Italy Cruise Departures

Cruises that depart from Mediterranean: Italy

Cruises that visit Italy

See all River Cruises that depart from Italy

Click on a cruise ship itinerary sailing from Italy (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just Italy), please visit: Cruise Search or try our Virtual Cruise Advisor™.

Related areas: Ancona : Bari : Brindisi : Cagliari : Catania : Cernobbio : Civitavecchia : Fusina : Genoa : La Spezia : Lake Como : Lecce : Livorno : Marghera : Messina : Milan : Naples : Napoli : Olbia : Palermo : Perugia : Ravenna : Rome : Savona : Taranto : Trieste : Venice

Costa Cruise Lines, Costa Smeralda

7 Night - Western Mediterranean from Savona
Starting in Savona, Marseille, Barcelona, La Goulette, Palermo, Civitavecchia (Rome), Savona
2026 Sails: Apr 11, Apr 18, Apr 25, May 2, May 9, More...

Princess Cruises, Sun Princess

14 Night - Mediterranean with Greece, Turkey, & Adriatic
Starting in Civitavecchia (for Rome), Italy, Naples, Italy (for Capri and Pompeii), Crete (Chania), Greece, Kusadasi, Turkey (for Ephesus), Mykonos, Greece, Athens (Piraeus), Greece, Santorini, Greece, Montenegro, Corfu, Greece, Sicily (Messina), Italy, Barcelona, Spain
2026 Sails: Apr 11, May 2, Jun 13, Jul 4, Jul 25, Aug 15, Sep 5, 2027: Apr 18, May 9, May 30, Aug 22, Sep 12, Oct 3, Oct 24, More...

Princess Cruises, Sun Princess

7 Night - Mediterranean with Italy & Turkey
Starting in Civitavecchia (for Rome), Italy, Naples, Italy (for Capri and Pompeii), Crete (Chania), Greece, Kusadasi, Turkey (for Ephesus), Mykonos, Greece, Athens (Piraeus), Greece
2026 Sails: Apr 11, May 2, May 23, Jun 13, Jul 4, Jul 25, Aug 15, Sep 5, Sep 26, Oct 17, 2027: Apr 18, May 9, May 30, Aug 22, Sep 12, Oct 3, Oct 24, More...

Costa Cruise Lines, Costa Deliziosa

6 Night - Cruise from Bari to Marghera
Starting in Bari, Kotor, Montenegro, Montenegro, Dubrovnik, Croatia, Split, Croatia, Marghera
2026 Sails: Apr 12, More...

Costa Cruise Lines, Costa Pacifica

7 Night - Western Mediterranean from Savona
Starting in Savona, Marseille, Palma De Mallorca, Alicante, La Spezia (Florence), Civitavecchia (Rome), Savona
2026 Sails: Apr 12, More...

MSC Cruises, MSC World Europa

5 Night - Mediterranean
Starting in Genoa (Portofino), Italy, Civitavecchia (Rome), Italy, Messina (Taormina), Italy, La Valletta, Malta, Barcelona, Spain
2026 Sails: Apr 12, More...

Princess Cruises, Sapphire Princess

7 Night - Mediterranean with Greece & Italy
Starting in Civitavecchia (for Rome), Italy, Sarande, Albania, Katakolon (for Olympia), Greece, Valletta, Malta, Sicily (Catania), Italy, Naples, Italy (for Capri and Pompeii), Civitavecchia (for Rome), Italy
2026 Sails: Apr 12, More...

Costa Cruise Lines, Costa Favolosa

10 Night - Western Mediterranean from Savona
Starting in Savona, Marseille, Malaga, Gibraltar, Cadice, Casablanca, Tangier, Barcelona, Savona
2026 Sails: Apr 13, More...

Explora Journeys, EXPLORA I

20 Night - An Extended Journey Across Waters of Light & Legend
Starting in Fusina (Venice), Zadar, Dubrovnik, Croatia, Bari, Mykonos, Volos, Skiathos, Santorini, Syros (Syra), Piraeus (Athens), Milos, Heraklion, Crete, Giardini Naxos, La Valletta, Tunis / La Goulette, Ibiza, Barcelona
2026 Sails: Apr 13, More...

Explora Journeys, EXPLORA I

11 Night - A Journey from Venetian Shores to Aegean Isles
Starting in Fusina (Venice), Zadar, Dubrovnik, Croatia, Bari, Mykonos, Volos, Skiathos, Santorini, Syros (Syra), Piraeus (Athens)
2026 Sails: Apr 13, More...

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