Italy Cruise Departures

Cruises that depart from Mediterranean: Italy

Cruises that visit Italy

See all River Cruises that depart from Italy

Click on a cruise ship itinerary sailing from Italy (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just Italy), please visit: Cruise Search or try our Virtual Cruise Advisor™.

Related areas: Ancona : Bari : Brindisi : Cagliari : Catania : Cernobbio : Civitavecchia : Fusina : Genoa : La Spezia : Lake Como : Livorno : Marghera : Messina : Naples : Napoli : Olbia : Palermo : Ravenna : Rome : Savona : Taranto : Trieste : Venice

Explora Journeys, EXPLORA I

4 Night - A Journey of Living Culture & Southern European Style
Starting in Civitavecchia (Rome), Valencia, Palma De Mallorca, Barcelona
2026 Sails: Mar 29, More...

Costa Cruise Lines, Costa Pacifica

5 Night - Western Mediterranean from Savona
Starting in Savona, Marseille, Valencia, Civitavecchia, Savona
2026 Sails: Mar 30, More...

Costa Cruise Lines, Costa Pacifica

4 Night - Western Mediterranean from Savona
Starting in Savona, Marseille, Valencia, Civitavecchia
2026 Sails: Mar 30, More...

Windstar, Star Legend

8 Night - Winter in Italy and the Adriatic
Starting in Rome, Naples, Catania, Crotone, Italy, Corfu (Kerkyra), Delphi, Corinth Canal, Athens, Greece
2026 Sails: Mar 31, More...

Costa Cruise Lines, Costa Favolosa

11 Night - Western Mediterranean from Savona
Starting in Savona, Marseille, Valencia, Cartagena ES, Spain, Malaga, Cadice, Lisbon, Alicante, Barcelona, Savona
2026 Sails: Apr 2, More...

Costa Cruise Lines, Costa Pacifica

8 Night - Western Mediterranean from Civitavecchia
Starting in Civitavecchia, Savona, Marseille, Valencia, Palma De Mallorca, Ibiza, La Spezia, Civitavecchia
2026 Sails: Apr 3, More...

MSC Cruises, MSC Lirica

7 Night - Mediterranean
Starting in Ancona (Urbino), Italy, Venice / Marghera, Italy, Kotor, Montenegro, Mykonos, Greece, Syros, Greece, Ancona (Urbino), Italy
2026 Sails: Apr 3, More...

Costa Cruise Lines, Costa Pacifica

3 Night - Western Mediterranean from Savona
Starting in Savona, Marseille, Valencia, Palma De Mallorca
2026 Sails: Apr 4, More...

Costa Cruise Lines, Costa Pacifica

8 Night - Western Mediterranean from Savona
Starting in Savona, Marseille, Valencia, Palma De Mallorca, Ibiza, La Spezia, Civitavecchia, Savona
2026 Sails: Apr 4, More...

MSC Cruises, MSC Lirica

Deal link -> Special

7 Night - Mediterranean
Starting in Venice / Marghera, Italy, Kotor, Montenegro, Mykonos, Greece, Syros, Greece, Ancona (Urbino), Italy, Venice / Marghera, Italy
2026 Sails: Apr 4, Apr 11, Apr 18, Apr 25, May 2, May 9, May 16, May 23, May 30, Jun 6, Jun 13, Jun 20, Jun 27, Jul 4, Jul 11, Jul 18, Jul 25, Aug 1, Aug 8, Aug 15, Aug 22, Aug 29, Sep 5, Sep 12, More...

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