Italy Cruise Departures

Cruises that depart from Mediterranean: Italy

Cruises that visit Italy

See all River Cruises that depart from Italy

Click on a cruise ship itinerary sailing from Italy (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just Italy), please visit: Cruise Search or try our Virtual Cruise Advisor™.

Related areas: Ancona : Bari : Brindisi : Cagliari : Catania : Cernobbio : Civitavecchia : Fusina : Genoa : La Spezia : Lake Como : Livorno : Marghera : Messina : Milan : Naples : Napoli : Olbia : Palermo : Ravenna : Rome : Savona : Taranto : Trieste : Venice

Cunard Line, Queen Victoria

21 Night - Adriatic and Western Mediterranean
Starting in Civitavecchia (tours to Rome), Italy, Tarragona, Spain, Palma De Mallorca, Spain, Villefranche, France, Marseille, France, Barcelona, Spain, Ibiza, Spain, Cagliari, Sardinia, Italy, Messina Strait, Italy (Transit), Messina, Sicily, Italy, Salerno (tours to Capri or Pompeii), Italy, Amalfi Coast Sail By, IT, Civitavecchia (tours to Rome), Italy, Messina Strait, Italy (Transit), Cephalonia, Greece, Corfu, Greece, Kotor, Montenegro, Split, Croatia, Trieste, Italy
2026 Sails: Aug 10, More...

Explora Journeys, EXPLORA I

14 Night - An Extended Journey Into Riviera Romance & Italian Marvels
Starting in Civitavecchia (Rome), Porto Santo Stefano (Argentario), Monte Carlo, Saint-Tropez, Tarragona, Palma De Mallorca, Barcelona, Cannes, Portofino, Livorno (Florence), Porto Cervo (Sardinia), Ajaccio (Corsica), Civitavecchia (Rome)
2026 Sails: Aug 10, More...

Explora Journeys, EXPLORA I

7 Night - A Journey of Treasured Secrets & Chic Promenades
Starting in Civitavecchia (Rome), Porto Santo Stefano (Argentario), Monte Carlo, Saint-Tropez, Tarragona, Palma De Mallorca, Barcelona
2026 Sails: Aug 10, More...

Explora Journeys, EXPLORA II

7 Night - A Journey from Venetian Elegance to Stunning Nature & Tranquil Harbour Hues
Starting in Fusina (Venice), Rovinj, Dubrovnik, Croatia, Brindisi, Fiskardo (Cephalonia), Milos, Piraeus (Athens)
2026 Sails: Aug 10, More...

Explora Journeys, EXPLORA II

14 Night - An Extended Journey Through Golden Shores & Legendary Lands
Starting in Fusina (Venice), Rovinj, Dubrovnik, Croatia, Brindisi, Fiskardo (Cephalonia), Milos, Piraeus (Athens), Bari, Nydri, Lefkada, Pylos, Katapola, Mykonos, Piraeus (Athens)
2026 Sails: Aug 10, More...

Norwegian Cruise Line, Norwegian Viva

9 Night - Europe - Classic Mediterranean
Starting in Venice (Ravenna), Italy, Dubrovnik, Croatia, Kotor, Montenegro, Amalfi Coast (Salerno), Italy, Civitavecchia Rome, Italy, Livorno / Florence / Pisa, Italy, Nice / Monaco (Villefranche), France, Palma Majorca, Spain, Barcelona, Spain
2026 Sails: Aug 10, More...

Oceania Cruises, Oceania Nautica

20 Night - Adriatic & Iberia Discovery
Starting in Venice (Fusina), Pula / Rovinj, Dubrovnik, Croatia, Kotor, Igoumenitsa, Gallipoli, Messina (Sicily), Sorrento / Capri, Rome (Civitavecchia), Barcelona, Palma De Mallorca, Cartagena ES, Malaga, Casablanca, Seville (Cadiz), Portimao, Lisbon, Gijon, Spain, Bilbao
2026 Sails: Aug 10, More...

Oceania Cruises, Oceania Nautica

10 Night - Dalmatian & Italian Gems
Starting in Venice (Fusina), Pula / Rovinj, Dubrovnik, Croatia, Kotor, Igoumenitsa, Gallipoli, Messina (Sicily), Sorrento / Capri, Rome (Civitavecchia), Barcelona
2026 Sails: Aug 10, More...

Royal Caribbean, Brilliance of the Seas

7 Night - Italy, Croatia & the Adriatic
Starting in Trieste, Italy, Koper, Slovenia, Split, Croatia, Dubrovnik, Croatia, Kotor, Montenegro, Naples, Italy, Rome (Civitavecchia), Italy
2026 Sails: Aug 10, More...

MSC Cruises, MSC Opera

10 Night - Mediterranean
Starting in Genoa (Portofino), Italy, Marseille (Provence), France, Malaga (Granada), Spain, Cadiz (Seville), Spain, Lisbon (Cascais), Portugal, Alicante, Spain, Mahon Minorque, Olbia, Italy, Genoa (Portofino), Italy
2026 Sails: Aug 11, More...

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