Rome Cruise Departures

Cruises that depart from Mediterranean: Italy: Rome

Cruises that visit Rome

Click on a cruise ship itinerary sailing from Rome (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just Rome), please visit: Cruise Search or try our Virtual Cruise Advisor™.

7 Night - Journey to Antiquities
Starting in Rome (Civitavecchia), Naples, Sicily (Messina), Sail the Ionian Sea, Crete (Souda Bay), Ephesus (Kusadasi), Athens (Piraeus)
2026 Sails: Apr 4, More...

Viking Ocean, Viking Jupiter

Regent Seven Seas, Seven Seas Voyager

9 Night - Pesto, Paella & Paradise
Starting in Rome (Civitavecchia), Portoferraio (Elba Island), La Spezia (Cinque Terre), Villefranche, Cruising the Balearic Sea, Alicante, Valencia, Ibiza, Barcelona (Tarragona)
2026 Sails: Apr 17, More...

Regent Seven Seas, Seven Seas Splendor

13 Night - Venetian Vistas
Starting in Rome (Civitavecchia), Amalfi / Positano, Trapani (Sicily), La Goulette, Valletta, Cruising the Mediterranean Sea, Argostoli (Cephalonia), Brindisi, Kotor, Dubrovnik, Croatia, Split, Cruising the Adriatic Sea, Koper, Venice (Fusina)
2026 Sails: Apr 19, More...

Viking Ocean, Viking Sea

7 Night - Italian Sojourn
Starting in Rome (Civitavecchia), Naples, Sicily (Messina), Crotone, Bari, Sibenik, Venice (Fusina)
2026 Sails: Apr 19, More...

Royal Caribbean, Odyssey of the Seas

9 Night - Greek Isles Cruise
Starting in Rome (Civitavecchia), Italy, Chania (Souda), Crete, Greece, Santorini, Greece, Ephesus (Kusadasi), Turkey, Mykonos, Greece, Athens (Piraeus), Greece, Naples, Italy, Rome (Civitavecchia), Italy
2026 Sails: Apr 24, More...

Windstar, Wind Star

8 Night - Enchanting Greece & the Amalfi Coast
Starting in Rome, Ponza, Sorrento, Amalfi, Messina (Taormina), Gythion, Monemvasia, Athens, Greece
2026 Sails: Apr 24, More...

Celebrity Cruises, Celebrity Constellation

11 Night - Best of Italy & Croatia Cruise
Starting in Rome (Civitavecchia), Italy, Florence / Pisa (La Spezia), Italy, Amalfi Coast (Salerno), Italy, Sicily (Messina), Italy, Kotor, Montenegro, Brindisi, Italy, Dubrovnik, Croatia, Split, Croatia, Trieste, Italy
2026 Sails: Apr 27, More...

Viking Ocean, Viking Mars

7 Night - Iconic Western Mediterranean
Starting in Rome (Civitavecchia), Florence / Pisa (Livorno), Monte Carlo, Marseille, Sete, Barcelona
2026 Sails: Apr 27, More...

Oceania Cruises, Oceania Marina

14 Night - Rivieras, Minarets & More
Starting in Rome (Civitavecchia), Cinque Terre (La Spezia), Saint-Tropez, Barcelona, Malaga, Seville (Cadiz), Casablanca, Agadir, Arrecife (Lanzarote), Santa Cruz de Tenerife, Santa Cruz de La Palma, Funchal (Madeira), Lisbon
2026 Sails: Apr 28, More...

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