Rome Cruise Departures
Cruises that depart from Mediterranean: Italy: Rome
Cruises that visit Rome
See all River Cruises that depart from Rome
10 Night - Mediterranean Isles
Starting in Rome (Civitavecchia), Naples / Pompeii, Messina (Sicily), Valletta, Trapani (Sicily), Tunis (La Goulette), Cagliari (Sardinia), Mahon (Menorca), Palma De Mallorca, Barcelona
2026 Sails: Nov 15, More...
25 Night - Europe to the Caribbean
Starting in Rome (Civitavecchia), Naples / Pompeii, Messina (Sicily), Valletta, Trapani (Sicily), Tunis (La Goulette), Cagliari (Sardinia), Mahon (Menorca), Palma De Mallorca, Barcelona, Valencia, Alicante, Malaga, Funchal (Madeira), San Juan, Puerto Plata, Dominican Republic, Miami
2026 Sails: Nov 15, More...
7 Night - Italian Sojourn
Starting in Rome (Civitavecchia), Naples, Sicily (Messina), Crotone, Bari, Sibenik, Venice (Fusina)
2026 Sails: Nov 18, More...
14 Night - Mediterranean & Adriatic Odyssey
Starting in Rome (Civitavecchia), Naples, Sicily (Syracuse IT), Sail the Mediterranean Sea, Bari, Split, Zadar, Venice (Fusina), Ancona, Dubrovnik, Croatia, Corfu (Kerkyra), Kalamata, Crete (Souda Bay), Athens (Piraeus)
2026 Sails: Nov 28, 2028: Feb 7, More...
19 Night - Mediterranean Isles Legacy
Starting in Rome (Civitavecchia), Bastia (Corsica), Florence / Pisa / Tuscany (Livorno), Cinque Terre (La Spezia), Toulon, Palamos, Palma De Mallorca, Barcelona, Alicante, Almeria, Gibraltar, Casablanca, Agadir, Arrecife (Lanzarote), Las Palmas De Gran Canaria, Santa Cruz de Tenerife, Santa Cruz de La Palma, Funchal (Madeira), Lisbon
2026 Sails: Dec 2, More...
7 Night - Mediterranean Passage
Starting in Rome (Civitavecchia), Bastia (Corsica), Florence / Pisa / Tuscany (Livorno), Cinque Terre (La Spezia), Toulon, Palamos, Palma De Mallorca, Barcelona
2026 Sails: Dec 2, More...
7 Night - Journey to Antiquities
Starting in Rome (Civitavecchia), Naples, Sicily (Messina), Sail the Ionian Sea, Crete (Souda Bay), Ephesus (Kusadasi), Athens (Piraeus)
2026 Sails: Dec 2, Dec 30, 2027: Feb 24, 2028: Feb 17, More...
7 Night - Italy & Greece Cruise : Amalfi Coast, Siracusa & Olympia
Starting in Rome (Civitavecchia), Amalfi Coast (Salerno), Siracusa, Sicily, Olympia (Katakolon), Chania (Souda), Crete, Athens (Piraeus)
2026 Sails: Dec 5, More...
7 Night - Iconic Western Mediterranean
Starting in Rome (Civitavecchia), Florence / Pisa (Livorno), Villefranche-Sur-Mer, Marseille, Sete, Barcelona
2026 Sails: Dec 5, More...
7 Night - Iconic Western Mediterranean
Starting in Rome (Civitavecchia), Florence / Pisa (Livorno), Villefranche-Sur-Mer, Marseille, Sete, Barcelona
2026 Sails: Dec 7, More...
Cruises that depart from Mediterranean: Italy: Rome
Cruises that visit Rome
See all River Cruises that depart from Rome
Click on a cruise ship itinerary sailing from Rome (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just Rome), please visit: Cruise Search or try our Virtual Cruise Advisor™.
10 Night - Mediterranean IslesStarting in Rome (Civitavecchia), Naples / Pompeii, Messina (Sicily), Valletta, Trapani (Sicily), Tunis (La Goulette), Cagliari (Sardinia), Mahon (Menorca), Palma De Mallorca, Barcelona
2026 Sails: Nov 15, More...
25 Night - Europe to the CaribbeanStarting in Rome (Civitavecchia), Naples / Pompeii, Messina (Sicily), Valletta, Trapani (Sicily), Tunis (La Goulette), Cagliari (Sardinia), Mahon (Menorca), Palma De Mallorca, Barcelona, Valencia, Alicante, Malaga, Funchal (Madeira), San Juan, Puerto Plata, Dominican Republic, Miami
2026 Sails: Nov 15, More...
7 Night - Italian SojournStarting in Rome (Civitavecchia), Naples, Sicily (Messina), Crotone, Bari, Sibenik, Venice (Fusina)
2026 Sails: Nov 18, More...
14 Night - Mediterranean & Adriatic OdysseyStarting in Rome (Civitavecchia), Naples, Sicily (Syracuse IT), Sail the Mediterranean Sea, Bari, Split, Zadar, Venice (Fusina), Ancona, Dubrovnik, Croatia, Corfu (Kerkyra), Kalamata, Crete (Souda Bay), Athens (Piraeus)
2026 Sails: Nov 28, 2028: Feb 7, More...
19 Night - Mediterranean Isles LegacyStarting in Rome (Civitavecchia), Bastia (Corsica), Florence / Pisa / Tuscany (Livorno), Cinque Terre (La Spezia), Toulon, Palamos, Palma De Mallorca, Barcelona, Alicante, Almeria, Gibraltar, Casablanca, Agadir, Arrecife (Lanzarote), Las Palmas De Gran Canaria, Santa Cruz de Tenerife, Santa Cruz de La Palma, Funchal (Madeira), Lisbon
2026 Sails: Dec 2, More...
7 Night - Mediterranean PassageStarting in Rome (Civitavecchia), Bastia (Corsica), Florence / Pisa / Tuscany (Livorno), Cinque Terre (La Spezia), Toulon, Palamos, Palma De Mallorca, Barcelona
2026 Sails: Dec 2, More...
7 Night - Journey to AntiquitiesStarting in Rome (Civitavecchia), Naples, Sicily (Messina), Sail the Ionian Sea, Crete (Souda Bay), Ephesus (Kusadasi), Athens (Piraeus)
2026 Sails: Dec 2, Dec 30, 2027: Feb 24, 2028: Feb 17, More...
Deal link -> Special
7 Night - Italy & Greece Cruise : Amalfi Coast, Siracusa & OlympiaStarting in Rome (Civitavecchia), Amalfi Coast (Salerno), Siracusa, Sicily, Olympia (Katakolon), Chania (Souda), Crete, Athens (Piraeus)
2026 Sails: Dec 5, More...
7 Night - Iconic Western MediterraneanStarting in Rome (Civitavecchia), Florence / Pisa (Livorno), Villefranche-Sur-Mer, Marseille, Sete, Barcelona
2026 Sails: Dec 5, More...
7 Night - Iconic Western MediterraneanStarting in Rome (Civitavecchia), Florence / Pisa (Livorno), Villefranche-Sur-Mer, Marseille, Sete, Barcelona
2026 Sails: Dec 7, More...