Italy Cruise Departures

Cruises that depart from Mediterranean: Italy

Cruises that visit Italy

See all River Cruises that depart from Italy

Click on a cruise ship itinerary sailing from Italy (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just Italy), please visit: Cruise Search or try our Virtual Cruise Advisor™.

Related areas: Ancona : Bari : Brindisi : Cagliari : Catania : Cernobbio : Civitavecchia : Fusina : Genoa : Lake Como : Livorno : Marghera : Messina : Milan : Naples : Olbia : Palermo : Ravenna : Rome : Savona : Taranto : Trieste : Venice

Costa Cruise Lines, Costa Smeralda

7 Night - Western Mediterranean from Civitavecchia
Starting in Civitavecchia, Savona, Marseille, Barcelona, La Goulette, Palermo, Civitavecchia
2026 Sails: Jan 30, Feb 6, Feb 13, Feb 20, Feb 27, Mar 6, More...

Costa Cruise Lines, Costa Smeralda

7 Night - Western Mediterranean from Savona
Starting in Savona, Marseille, Barcelona, La Goulette, Palermo, Civitavecchia, Savona
2026 Sails: Jan 31, Feb 7, Feb 14, Feb 21, Feb 28, Mar 7, More...

MSC Cruises, MSC Lirica

7 Night - Mediterranean
Starting in Bari, Italy, Piraeus (Athens), Greece, Izmir (Ephesus), Turkey, Istanbul, Turkey, Corfu, Greece, Bari, Italy
2026 Sails: Jan 31, More...

Silversea Cruises, Silver Muse

10 Night - Civitavecchia to Fusina
Starting in Civitavecchia (Rome), Livorno (Tuscany), Genoa, Naples, Split, Zadar, Fusina (Venice)
2026 Sails: Feb 3, More...

Windstar Cruises, Star Legend

8 Night - Winter Italy and the Dalmatian Coast
Starting in Rome, Naples, Messina (Taormina), Dubrovnik, Croatia, Zadar, Venice
2026 Sails: Feb 4, Mar 15, More...

MSC Cruises, MSC Splendida

7 Night - Mediterranean
Starting in Genoa (Portofino), Italy, Naples (Pompeii), Italy, Palermo (Monreale), Italy, La Goulette, Tunisia, Barcelona, Spain, Marseille (Provence), France, Genoa (Portofino), Italy
2026 Sails: Feb 9, Feb 16, Feb 23, Mar 2, Mar 9, Mar 16, Mar 23, Mar 30, Apr 6, Apr 13, More...

MSC Cruises, MSC World Europa

5 Night - Mediterranean
Starting in Civitavecchia (Rome), Italy, Messina (Taormina), Italy, La Valletta, Malta, Barcelona, Spain, Marseille (Provence), France
2026 Sails: Feb 9, More...

MSC Cruises, MSC Splendida

7 Night - Mediterranean
Starting in Naples (Pompeii), Italy, Palermo (Monreale), Italy, La Goulette, Tunisia, Barcelona, Spain, Marseille (Provence), France, Genoa (Portofino), Italy, Naples (Pompeii), Italy
2026 Sails: Feb 10, Feb 17, Feb 24, Mar 3, Mar 10, Mar 17, Mar 24, Mar 31, Apr 7, Apr 14, More...

Viking Ocean, Viking Vesta

7 Night - Journey to Antiquities
Starting in Rome (Civitavecchia), Naples, Sicily (Messina), Sail the Ionian Sea, Crete (Souda Bay), Ephesus (Kusadasi), Athens (Piraeus)
2026 Sails: Feb 10, Apr 4, More...

MSC Cruises, MSC Splendida

7 Night - Mediterranean
Starting in Palermo (Monreale), Italy, La Goulette, Tunisia, Barcelona, Spain, Marseille (Provence), France, Genoa (Portofino), Italy, Naples (Pompeii), Italy, Palermo (Monreale), Italy
2026 Sails: Feb 11, Feb 18, Feb 25, Mar 4, Mar 11, Mar 18, Mar 25, Apr 1, Apr 8, Apr 15, More...

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