Italy Cruise Departures

Cruises that depart from Mediterranean: Italy

Cruises that visit Italy

See all River Cruises that depart from Italy

Click on a cruise ship itinerary sailing from Italy (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just Italy), please visit: Cruise Search or try our Virtual Cruise Advisor™.

Related areas: Ancona : Bari : Brindisi : Cagliari : Catania : Cernobbio : Civitavecchia : Fusina : Genoa : La Spezia : Lake Como : Livorno : Marghera : Messina : Naples : Napoli : Olbia : Palermo : Ravenna : Rome : Savona : Taranto : Trieste : Venice

Costa Cruise Lines, Costa Smeralda

7 Night - Western Mediterranean from Savona
Starting in Savona, Marseille, Barcelona, La Goulette, Palermo, Civitavecchia, Savona
2026 Sails: Mar 14, Mar 21, Mar 28, Apr 4, More...

MSC Cruises, MSC Lirica

7 Night - Mediterranean
Starting in Bari, Italy, Piraeus (Athens), Greece, Izmir (Ephesus), Turkey, Istanbul, Turkey, Corfu, Greece, Bari, Italy
2026 Sails: Mar 14, Mar 21, More...

Princess Cruises, Sapphire Princess

7 Night - Mediterranean with Greece & Italy
Starting in Civitavecchia (for Rome), Italy, Sarande, Albania, Katakolon (for Olympia), Greece, Valletta, Malta, Sicily (Catania), Italy, Naples, Italy (for Capri and Pompeii), Civitavecchia (for Rome), Italy
2026 Sails: Mar 15, Mar 29, Apr 12, More...

Princess Cruises, Sapphire Princess

14 Night - Mediterranean with Greece, Italy & Croatia
Starting in Civitavecchia (for Rome), Italy, Sarande, Albania, Katakolon (for Olympia), Greece, Valletta, Malta, Sicily (Catania), Italy, Naples, Italy (for Capri and Pompeii), Civitavecchia (for Rome), Italy, Corfu, Greece, Dubrovnik, Croatia, Kotor, Montenegro, Naples, Italy (for Capri and Pompeii), Civitavecchia (for Rome), Italy
2026 Sails: Mar 15, Mar 29, More...

Windstar, Star Legend

8 Night - Winter Italy and the Dalmatian Coast
Starting in Rome, Naples, Messina (Taormina), Dubrovnik, Croatia, Zadar, Venice
2026 Sails: Mar 15, More...

Windstar, Star Legend

8 Night - Winter Italy and the Dalmatian Coast
Starting in Venice, Zadar, Dubrovnik, Croatia, Messina (Taormina), Naples, Rome
2026 Sails: Mar 23, More...

Windstar, Star Legend

16 Night - Star Collector : a Winter Muse in the Mediterranean
Starting in Venice, Zadar, Dubrovnik, Croatia, Messina (Taormina), Naples, Rome, Naples, Catania, Crotone, Italy, Corfu (Kerkyra), Delphi, Corinth Canal, Athens, Greece
2026 Sails: Mar 23, More...

Costa Cruise Lines, Costa Fascinosa

4 Night - Western Mediterranean from Savona
Starting in Savona, Barcelona, Marseille, Savona
2026 Sails: Mar 28, Apr 1, Apr 5, Apr 12, Apr 19, Apr 26, May 3, May 10, Oct 4, Oct 8, Oct 15, Oct 25, Nov 1, More...

MSC Cruises, MSC Lirica

6 Night - Mediterranean
Starting in Bari, Italy, Piraeus (Athens), Greece, Santorini, Greece, Katakolon (Olympia), Greece, Ancona (Urbino), Italy
2026 Sails: Mar 28, More...

MSC Cruises, MSC Lirica

7 Night - Mediterranean
Starting in Bari, Italy, Piraeus (Athens), Greece, Santorini, Greece, Katakolon (Olympia), Greece, Ancona (Urbino), Italy, Venice / Marghera, Italy
2026 Sails: Mar 28, More...

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