Italy Cruise Departures

Cruises that depart from Mediterranean: Italy

Cruises that visit Italy

See all River Cruises that depart from Italy

Click on a cruise ship itinerary sailing from Italy (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just Italy), please visit: Cruise Search or try our Virtual Cruise Advisor™.

Related areas: Ancona : Bari : Brindisi : Cagliari : Catania : Cernobbio : Civitavecchia : Fusina : Genoa : La Spezia : Lake Como : Lecce : Livorno : Marghera : Messina : Milan : Naples : Napoli : Olbia : Palermo : Perugia : Ravenna : Rome : Savona : Taormina : Taranto : Trieste : Venice

Costa Cruise Lines, Costa Toscana

7 Night - Western Mediterranean from Genova
Starting in Genoa (Portofino), Marseille, Barcelona, Cagliari, Napoli, Civitavecchia (Rome), Genoa (Portofino)
2026 Sails: May 22, May 29, Jul 24, Jul 31, Aug 7, More...

MSC Cruises, MSC Armonia

7 Night - Mediterranean
Starting in Brindisi (Lecce), Italy, Split, Croatia, Venice / Marghera, Italy, Dubrovnik, Croatia, Corfu, Greece, Kotor, Montenegro, Brindisi (Lecce), Italy
2026 Sails: May 22, Jun 5, Jun 12, Jun 19, Jul 3, Jul 10, Jul 17, Jul 24, Jul 31, Aug 7, Aug 14, Aug 21, Sep 11, Sep 25, Oct 2, Oct 9, Oct 16, Oct 23, 2027: May 14, Jun 4, Jun 25, Jul 2, Jul 9, Jul 16, More...

MSC Cruises, MSC Divina

7 Night - Mediterranean
Starting in Civitavecchia (Rome), Italy, Mykonos, Greece, Kusadasi, Turkey, Marmaris, Turkey, Naples (Pompeii), Italy, Civitavecchia (Rome), Italy
2026 Sails: May 22, Jun 12, More...

MSC Cruises, MSC Lirica

7 Night - Mediterranean
Starting in Ancona (Urbino), Italy, Venice / Marghera, Italy, Kotor, Montenegro, Mykonos, Greece, Syros, Greece, Ancona (Urbino), Italy
2026 Sails: May 22, May 29, Jun 5, Jun 12, Jun 19, Jun 26, Jul 3, Jul 10, Jul 17, Jul 24, Jul 31, Aug 7, Aug 14, Aug 21, Aug 28, Sep 4, Sep 11, Sep 18, Sep 25, Oct 2, Oct 9, Oct 16, 2027: Apr 16, Apr 23, More...

MSC Cruises, MSC Meraviglia

7 Night - Mediterranean
Starting in Palermo (Monreale), Italy, Naples (Pompeii), Italy, Livorno (Florence), Italy, Marseille (Provence), France, Barcelona, Spain, La Goulette, Tunisia, Palermo (Monreale), Italy
2026 Sails: May 22, May 29, Jun 5, Jun 12, Jun 19, Jun 26, Jul 3, Jul 10, Jul 17, Jul 24, Jul 31, Aug 7, Aug 14, Aug 21, Aug 28, Sep 4, Sep 11, Sep 18, Sep 25, Oct 2, Oct 9, More...

MSC Cruises, MSC Meraviglia

4 Night - Mediterranean
Starting in Palermo (Monreale), Italy, Naples (Pompeii), Italy, Livorno (Florence), Italy, Marseille (Provence), France, Barcelona, Spain
2026 Sails: May 22, More...

Oceania Cruises, Oceania Nautica

10 Night - Italy & France Spotlight
Starting in Rome (Civitavecchia), Amalfi / Positano, Palermo (Sicily), Olbia / Porto Cervo (Sardinia), Bastia (Corsica), Piombino (Tuscany), Florence / Pisa / Tuscany (Livorno), Nice, Saint-Tropez, Toulon, Barcelona
2026 Sails: May 22, More...

Silversea, Silver Muse

9 Night - Fusina to Fusina
Starting in Fusina (Venice), Trieste, Rovinj, Kotor, Bari, Dubrovnik, Croatia, Hvar, Zadar, Fusina (Venice)
2026 Sails: May 22, More...

Costa Cruise Lines, Costa Deliziosa

7 Night - Eastern Mediterranean from Marghera
Starting in Marghera, Bari, Corfu, Zakynthos, Argostoli / Cephalonia, Dubrovnik, Croatia, Split, Marghera
2026 Sails: May 23, Jun 20, Jul 4, Aug 1, Aug 15, Sep 12, More...

Costa Cruise Lines, Costa Pacifica

7 Night - Western Mediterranean from Civitavecchia
Starting in Civitavecchia (Rome), Savona, La Seyne (St Tropez), Palma De Mallorca, Valencia, Olbia, Civitavecchia (Rome)
2026 Sails: May 23, More...

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