Italy Cruise Departures

Cruises that depart from Mediterranean: Italy

Cruises that visit Italy

See all River Cruises that depart from Italy

Click on a cruise ship itinerary sailing from Italy (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just Italy), please visit: Cruise Search or try our Virtual Cruise Advisor™.

Related areas: Ancona : Bari : Brindisi : Cagliari : Catania : Cernobbio : Civitavecchia : Fusina : Genoa : La Spezia : Lake Como : Livorno : Marghera : Messina : Milan : Naples : Napoli : Olbia : Palermo : Ravenna : Rome : Savona : Taranto : Trieste : Venice

Princess Cruises, Enchanted Princess

7 Night - Mediterranean & Aegean
Starting in Civitavecchia (for Rome), Italy, Katakolon (for Olympia), Greece, Santorini, Greece, Kusadasi, Turkey (for Ephesus), Amalfi Coast (Salerno), Civitavecchia (for Rome), Italy
2026 Sails: Jun 23, More...

Silversea, Silver Muse

10 Night - Civitavecchia to Fusina
Starting in Civitavecchia (Rome), Naples, Giardini Naxos (Sicily), Siracusa (Sicily), Valletta, Kotor, Dubrovnik, Croatia, Split, Zadar, Fusina (Venice)
2026 Sails: Jun 23, More...

Disney Cruise Line, Disney Dream

12 Night - Mediterranean with Greek Isles Cruise from Civitavecchia Ending in Barcelona
Starting in Civitavecchia, Messina, Corfu, Mykonos, Piraeus, Rhodes, Valletta, Barcelona
2026 Sails: Jun 24, More...

Silversea, Silver Nova

11 Night - Civitavecchia to Lavrion
Starting in Civitavecchia (Rome), Naples, Amalfi, Giardini Naxos (Sicily), Valletta, Santorini, Rhodes, Mykonos, Nafplion, Lavrion (Athens)
2026 Sails: Jun 24, More...

Star Clippers, Royal Clipper

3 Night - Croatia & Slovenia
Starting in Venice, Italy, Rovinj, Croatia, Piran, Slovenia, Venice, Italy
2026 Sails: Jun 24, More...

Norwegian Line Tours, Norwegian Pearl Tours

10 Night - Pre Venice Cruisetour
Starting in At Hotel, Venice (Ravenna), Italy, Dubrovnik, Croatia, Kotor, Montenegro, Corfu, Greece, Olympia / Katakolon, Greece, Mykonos, Greece, Santorini Island, Greece, Piraeus / Athens, Greece
2026 Sails: Jun 25, Jul 9, Jul 23, Aug 6, Aug 20, Sep 3, Sep 17, Oct 1, More...

Oceania Cruises, Oceania Nautica

7 Night - The Adriatic & Italy
Starting in Venice (Fusina), Pula / Rovinj, Dubrovnik, Croatia, Tirana (Durres), Corfu, Catania (Sicily), Sorrento / Capri, Rome (Civitavecchia)
2026 Sails: Jun 25, More...

Oceania Cruises, Oceania Nautica

17 Night - Grand Riviera Resorts
Starting in Venice (Fusina), Pula / Rovinj, Dubrovnik, Croatia, Tirana (Durres), Corfu, Catania (Sicily), Sorrento / Capri, Rome (Civitavecchia), Salerno, Taormina (Sicily), Valletta, Ibiza, Valencia, Barcelona, Provence (Marseille), Cannes, Monte Carlo
2026 Sails: Jun 25, More...

Celebrity Cruises, Celebrity Ascent

10 Night - Italy, Greece & Croatia Cruise
Starting in Rome (Civitavecchia), Italy, Corfu, Greece, Olympia (Katakolon), Greece, Montenegro, Dubrovnik, Croatia, Split, Croatia, Sicily (Messina), Italy, Naples, Italy, Rome (Civitavecchia), Italy
2026 Sails: Jun 26, More...

MSC Cruises, MSC Divina

7 Night - Mediterranean
Starting in Civitavecchia (Rome), Italy, Mykonos, Greece, Kusadasi, Turkey, Marmaris, Turkey, Naples (Pompeii), Italy, Civitavecchia (Rome), Italy
2026 Sails: Jun 26, More...

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