Italy Cruise Departures

Cruises that depart from Mediterranean: Italy

Cruises that visit Italy

See all River Cruises that depart from Italy

Click on a cruise ship itinerary sailing from Italy (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just Italy), please visit: Cruise Search or try our Virtual Cruise Advisor™.

Related areas: Ancona : Bari : Brindisi : Cagliari : Catania : Cernobbio : Civitavecchia : Fusina : Genoa : La Spezia : Lake Como : Livorno : Marghera : Messina : Milan : Naples : Napoli : Olbia : Palermo : Ravenna : Rome : Savona : Taranto : Trieste : Venice

Windstar, Wind Spirit

14 Night - Star Collector : Corsica, Sardinia & Amalfi Memories
Starting in Rome, Ponza, Amalfi, Lipari, Cruising Stromboli, Italy, Porto Cervo, Italy, Porto Vecchio, France, Rome, Bastia, Ajaccio, France, Bonifacio, France, Alghero, Italy, Golfo Aranci, Italy, Rome
2026 Sails: Jul 16, More...

Avalon Waterways Tours, Avalon Envision Tours

18 Night - Timeless Rivers of Europe : the Rhine and Seine with Swiss Alps, in Lake Como & in Lucerne
Starting in Lake Como, Italy, Lake Como, Lake Como / Lucerne, Switzerland, Lucerne / Swiss Alps / Basel (Embarkation), Breisach, Germany Excursion to Black Forest, Kehl Excursion to Strasbourg, France, Mainz, Germany Excursion to Heidelberg, Rudesheim / Rhine Gorge, Cologne, Amsterdam, Holland, Amsterdam (Disembarkation) Paris, France (Embarkation), Vernon, Caudebec, Caudebec Excursion to Normandy, Rouen, Conflans, Paris, Paris (Disembarkation)
2026 Sails: Jul 17, Oct 23, Nov 6, More...

Celebrity Cruises, Celebrity Ascent

10 Night - Italy, Greece & Croatia Cruise
Starting in Rome (Civitavecchia), Italy, Sicily (Messina), Italy, Dubrovnik, Croatia, Split, Croatia, Montenegro, Corfu, Greece, Olympia (Katakolon), Greece, Naples, Italy, Rome (Civitavecchia), Italy
2026 Sails: Jul 17, Oct 9, More...

Costa Cruise Lines, Costa Deliziosa

14 Night - Eastern Mediterranean from Marghera
Starting in Marghera, Bari, Santorini, Mykonos, Katakolon, Marghera, Bari, Corfu, Argostoli / Cephalonia, Dubrovnik, Croatia, Kotor, Montenegro, Zadar, Croatia, Marghera
2026 Sails: Jul 18, Aug 29, More...

Ritz-Carlton, Ilma

6 Night - Venice / Rome (Civitavecchia)
Starting in Venice, Zadar, Dubrovnik, Croatia, Kotor, Sorrento, Rome (Civitavecchia)
2026 Sails: Jul 18, More...

Royal Caribbean, Legend of the Seas

7 Night - Western Mediterranean
Starting in Rome (Civitavecchia), Italy, Naples, Italy, Provence (Marseille), France, Palma De Mallorca, Spain, Barcelona, Spain, Rome (Civitavecchia), Italy
2026 Sails: Jul 18, More...

SeaDream Yacht Club, SeaDream I

7 Night - Sorrentine Peninsula Sojourn Cruise
Starting in Rome (Civitavecchia), Bonifacio, Corsica, Ponza, Amalfi, Positano, Sorrento, Capri, Rome (Civitavecchia)
2026 Sails: Jul 18, Aug 29, More...

MSC Cruises, MSC Armonia

7 Night - Mediterranean
Starting in Venice / Marghera, Italy, Dubrovnik, Croatia, Corfu, Greece, Kotor, Montenegro, Brindisi (Lecce), Italy, Split, Croatia, Venice / Marghera, Italy
2026 Sails: Jul 19, Sep 6, Oct 4, More...

Princess Tours, Sun Princess Tours

27 Night - Classic Italy - Tour 4C
Starting in Venice, Italy, Florence, Italy, Rome, Italy, Civitavecchia (for Rome), Italy, Naples, Italy (for Capri and Pompeii), Crete (Chania), Greece, Kusadasi, Turkey (for Ephesus), Mykonos, Greece, Athens (Piraeus), Greece, Santorini, Greece, Montenegro, Corfu, Greece, Sicily (Messina), Italy, Barcelona, Spain, Gibraltar, Cartagena ES, La Spezia (for Florence / Pisa), Italy, Civitavecchia (for Rome), Italy
2026 Sails: Jul 19, More...

Celebrity Cruises, Celebrity Constellation

11 Night - Best of Italy & Croatia Cruise
Starting in Rome (Civitavecchia), Italy, Florence / Pisa (Livorno), Italy, Amalfi Coast (Salerno), Italy, Sicily (Messina), Italy, Dubrovnik, Croatia, Montenegro, Split, Croatia, Zadar, Croatia, Ravenna, Italy
2026 Sails: Jul 20, Sep 21, More...

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