Italy Cruise Departures

Cruises that depart from Mediterranean: Italy

Cruises that visit Italy

See all River Cruises that depart from Italy

Click on a cruise ship itinerary sailing from Italy (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just Italy), please visit: Cruise Search or try our Virtual Cruise Advisor™.

Related areas: Ancona : Bari : Brindisi : Cagliari : Catania : Cernobbio : Civitavecchia : Fusina : Genoa : La Spezia : Lake Como : Lecce : Livorno : Marghera : Messina : Milan : Naples : Napoli : Olbia : Palermo : Perugia : Ravenna : Rome : Savona : Taranto : Trieste : Venice

MSC Cruises, MSC Poesia

34 Night - Msc Grand Voyages
Starting in Genoa (Portofino), Italy, Marseille (Provence), France, Barcelona, Spain, Funchal (Madeira Islands), Portugal, Philipsburg, St Maarten, Ocean Cay Msc Marine Reserve, Bahamas, Miami, Cartagena CO, Colon, Panama, Panama Canal (Transit), Panama, Puntarenas, Costa Rica, Cabo San Lucas, Mexico, San Diego, Los Angeles, Seattle, Washington
2026 Sails: Apr 7, More...

MSC Cruises, MSC Splendida

7 Night - Mediterranean
Starting in Naples (Pompeii), Italy, Palermo (Monreale), Italy, La Goulette, Tunisia, Barcelona, Spain, Marseille (Provence), France, Genoa (Portofino), Italy, Naples (Pompeii), Italy
2026 Sails: Apr 7, Apr 14, More...

MSC Cruises, MSC World Europa

7 Night - Mediterranean
Starting in Messina (Taormina), Italy, La Valletta, Malta, Barcelona, Spain, Marseille (Provence), France, Genoa (Portofino), Italy, Civitavecchia (Rome), Italy, Messina (Taormina), Italy
2026 Sails: Apr 7, More...

Costa Cruise Lines, Costa Toscana

3 Night - Cruise from Naples to Marseille
Starting in Napoli, Civitavecchia (Rome), Genoa (Portofino), Marseille
2026 Sails: Apr 8, More...

MSC Cruises, MSC Orchestra

7 Night - Mediterranean
Starting in Livorno (Florence), Italy, Civitavecchia (Rome), Italy, Valencia, Spain, Barcelona, Spain, Marseille (Provence), France, Genoa (Portofino), Italy, Livorno (Florence), Italy
2026 Sails: Apr 8, Apr 15, More...

MSC Cruises, MSC Splendida

7 Night - Mediterranean
Starting in Palermo (Monreale), Italy, La Goulette, Tunisia, Barcelona, Spain, Marseille (Provence), France, Genoa (Portofino), Italy, Naples (Pompeii), Italy, Palermo (Monreale), Italy
2026 Sails: Apr 8, Apr 15, More...

Viking Ocean, Viking Jupiter

7 Night - Journey to Antiquities
Starting in Rome (Civitavecchia), Naples, Sicily (Messina), Sail the Ionian Sea, Crete (Souda Bay), Ephesus (Kusadasi), Athens (Piraeus)
2026 Sails: Apr 8, More...

Costa Cruise Lines, Costa Fascinosa

3 Night - Western Mediterranean from Savona
Starting in Savona, Barcelona, Marseille, Savona
2026 Sails: Apr 9, Apr 16, Apr 23, Apr 30, May 14, Oct 12, Oct 19, Oct 29, More...

Costa Cruise Lines, Costa Smeralda

7 Night - Western Mediterranean Roundtrip from Palermo
Starting in Palermo (Sicily), Civitavecchia / Rome, Savona, Italy, Marseille, France, Barcelona, Spain, Balearic sea darkest spot, La Goulette, Tunisia, Tunis Gulf, Palermo (Sicily)
2026 Sails: Apr 9, Apr 16, Apr 23, Apr 30, May 7, More...

Costa Cruise Lines, Costa Toscana

7 Night - Western Mediterranean from Civitavecchia
Starting in Civitavecchia (Rome), Genoa (Portofino), Marseille, Barcelona, Cagliari, Napoli, Civitavecchia (Rome)
2026 Sails: Apr 9, Apr 16, Sep 3, Sep 10, Sep 17, Sep 24, Oct 1, Oct 8, Oct 15, Oct 22, Oct 29, Nov 5, Nov 12, More...

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