Italy Cruise Departures

Cruises that depart from Mediterranean: Italy

Cruises that visit Italy

See all River Cruises that depart from Italy

Click on a cruise ship itinerary sailing from Italy (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just Italy), please visit: Cruise Search or try our Virtual Cruise Advisor™.

Related areas: Ancona : Bari : Brindisi : Cagliari : Catania : Cernobbio : Civitavecchia : Fusina : Genoa : La Spezia : Lake Como : Lecce : Livorno : Marghera : Messina : Milan : Naples : Napoli : Olbia : Palermo : Perugia : Ravenna : Rome : Savona : Taranto : Trieste : Venice

Viking Ocean, Viking Star

9 Night - Empires of the Mediterranean
Starting in Venice (Fusina), Koper, Zadar, Dubrovnik, Croatia, Kotor, Corfu (Kerkyra), Katakolon (Olympia), Santorini (Thira), Athens (Piraeus)
2026 Sails: Apr 9, 2027: Sep 22, 2028: Jun 14, Aug 10, More...

Costa Cruise Lines, Costa Smeralda

6 Night - Mediterranean from Rome (Civitavecchia) to Palermo
Starting in Civitavecchia (Rome), Savona, Marseille, Barcelona, La Goulette, Palermo
2026 Sails: Apr 10, More...

Costa Cruise Lines, Costa Smeralda

7 Night - Western Mediterranean from Civitavecchia
Starting in Civitavecchia (Rome), Savona, Marseille, Barcelona, La Goulette, Palermo, Civitavecchia (Rome)
2026 Sails: Apr 10, Apr 17, Apr 24, May 1, May 8, More...

Costa Cruise Lines, Costa Toscana

5 Night - Western Mediterranean from Genova
Starting in Genoa (Portofino), Marseille, Barcelona, Cagliari, Napoli
2026 Sails: Apr 10, More...

Costa Cruise Lines, Costa Toscana

7 Night - Western Mediterranean from Genova
Starting in Genoa (Portofino), Marseille, Barcelona, Cagliari, Napoli, Civitavecchia (Rome), Genoa (Portofino)
2026 Sails: Apr 10, Apr 17, Sep 4, Sep 11, Sep 18, Sep 25, Oct 2, Oct 9, Oct 16, Oct 23, Oct 30, Nov 6, Nov 13, More...

MSC Cruises, MSC Armonia

7 Night - Mediterranean
Starting in Brindisi (Lecce), Italy, Split, Croatia, Venice / Marghera, Italy, Dubrovnik, Croatia, Corfu, Greece, Kotor, Montenegro, Brindisi (Lecce), Italy
2026 Sails: Apr 10, Apr 17, Apr 24, May 8, May 29, Jun 5, Jun 12, Jun 19, Jun 26, Jul 3, Aug 7, Aug 14, Aug 21, Aug 28, Sep 4, Sep 18, Sep 25, Oct 2, Oct 9, Oct 16, Oct 23, 2027: May 14, May 21, Jun 11, More...

MSC Cruises, MSC Lirica

7 Night - Mediterranean
Starting in Ancona (Urbino), Italy, Venice / Marghera, Italy, Kotor, Montenegro, Mykonos, Greece, Syros, Greece, Ancona (Urbino), Italy
2026 Sails: Apr 10, Apr 17, Apr 24, May 1, May 8, May 15, May 22, May 29, Jun 5, Jun 12, Jun 19, Jun 26, Jul 3, Jul 10, Jul 17, Jul 24, Jul 31, Aug 7, Aug 14, Aug 21, Aug 28, Sep 4, Sep 11, Sep 18, More...

Princess Cruises, Enchanted Princess

5 Night - Greece & Adriatic Sampler
Starting in Civitavecchia (for Rome), Italy, Kotor, Montenegro, Corfu, Greece, Civitavecchia (for Rome), Italy
2026 Sails: Apr 10, More...

Costa Cruise Lines, Costa Deliziosa

7 Night - Eastern Mediterranean from Trieste
Starting in Trieste, Bari, Kotor, Montenegro, Montenegro, Dubrovnik, Croatia, Split, Croatia, Marghera
2026 Sails: Apr 11, More...

Costa Cruise Lines, Costa Pacifica

7 Night - Western Mediterranean from Civitavecchia
Starting in Civitavecchia (Rome), Savona, Marseille, Palma De Mallorca, Alicante, La Spezia (Florence), Civitavecchia (Rome)
2026 Sails: Apr 11, More...

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