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Palermo Cruise Departures

Cruises that depart from Mediterranean: Italy: Palermo

Cruises that visit Palermo

Click on a cruise ship itinerary sailing from Palermo (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just Palermo), please visit: Cruise Search or try our Virtual Cruise Advisor™.

Palermo
Shore Excursions

MSC Cruises, MSC Splendida
MSC Splendida Cruise Ship7 Night - Mediterranean
Starting in Palermo (Monreale), Italy, La Goulette, Tunisia, Barcelona, Spain, Marseille (Provence), France, Genoa (Portofino), Italy, Naples (Pompeii), Italy, Palermo (Monreale), Italy
2025 Sails: Dec 10, Dec 17, Dec 24, Dec 31, 2026: Feb 11, Feb 18, Feb 25, Mar 4, Mar 11, Mar 18, Mar 25, Apr 1, Apr 8, Apr 15, More...
Costa Cruise Lines, Costa Smeralda
Costa Smeralda Cruises7 Night - Western Mediterranean from Palermo
Starting in Palermo, Civitavecchia, Savona, Marseille, Barcelona, La Goulette, Palermo
2025 Sails: Dec 18, Dec 25, 2026: Jan 1, Jan 8, Jan 15, More...
MSC Cruises, MSC Splendida
MSC Splendida Cruise Ship3 Night - Mediterranean
Starting in Palermo (Monreale), Italy, La Goulette, Tunisia, Barcelona, Spain
2026 Sails: Jan 7, More...
Costa Cruise Lines, Costa Toscana
Costa Toscana Cruises12 Night - Western Mediterranean Roundtrip from Palermo
Starting in Palermo, Napoli, Civitavecchia, Savona, Marseille, Barcelona, Alicante, Malaga, Tangier, La Goulette, Palermo
2026 Sails: Jan 11, More...
Costa Cruise Lines, Costa Smeralda
Costa Smeralda Cruises7 Night - Western Mediterranean from Palermo
Starting in Palermo, Civitavecchia, Savona, Marseille, Barcelona, La Goulette, Palermo
2026 Sails: Jan 22, More...
Costa Cruise Lines, Costa Toscana
Costa Toscana Cruises5 Night - Western Mediterranean from Palermo
Starting in Palermo, Civitavecchia, Savona, Marseille, Barcelona, Marseille
2026 Sails: Jan 23, More...
Costa Cruise Lines, Costa Toscana
Costa Toscana Cruises3 Night - Western Mediterranean from Palermo
Starting in Palermo, Civitavecchia, Savona, Marseille
2026 Sails: Jan 23, More...
Costa Cruise Lines, Costa Smeralda
Costa Smeralda Cruises7 Night - Western Mediterranean from Palermo
Starting in Palermo, Civitavecchia, Savona, Marseille, Barcelona, La Goulette, Palermo
2026 Sails: Jan 29, Feb 5, Feb 12, Feb 19, Feb 26, Mar 5, More...
Costa Cruise Lines, Costa Smeralda
Costa Smeralda Cruises7 Night - Western Mediterranean from Palermo
Starting in Palermo, Civitavecchia, Savona, Marseille, Barcelona, La Goulette, Palermo
2026 Sails: Mar 12, Mar 19, Mar 26, Apr 2, More...
Costa Cruise Lines, Costa Smeralda
Costa Smeralda Cruises7 Night - Western Mediterranean Roundtrip from Palermo
Starting in Palermo, Civitavecchia, Savona, Marseille, Barcelona, La Goulette, Palermo
2026 Sails: Apr 9, Apr 16, Apr 23, Apr 30, May 7, More...

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Palermo Cruise Departures