Rome Cruise Departures
Cruises that depart from Mediterranean: Italy: Rome
Cruises that visit Rome
See all River Cruises that depart from Rome
7 Night - Greek Isles Cruise
Starting in Rome (Civitavecchia), Italy, Santorini, Greece, Ephesus (Kusadasi), Turkey, Mykonos, Greece, Naples, Italy, Rome (Civitavecchia), Italy
2026 Sails: Aug 16, Aug 23, Aug 30, Sep 6, Sep 13, Oct 4, More...
11 Night - Greece, Turkey & Italy Cruise
Starting in Rome (Civitavecchia), Italy, Chania (Souda), Crete, Greece, Ephesus (Kusadasi), Turkey, Istanbul, Turkey, Santorini, Greece, Mykonos, Greece, Naples, Italy, Rome (Civitavecchia), Italy
2026 Sails: Aug 17, Oct 19, 2027: May 24, Aug 16, Sep 27, More...
7 Night - Greek Isles & Italy Cruise
Starting in Rome (Civitavecchia), Italy, Naples, Italy, Catania, Sicily, Italy, Santorini, Greece, Ephesus (Kusadasi), Turkey, Mykonos, Greece, Athens (Piraeus), Greece
2026 Sails: Aug 17, More...
7 Night - Western Mediterranean Cruise
Starting in Rome (Civitavecchia), Italy, Naples, Italy, Barcelona, Spain, Palma De Mallorca, Spain, Florence / Pisa (La Spezia), Italy, Rome (Civitavecchia), Italy
2026 Sails: Aug 20, More...
9 Night - Italian Riviera & France
Starting in Rome (Civitavecchia), Italy, Naples, Italy, Portofino, Italy, Florence / Pisa (La Spezia), Italy, Nice (Villefranche), France, Provence (Marseille), France, Barcelona, Spain
2026 Sails: Aug 25, More...
7 Night - Jewels of the Italian and French Rivieras
Starting in Rome, Bastia, Cannes, Monte Carlo, Genoa, Italy, Portofino, Porto Ercole, Rome
2026 Sails: Aug 26, More...7 Night - Western Mediterranean Cruise
Starting in Rome (Civitavecchia), Italy, Naples, Italy, Barcelona, Spain, Palma De Mallorca, Spain, Provence (Marseille), France, Florence / Pisa (La Spezia), Italy, Rome (Civitavecchia), Italy
2026 Sails: Aug 27, Sep 3, Sep 17, Oct 1, Oct 8, Oct 15, More...10 Night - Italy, Greece & Croatia Cruise
Starting in Rome (Civitavecchia), Italy, Sicily (Messina), Italy, Olympia (Katakolon), Greece, Corfu, Greece, Montenegro, Split, Croatia, Dubrovnik, Croatia, Naples, Italy, Rome (Civitavecchia), Italy
2026 Sails: Aug 28, More...
7 Night - Sorrentine Peninsula Sojourn Cruise
Starting in Rome (Civitavecchia), Bonifacio, Corsica, Ponza, Amalfi, Positano, Sorrento, Capri, Rome (Civitavecchia)
2026 Sails: Aug 29, More...
11 Night - Best of Italy & Croatia Cruise
Starting in Rome (Civitavecchia), Italy, Florence / Pisa (Livorno), Italy, Amalfi Coast (Salerno), Italy, Sicily (Messina), Italy, Kotor, Montenegro, Dubrovnik, Croatia, Split, Croatia, Zadar, Croatia, Ravenna, Italy
2026 Sails: Aug 31, More...
Cruises that depart from Mediterranean: Italy: Rome
Cruises that visit Rome
See all River Cruises that depart from Rome
Click on a cruise ship itinerary sailing from Rome (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just Rome), please visit: Cruise Search or try our Virtual Cruise Advisor™.
7 Night - Greek Isles CruiseStarting in Rome (Civitavecchia), Italy, Santorini, Greece, Ephesus (Kusadasi), Turkey, Mykonos, Greece, Naples, Italy, Rome (Civitavecchia), Italy
2026 Sails: Aug 16, Aug 23, Aug 30, Sep 6, Sep 13, Oct 4, More...
Deal link -> Special
11 Night - Greece, Turkey & Italy CruiseStarting in Rome (Civitavecchia), Italy, Chania (Souda), Crete, Greece, Ephesus (Kusadasi), Turkey, Istanbul, Turkey, Santorini, Greece, Mykonos, Greece, Naples, Italy, Rome (Civitavecchia), Italy
2026 Sails: Aug 17, Oct 19, 2027: May 24, Aug 16, Sep 27, More...
7 Night - Greek Isles & Italy CruiseStarting in Rome (Civitavecchia), Italy, Naples, Italy, Catania, Sicily, Italy, Santorini, Greece, Ephesus (Kusadasi), Turkey, Mykonos, Greece, Athens (Piraeus), Greece
2026 Sails: Aug 17, More...
7 Night - Western Mediterranean CruiseStarting in Rome (Civitavecchia), Italy, Naples, Italy, Barcelona, Spain, Palma De Mallorca, Spain, Florence / Pisa (La Spezia), Italy, Rome (Civitavecchia), Italy
2026 Sails: Aug 20, More...
9 Night - Italian Riviera & FranceStarting in Rome (Civitavecchia), Italy, Naples, Italy, Portofino, Italy, Florence / Pisa (La Spezia), Italy, Nice (Villefranche), France, Provence (Marseille), France, Barcelona, Spain
2026 Sails: Aug 25, More...
7 Night - Jewels of the Italian and French RivierasStarting in Rome, Bastia, Cannes, Monte Carlo, Genoa, Italy, Portofino, Porto Ercole, Rome
2026 Sails: Aug 26, More...
7 Night - Western Mediterranean CruiseStarting in Rome (Civitavecchia), Italy, Naples, Italy, Barcelona, Spain, Palma De Mallorca, Spain, Provence (Marseille), France, Florence / Pisa (La Spezia), Italy, Rome (Civitavecchia), Italy
2026 Sails: Aug 27, Sep 3, Sep 17, Oct 1, Oct 8, Oct 15, More...
10 Night - Italy, Greece & Croatia CruiseStarting in Rome (Civitavecchia), Italy, Sicily (Messina), Italy, Olympia (Katakolon), Greece, Corfu, Greece, Montenegro, Split, Croatia, Dubrovnik, Croatia, Naples, Italy, Rome (Civitavecchia), Italy
2026 Sails: Aug 28, More...
7 Night - Sorrentine Peninsula Sojourn CruiseStarting in Rome (Civitavecchia), Bonifacio, Corsica, Ponza, Amalfi, Positano, Sorrento, Capri, Rome (Civitavecchia)
2026 Sails: Aug 29, More...
11 Night - Best of Italy & Croatia CruiseStarting in Rome (Civitavecchia), Italy, Florence / Pisa (Livorno), Italy, Amalfi Coast (Salerno), Italy, Sicily (Messina), Italy, Kotor, Montenegro, Dubrovnik, Croatia, Split, Croatia, Zadar, Croatia, Ravenna, Italy
2026 Sails: Aug 31, More...
