Italy Cruise Departures

Cruises that depart from Mediterranean: Italy

Cruises that visit Italy

See all River Cruises that depart from Italy

Click on a cruise ship itinerary sailing from Italy (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just Italy), please visit: Cruise Search or try our Virtual Cruise Advisor™.

Related areas: Ancona : Bari : Brindisi : Cagliari : Catania : Cernobbio : Civitavecchia : Fusina : Genoa : La Spezia : Lake Como : Lecce : Livorno : Marghera : Messina : Milan : Naples : Napoli : Olbia : Palermo : Perugia : Ravenna : Rome : Savona : Taormina : Taranto : Trieste : Venice

Holland America, Oosterdam

10 Night - Adriatic Allure : Croatia, Greek Isles & Istanbul
Starting in Trieste (Venice), Italy, Rijeka, Croatia, Split, Croatia, Thira (Santorini), Greece, Bodrum, Turkey, Kusadasi (Ephesus), Turkey, Istanbul, Turkey, Cruising the Dardanelles, Piraeus (Athens), Greece
2026 Sails: Sep 23, More...

Holland America, Oosterdam

21 Night - Croatia, Greece & Istanbul Collectors' Voyage
Starting in Trieste (Venice), Italy, Rijeka, Croatia, Split, Croatia, Thira (Santorini), Greece, Bodrum, Turkey, Kusadasi (Ephesus), Turkey, Istanbul, Turkey, Cruising the Dardanelles, Piraeus (Athens), Greece, Nafplion, Greece, Istanbul, Turkey, Kusadasi (Ephesus), Turkey, Thira (Santorini), Greece, Rhodes, Greece, Souda (Chania), Greece, Piraeus (Athens), Greece
2026 Sails: Sep 23, More...

Azamara Cruises, Azamara Quest

9 Night - Croatia & Montenegro Cruise : Zadar, Dubrovnik & Kotor
Starting in Venice (Fusina), Zadar, Sibenik, Korcula, Dubrovnik, Croatia, Kotor, Corfu, Chania, Crete, Athens (Piraeus)
2026 Sails: Sep 24, More...

Costa Cruise Lines, Costa Smeralda

7 Night - Western Mediterranean Roundtrip from Palermo
Starting in Palermo (Sicily), Civitavecchia / Rome, Savona, Italy, Marseille, France, Barcelona, Spain, Balearic sea darkest spot, Ibiza, Spain, Palermo (Sicily)
2026 Sails: Sep 24, More...

Norwegian Line Tours, Norwegian Gem Tours

10 Night - Pre Venice Cruisetour
Starting in At Hotel, Venice (Ravenna), Italy, Dubrovnik, Croatia, Kotor, Montenegro, Corfu, Greece, Olympia / Katakolon, Greece, Messina, Italy, Amalfi Coast (Salerno), Italy, Civitavecchia Rome, Italy
2026 Sails: Sep 24, More...

Viking Ocean, Viking Star

9 Night - Empires of the Mediterranean
Starting in Venice (Chioggia), Koper, Zadar, Dubrovnik, Croatia, Kotor, Corfu (Kerkyra), Katakolon (Olympia), Santorini (Thira), Athens (Piraeus)
2026 Sails: Sep 24, More...

Norwegian Line Tours, Norwegian Epic Tours

9 Night - Rome & Etruria Pre Cruisetour
Starting in At Hotel, Civitavecchia Rome, Italy, Amalfi Coast (Salerno), Italy, Catania, Italy, Livorno / Florence / Pisa, Italy, Nice / Monaco (Villefranche), France, Provence, Marseille, France, Barcelona, Spain
2026 Sails: Sep 25, Oct 9, More...

Costa Cruise Lines, Costa Deliziosa

7 Night - Eastern Mediterranean from Marghera
Starting in Marghera, Bari, Corfu, Zakynthos, Argostoli / Cephalonia, Dubrovnik, Croatia, Split, Trieste
2026 Sails: Sep 26, More...

MSC Cruises, MSC Sinfonia

7 Night - Mediterranean
Starting in Bari, Italy, Santorini, Greece, Piraeus (Athens), Greece, Katakolon (Olympia), Greece, Cephalonia / Argostoli, Greece, Corfu, Greece, Bari, Italy
2026 Sails: Sep 26, More...

Princess Cruises, Sun Princess

14 Night - Mediterranean with Greece, Turkey, & Adriatic
Starting in Civitavecchia (for Rome), Italy, Naples, Italy (for Capri and Pompeii), Crete (Chania), Greece, Kusadasi, Turkey (for Ephesus), Mykonos, Greece, Athens (Piraeus), Greece, Montenegro, Corfu, Greece, Sicily (Messina), Italy, Naples, Italy (for Capri and Pompeii), Barcelona, Spain
2026 Sails: Sep 26, Oct 17, More...

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