Italy Cruise Departures

Cruises that depart from Mediterranean: Italy

Cruises that visit Italy

See all River Cruises that depart from Italy

Click on a cruise ship itinerary sailing from Italy (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just Italy), please visit: Cruise Search or try our Virtual Cruise Advisor™.

Related areas: Ancona : Bari : Brindisi : Cagliari : Catania : Cernobbio : Civitavecchia : Fusina : Genoa : La Spezia : Lake Como : Livorno : Marghera : Messina : Milan : Naples : Olbia : Palermo : Perugia : Ravenna : Rome : Savona : Taormina : Taranto : Trieste : Venice

Viking Ocean, Viking Neptune

7 Night - Italian Sojourn
Starting in Venice (Fusina), Sibenik, Bari, Crotone, Sicily (Messina), Naples, Rome (Civitavecchia)
2026 Sails: Nov 3, More...

Viking Ocean, Viking Vela

Deal link -> Special

7 Night - Journey to Antiquities
Starting in Rome (Civitavecchia), Naples, Sicily (Messina), Sail the Ionian Sea, Crete (Souda Bay), Ephesus (Kusadasi), Athens (Piraeus)
2026 Sails: Nov 3, 2028: Jan 11, More...

Costa Cruise Lines, Costa Smeralda

5 Night - Mediterranean from Cagliari to Barcelona
Starting in Cagliari, Palermo, Civitavecchia (Rome), Savona, Marseille, Barcelona
2026 Sails: Nov 4, More...

MSC Cruises, MSC Lirica

10 Night - Mediterranean
Starting in Venice / Marghera, Italy, Katakolon (Olympia), Greece, Heraklion (Crete), Greece, Rhodes (Lindos), Greece, Limassol, Cyprus, Port Said, Egypt, Alexandria EG, Egypt, Split, Croatia
2026 Sails: Nov 4, More...

Viking Ocean, Viking Jupiter

Deal link -> Special

7 Night - Iconic Western Mediterranean
Starting in Rome (Civitavecchia), Florence / Pisa (Livorno), Monte Carlo, Marseille, Sete, Barcelona
2026 Sails: Nov 4, More...

Viking Ocean, Viking Sky

14 Night - Mediterranean & Italian Sojourn
Starting in Venice (Chioggia), Sibenik, Bari, Crotone, Sicily (Catania), Naples, Rome (Civitavecchia), Florence / Pisa (Livorno), Monte Carlo, Marseille, Sete, Barcelona
2026 Sails: Nov 4, More...

Viking Ocean, Viking Sky

Deal link -> Special

7 Night - Italian Sojourn
Starting in Venice (Chioggia), Sibenik, Bari, Crotone, Sicily (Catania), Naples, Rome (Civitavecchia)
2026 Sails: Nov 4, More...

Costa Cruise Lines, Costa Fascinosa

10 Night - Western Mediterranean from Savona
Starting in Savona, Barcelona, Gibraltar, Tangier, Casablanca, Cadiz, Malaga, Marseille, Savona
2026 Sails: Nov 5, More...

Costa Cruise Lines, Costa Toscana

7 Night - Western Mediterranean from Civitavecchia
Starting in Civitavecchia (Rome), Genoa (Portofino), Marseille, Barcelona, Palma De Mallorca, Naples, Civitavecchia (Rome)
2026 Sails: Nov 5, Nov 12, More...

Oceania Cruises, Oceania Sirena

7 Night - Ancient Sites & Cities
Starting in Rome (Civitavecchia), Naples / Pompeii, Messina (Sicily), Valletta, Athens (Piraeus), Mitilini (Lesbos), Istanbul
2026 Sails: Nov 5, More...

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