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Italy Cruise Departures

Cruises that depart from Mediterranean: Italy

Cruises that visit Italy

See all River Cruises that depart from Italy

Click on a cruise ship itinerary sailing from Italy (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just Italy), please visit: Cruise Search or try our Virtual Cruise Advisor™.

Related areas: Ancona : Bari : Brindisi : Cagliari : Catania : Cernobbio : Civitavecchia : Fusina : Genoa : Lake Como : Livorno : Marghera : Messina : Milan : Naples : Olbia : Palermo : Ravenna : Rome : Savona : Taranto : Trieste : Venice

Departing from
Italy
Cruise Specials

MSC Cruises, MSC World Europa
MSC World Europa Cruises7 Night - Mediterranean
Starting in Civitavecchia (Rome), Italy, Messina (Taormina), Italy, La Valletta, Malta, Barcelona, Spain, Marseille (Provence), France, Genoa (Portofino), Italy, Civitavecchia (Rome), Italy
2026 Sails: Jan 12, Jan 19, Jan 26, Feb 2, Feb 9, Feb 16, Feb 23, Mar 2, Mar 9, Mar 16, Mar 23, Mar 30, Apr 6, More...
Windstar Cruises, Star Legend
Star Legend Cruises16 Night - Star Collector : Winter in Spain and the Rivieras
Starting in Rome, Livorno, Genoa, Italy, Nice, Barcelona, Valencia, Cartagena ES, Gibraltar, Malaga, Palma De Mallorca, Barcelona
2026 Sails: Jan 12, Feb 20, More...
Windstar Cruises, Star Legend
Star Legend Cruises7 Night - Europe's Winter Riviera
Starting in Rome, Livorno, Genoa, Italy, Nice, Barcelona
2026 Sails: Jan 12, Feb 20, 2027: Nov 5, More...
Costa Cruise Lines, Costa Toscana
Costa Toscana Cruises11 Night - Western Mediterranean from Civitavecchia
Starting in Civitavecchia, Savona, Marseille, Barcelona, Alicante, Malaga, Tangier, La Goulette, Palermo, Civitavecchia
2026 Sails: Jan 13, More...
MSC Cruises, MSC Orchestra
MSC Orchestra Cruise Ship7 Night - Mediterranean
Starting in Genoa (Portofino), Italy, Livorno (Florence), Italy, Civitavecchia (Rome), Italy, Valencia, Spain, Barcelona, Spain, Marseille (Provence), France, Genoa (Portofino), Italy
2026 Sails: Jan 13, Jan 20, Jan 27, Feb 3, Feb 10, Feb 17, Feb 24, Mar 3, Mar 10, Mar 17, Mar 24, Mar 31, Apr 7, Apr 14, More...
MSC Cruises, MSC World Europa
MSC World Europa Cruises7 Night - Mediterranean
Starting in Messina (Taormina), Italy, La Valletta, Malta, Barcelona, Spain, Marseille (Provence), France, Genoa (Portofino), Italy, Civitavecchia (Rome), Italy, Messina (Taormina), Italy
2026 Sails: Jan 13, Jan 20, Jan 27, Feb 3, Feb 10, Feb 17, Feb 24, Mar 3, Mar 10, Mar 17, Mar 24, Mar 31, Apr 7, More...
Costa Cruise Lines, Costa Toscana
Costa Toscana Cruises11 Night - Western Mediterranean from Savona
Starting in Savona, Marseille, Barcelona, Alicante, Malaga, Tangier, La Goulette, Palermo, Civitavecchia, Savona
2026 Sails: Jan 14, More...
Silversea Cruises, Silver Muse
Silver Muse Cruises10 Night - Civitavecchia to Barcelona
Starting in Civitavecchia (Rome), Naples, Palermo, Sicily, Valletta, Tunis (La Goulette), Cagliari (Sardinia), Valencia, Barcelona
2026 Sails: Jan 14, More...
MSC Cruises, MSC Orchestra
MSC Orchestra Cruise Ship7 Night - Mediterranean
Starting in Civitavecchia (Rome), Italy, Valencia, Spain, Barcelona, Spain, Marseille (Provence), France, Genoa (Portofino), Italy, Livorno (Florence), Italy, Civitavecchia (Rome), Italy
2026 Sails: Jan 15, Jan 22, Jan 29, Feb 5, Feb 12, Feb 19, Feb 26, Mar 5, Mar 12, Mar 19, Mar 26, Apr 2, Apr 9, Apr 16, More...
Costa Cruise Lines, Costa Smeralda
Costa Smeralda Cruises7 Night - Western Mediterranean from Palermo
Starting in Palermo (Sicily), Civitavecchia / Rome, Italy, Savona, Italy, Marseille, France, Barcelona, Spain, Balearic sea darkest spot, La Goulette, Tunisia, Tunis Gulf, Palermo (Sicily)
2026 Sails: Jan 22, More...

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Italy Cruise Departures