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Italy Cruise Departures

Cruises that depart from Mediterranean: Italy

Cruises that visit Italy

See all River Cruises that depart from Italy

Click on a cruise ship itinerary sailing from Italy (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just Italy), please visit: Cruise Search or try our Virtual Cruise Advisor™.

Related areas: Ancona : Bari : Brindisi : Cagliari : Catania : Cernobbio : Civitavecchia : Fusina : Genoa : La Spezia : Lake Como : Livorno : Marghera : Messina : Milan : Naples : Olbia : Palermo : Perugia : Ravenna : Rome : Savona : Taormina : Taranto : Trieste : Venice

Departing from
Italy
Cruise Specials

Seabourn, Seabourn Quest
Seabourn Quest9 Night - Jewels of Andalusia & the Balearic Islands
Starting in Civitavecchia (Rome), Italy, Ajaccio, Corsica, France, Alghero, Italy, Mahon, Menorca, Spain, Ibiza, Spain, Cartagena ES, Motril (Granada), Spain, Ceuta, Spanish Morocco, Spain, Lisbon, Portugal
2026 Sails: Nov 1, More...
Celebrity Cruises, Celebrity Constellation
Celebrity Constellation15 Night - Spain & Morocco Transatlantic
Starting in Rome (Civitavecchia), Italy, Valencia, Spain, Cartagena ES, Malaga, Spain, Tangier, Morocco, Philipsburg, St Maarten, San Juan, Puerto Rico
2026 Sails: Nov 2, More...
Costa Cruise Lines, Costa Diadema
Costa Diadema8 Night - Western Mediterranean from Savona to Las Palmas
Starting in Savona, Barcelona, Malaga, Cadiz, Lisbon, Las Palmas (Gran Canaria)
2026 Sails: Nov 2, More...
Costa Cruise Lines, Costa Diadema
Costa Diadema9 Night - Western Mediterranean from Savona to Santa Cruz de Tenerife
Starting in Savona, Barcelona, Malaga, Cadiz, Lisbon, Las Palmas (Gran Canaria), Santa Cruz de Tenerife
2026 Sails: Nov 2, More...
Costa Cruise Lines, Costa Diadema
Costa Diadema23 Night - Transatlantic from Savona to Itajai
Starting in Savona, Barcelona, Malaga, Cadiz, Lisbon, Las Palmas (Gran Canaria), Santa Cruz de Tenerife, Mindelo (Sao Vicente), Maceio, Salvador Bahia, Rio De Janeiro, Santos (Sao Paulo), Itajai
2026 Sails: Nov 2, More...
Costa Cruise Lines, Costa Diadema
Costa Diadema6 Night - Western Mediterranean from Savona to Lisbon
Starting in Savona, Barcelona, Malaga, Cadiz, Lisbon
2026 Sails: Nov 2, More...
Costa Cruise Lines, Costa Diadema
Costa Diadema21 Night - Transatlantic from Savona
Starting in Savona, Barcelona, Malaga, Cadiz, Lisbon, Las Palmas (Gran Canaria), Santa Cruz de Tenerife, Mindelo (Sao Vicente), Maceio, Salvador Bahia, Rio De Janeiro, Santos (Sao Paulo)
2026 Sails: Nov 2, More...
Costa Cruise Lines, Costa Diadema
Costa Diadema20 Night - Transatlantic from Savona
Starting in Savona, Barcelona, Malaga, Cadiz, Lisbon, Las Palmas (Gran Canaria), Santa Cruz de Tenerife, Mindelo (Sao Vicente), Maceio, Salvador Bahia, Rio De Janeiro
2026 Sails: Nov 2, More...
MSC Cruises, MSC Sinfonia
MSC Sinfonia7 Night - Mediterranean
Starting in Genoa (Portofino), Italy, Livorno (Florence), Italy, Valencia, Spain, Palma De Mallorca (Balearic Islands), Spain, Barcelona, Spain, Marseille (Provence), France, Genoa (Portofino), Italy
2026 Sails: Nov 3, Nov 17, More...
MSC Cruises, MSC World Europa
MSC World Europa7 Night - Mediterranean
Starting in Messina (Taormina), Italy, La Valletta, Malta, Barcelona, Spain, Marseille (Provence), France, Genoa (Portofino), Italy, Civitavecchia (Rome), Italy, Messina (Taormina), Italy
2026 Sails: Nov 3, More...

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Italy Cruise Departures