Italy Cruise Departures

Cruises that depart from Mediterranean: Italy

Cruises that visit Italy

See all River Cruises that depart from Italy

Click on a cruise ship itinerary sailing from Italy (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just Italy), please visit: Cruise Search or try our Virtual Cruise Advisor™.

Related areas: Ancona : Bari : Brindisi : Cagliari : Catania : Cernobbio : Civitavecchia : Fusina : Genoa : La Spezia : Lake Como : Livorno : Marghera : Messina : Milan : Naples : Olbia : Palermo : Perugia : Ravenna : Rome : Savona : Taormina : Taranto : Trieste : Venice

MSC Cruises, MSC Opera

10 Night - Mediterranean
Starting in Genoa (Portofino), Italy, Marseille (Provence), France, Malaga (Granada), Spain, Cadiz (Seville), Spain, Lisbon (Cascais), Portugal, Alicante, Spain, Mahon, Spain, Olbia, Italy, Genoa (Portofino), Italy
2026 Sails: Aug 21, Aug 31, Sep 10, Sep 20, Sep 30, More...

Costa Cruise Lines, Costa Deliziosa

14 Night - Eastern Mediterranean from Marghera
Starting in Marghera (Venice), Bari, Corfu, Argostoli (Cephalonia), Dubrovnik, Croatia, Kotor, Zadar, Marghera (Venice), Bari, Thira (Santorini), Mykonos, Katakolon (Olympia), Marghera (Venice)
2026 Sails: Aug 22, More...

Costa Cruise Lines, Costa Deliziosa

7 Night - Eastern Mediterranean from Marghera
Starting in Marghera (Venice), Bari, Corfu, Argostoli (Cephalonia), Dubrovnik, Croatia, Kotor, Zadar, Marghera (Venice)
2026 Sails: Aug 22, More...

Costa Cruise Lines, Costa Fascinosa

7 Night - Eastern Mediterranean from Catania
Starting in Catania, Taranto, Argostoli (Cephalonia), Mykonos, Piraeus (Athens), Malta / La Valletta, Catania
2026 Sails: Aug 22, Sep 5, More...

Costa Cruise Lines, Costa Pacifica

7 Night - Western Mediterranean from Civitavecchia
Starting in Civitavecchia (Rome), Savona, La Seyne (St Tropez), Palma De Mallorca, Valencia, Olbia (costa Smeralda), Civitavecchia (Rome)
2026 Sails: Aug 22, Aug 29, More...

Costa Cruise Lines, Costa Smeralda

7 Night - Western Mediterranean from Savona
Starting in Savona, Marseille, Barcelona, Ibiza, Palermo, Civitavecchia (Rome), Savona
2026 Sails: Aug 22, Aug 29, Sep 5, Sep 12, Sep 19, More...

MSC Cruises, MSC Lirica

7 Night - Mediterranean
Starting in Venice / Marghera, Italy, Kotor, Montenegro, Mykonos, Greece, Syros, Greece, Ancona (Urbino), Italy, Venice / Marghera, Italy
2026 Sails: Aug 22, Aug 29, Sep 5, Sep 12, Sep 19, Sep 26, Oct 3, Oct 10, Oct 17, 2027: Apr 10, Apr 17, Apr 24, May 1, May 8, May 15, May 22, May 29, Jun 5, Jun 12, Jun 19, Jun 26, Jul 3, Jul 10, Jul 17, More...

MSC Cruises, MSC Meraviglia

7 Night - Mediterranean
Starting in Naples (Pompeii), Italy, Livorno (Florence), Italy, Marseille (Provence), France, Barcelona, Spain, La Goulette, Tunisia, Palermo (Monreale), Italy, Naples (Pompeii), Italy
2026 Sails: Aug 22, Aug 29, Sep 5, Sep 12, Sep 19, Sep 26, Oct 3, Oct 10, More...

MSC Cruises, MSC Seaview

7 Night - Mediterranean
Starting in Genoa (Portofino), Italy, Civitavecchia (Rome), Italy, Palermo (Monreale), Italy, Ibiza (Balearic Islands), Spain, Barcelona, Spain, Marseille (Provence), France, Genoa (Portofino), Italy
2026 Sails: Aug 22, Aug 29, Sep 5, Sep 12, Sep 19, Sep 26, Oct 3, Oct 10, Oct 17, Oct 24, Oct 31, More...

Royal Caribbean, Explorer of the Seas

7 Night - Greece & Adriatic Cruise
Starting in Ravenna, Italy, Bay of Kotor (Cruising), Kotor, Montenegro, Athens (Piraeus), Greece, Santorini, Greece, Split, Croatia, Ravenna, Italy
2026 Sails: Aug 22, More...

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