Italy Cruise Departures

Cruises that depart from Mediterranean: Italy

Cruises that visit Italy

See all River Cruises that depart from Italy

Click on a cruise ship itinerary sailing from Italy (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just Italy), please visit: Cruise Search or try our Virtual Cruise Advisor™.

Related areas: Ancona : Bari : Brindisi : Cagliari : Catania : Cernobbio : Civitavecchia : Fusina : Genoa : La Spezia : Lake Como : Livorno : Marghera : Messina : Milan : Naples : Olbia : Palermo : Perugia : Ravenna : Rome : Savona : Taormina : Taranto : Trieste : Venice

Royal Caribbean, Brilliance of the Seas

7 Night - Greek Isles & Italy Cruise
Starting in Rome (Civitavecchia), Italy, Naples, Italy, Sicily (Messina), Italy, Santorini, Greece, Ephesus (Kusadasi), Turkey, Mykonos, Greece, Athens (Piraeus), Greece
2026 Sails: Jul 6, Sep 28, More...

Costa Cruise Lines, Costa Toscana

4 Night - Mediterranean from Cagliari to Marseille
Starting in Cagliari, Naples, Civitavecchia (Rome), Genoa (Portofino), Marseille
2026 Sails: Jul 7, More...

MSC Cruises, MSC Musica

7 Night - Mediterranean
Starting in Genoa (Portofino), Italy, Marseille (Provence), France, Valencia, Spain, Ibiza (Balearic Islands), Spain, Cagliari (Sardinia), Italy, Civitavecchia (Rome), Italy, Genoa (Portofino), Italy
2026 Sails: Jul 7, Aug 4, More...

MSC Cruises, MSC Orchestra

7 Night - Mediterranean
Starting in Civitavecchia (Rome), Italy, Genoa (Portofino), Italy, Marseille (Provence), France, Tarragona, Spain, Valencia, Spain, Livorno (Florence), Italy, Civitavecchia (Rome), Italy
2026 Sails: Jul 7, Jul 14, Jul 21, Jul 28, Aug 4, Aug 11, Aug 18, Aug 25, Sep 1, Sep 8, Sep 15, Sep 22, Sep 29, Oct 6, Oct 13, Oct 20, More...

MSC Cruises, MSC Splendida

7 Night - Mediterranean
Starting in Livorno (Florence), Italy, Cagliari (Sardinia), Italy, Palermo (Monreale), Italy, La Valletta, Malta, Barcelona, Spain, Marseille (Provence), France, Livorno (Florence), Italy
2026 Sails: Jul 7, Jul 14, Jul 21, Jul 28, Aug 4, Aug 11, Aug 18, Aug 25, Sep 1, Sep 8, Sep 15, Sep 22, Sep 29, Oct 13, Oct 20, Oct 27, Nov 3, More...

MSC Cruises, MSC World Europa

7 Night - Mediterranean
Starting in Messina (Taormina), Italy, La Valletta, Malta, Barcelona, Spain, Marseille (Provence), France, Genoa (Portofino), Italy, Naples (Pompeii), Italy, Messina (Taormina), Italy
2026 Sails: Jul 7, Jul 14, Jul 21, Jul 28, Aug 4, Aug 11, Aug 18, Aug 25, Sep 1, Sep 8, Sep 15, Sep 22, Sep 29, Oct 6, Oct 13, Oct 20, Oct 27, More...

Oceania Cruises, Oceania Allura

21 Night - Grand Adriatic & Aegean
Starting in Trieste, Hvar, Bari, Kotor, Dubrovnik, Croatia, Corfu, Chania (Crete), Rhodes, Santorini, Athens (Piraeus), Mykonos, Ephesus (Kusadasi), Istanbul, Bozcaada (Troy), Mitilini (Lesbos), Izmir, Chios, Kos, Santorini, Athens (Piraeus)
2026 Sails: Jul 7, More...

Oceania Cruises, Oceania Allura

14 Night - Adriatic & Aegean Gems
Starting in Trieste, Hvar, Bari, Kotor, Dubrovnik, Croatia, Corfu, Chania (Crete), Rhodes, Santorini, Athens (Piraeus), Mykonos, Ephesus (Kusadasi), Istanbul
2026 Sails: Jul 7, More...

Princess Cruises, Enchanted Princess

7 Night - Mediterranean & Aegean
Starting in Civitavecchia (for Rome), Italy, Amalfi Coast (Salerno), Santorini, Greece, Kusadasi, Turkey (for Ephesus), Katakolon (for Olympia), Greece, Civitavecchia (for Rome), Italy
2026 Sails: Jul 7, Jul 21, Aug 18, Sep 1, Oct 13, Nov 10, More...

Windstar, Wind Surf

8 Night - Bella Italia - a Southern Italian Romance
Starting in Rome, Amalfi, Marina Velentia (Vibo Valentia), Italy, Reggio Calabria, Italy, Taranto, Italy, Otranto, Italy, Rab, Croatia, Venice
2026 Sails: Jul 7, More...

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