegian Cruise Line, Norwegian Joy

18 Night - Panama Canal - Miami
Starting in Miami, Fl, Cartagena CO, Colon, Panama, Transit Panama Canal / At Sea, Puerto Caldera / Puntarenas, Costa Rica, Puerto Quetzal, Guatemala, Puerto Vallarta, Mexico, Cabo San Lucas, Mexico, Los Angeles, Ca, Seattle, Wa
2026 Sails: Apr 25, More...

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United States Cruise Departures