Italy Cruise Departures

Cruises that depart from Mediterranean: Italy

Cruises that visit Italy

See all River Cruises that depart from Italy

Click on a cruise ship itinerary sailing from Italy (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just Italy), please visit: Cruise Search or try our Virtual Cruise Advisor™.

Related areas: Ancona : Bari : Brindisi : Cagliari : Catania : Cernobbio : Civitavecchia : Fusina : Genoa : La Spezia : Lake Como : Lecce : Livorno : Marghera : Messina : Milan : Naples : Napoli : Olbia : Palermo : Perugia : Ravenna : Rome : Savona : Taormina : Taranto : Trieste : Venice

Cunard Line, Queen Anne

8 Night - Western Mediterranean
Starting in Civitavecchia (tours to Rome), Italy, La Spezia (tours to Florence or Pisa), Italy, Marseille, France, Malaga (tours to Granada), Spain, Gibraltar, Southampton, England, UK
2026 Sails: Sep 12, More...

Regent Seven Seas, Seven Seas Navigator

10 Night - Grecian Myths
Starting in Venice (Fusina), Rijeka, Cruising the Mediterranean Sea, Zadar, Dubrovnik, Croatia, Kotor, Sarande, Cruising the Ionian Sea, Zakynthos, Gythion, Athens (Piraeus)
2026 Sails: Sep 12, More...

Star Clippers, Royal Clipper

7 Night - Rome to Nice
Starting in Civitavecchia (Port for Rome), Italy, Portoferraio / Elba, Italy, Larinella Beach / Corsica, France, Bastia (Old Town) Corsica, France, Santamanza Beach / Corsica, France, Bonifacio / Corsica, France, Alghero / Sardinia, Italy, Calvi / Corsica, France, Monaco, Nice, France
2026 Sails: Sep 12, More...

Star Clippers, Star Clipper

18 Night - Grand Voyage : Rome to Athens
Starting in Civitavecchia (Port for Rome), Italy, Lipari / Aeolian Islands, Italy, Stromboli, Italy (Sailing in Area), Messina, Sicily, Italy, Amalfi, Italy, Sorrento, Italy, Ponza / Pontine Islands, Italy, Civitavecchia (Port for Rome), Italy, Ponza / Pontine Islands, Italy, Palmarola / Pontine Islands, Italy, Sorrento, Italy, Lipari / Aeolian Islands, Italy, Stromboli, Italy (Sailing in Area), Taormina, Sicily, Italy, Syracuse IT, Sicily, Italy, Katakolon, Greece, Gythio, Greece, Monemvasia, Greece, Hydra, Greece, Piraeus (Port of Athens), Greece
2026 Sails: Sep 12, More...

Costa Cruise Lines, Costa Fascinosa

9 Night - Western Mediterranean from Taranto
Starting in Taranto, Malta / La Valletta, La Goulette, Palermo, Napoli, Civitavecchia (Rome), Ajaccio, Savona, Marseille, Barcelona
2026 Sails: Sep 13, More...

Costa Cruise Lines, Costa Fascinosa

8 Night - Western Mediterranean from Taranto
Starting in Taranto, Malta / La Valletta, La Goulette, Palermo, Napoli, Civitavecchia (Rome), Ajaccio, Savona, Marseille
2026 Sails: Sep 13, More...

Costa Cruise Lines, Costa Fascinosa

7 Night - Western Mediterranean from Taranto
Starting in Taranto, Malta / La Valletta, La Goulette, Palermo, Napoli, Civitavecchia (Rome), Ajaccio, Savona
2026 Sails: Sep 13, More...

Costa Cruise Lines, Costa Fascinosa

5 Night - Western Mediterranean from Taranto
Starting in Taranto, Malta / La Valletta, La Goulette, Palermo, Napoli, Civitavecchia (Rome)
2026 Sails: Sep 13, More...

Costa Cruise Lines, Costa Pacifica

7 Night - Western Mediterranean from Savona
Starting in Savona, La Seyne (St Tropez), Palma De Mallorca, Alicante, Olbia, Civitavecchia (Rome), Savona
2026 Sails: Sep 13, More...

MSC Cruises, MSC Armonia

7 Night - Mediterranean
Starting in Venice / Marghera, Italy, Dubrovnik, Croatia, Corfu, Greece, Kotor, Montenegro, Brindisi (Lecce), Italy, Split, Croatia, Venice / Marghera, Italy
2026 Sails: Sep 13, 2027: Aug 8, More...

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