Italy Cruise Departures

Cruises that depart from Mediterranean: Italy

Cruises that visit Italy

See all River Cruises that depart from Italy

Click on a cruise ship itinerary sailing from Italy (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just Italy), please visit: Cruise Search or try our Virtual Cruise Advisor™.

Related areas: Ancona : Bari : Brindisi : Cagliari : Catania : Cernobbio : Civitavecchia : Fusina : Genoa : La Spezia : Lake Como : Livorno : Marghera : Messina : Milan : Naples : Olbia : Palermo : Perugia : Ravenna : Rome : Savona : Taormina : Taranto : Trieste : Venice

Princess Tours, Sun Princess Tours

13 Night - Classic Italy - Tour 4A
Starting in Venice, Italy, Florence, Italy, Rome, Italy, Civitavecchia (for Rome), Italy, Naples, Italy (for Capri and Pompeii), Crete (Chania), Greece, Kusadasi, Turkey (for Ephesus), Mykonos, Greece, Athens (Piraeus), Greece
2026 Sails: Oct 11, More...

Princess Tours, Sun Princess Tours

20 Night - Classic Italy - Tour 4B
Starting in Venice, Italy, Florence, Italy, Rome, Italy, Civitavecchia (for Rome), Italy, Naples, Italy (for Capri and Pompeii), Crete (Chania), Greece, Kusadasi, Turkey (for Ephesus), Mykonos, Greece, Athens (Piraeus), Greece, Montenegro, Corfu, Greece, Sicily (Messina), Italy, Naples, Italy (for Capri and Pompeii), Barcelona, Spain
2026 Sails: Oct 11, More...

Royal Caribbean, Odyssey of the Seas

7 Night - Greek Isles & Italy Cruise
Starting in Rome (Civitavecchia), Italy, Sicily (Messina), Italy, Santorini, Greece, Mykonos, Greece, Naples, Italy, Rome (Civitavecchia), Italy
2026 Sails: Oct 11, Oct 18, More...

Celebrity Cruises, Celebrity Constellation

11 Night - Best of Italy & Croatia Cruise
Starting in Rome (Civitavecchia), Italy, Florence / Pisa (Livorno), Italy, Amalfi Coast (Salerno), Italy, Sicily (Messina), Italy, Kotor, Montenegro, Brindisi, Italy, Split, Croatia, Zadar, Croatia, Ravenna, Italy
2026 Sails: Oct 12, More...

Costa Cruise Lines, Costa Fascinosa

3 Night - Western Mediterranean from Savona
Starting in Savona, Barcelona, Marseille, Savona
2026 Sails: Oct 12, Oct 19, Oct 29, More...

Explora Journeys, EXPLORA II

17 Night - An Extended Journey of Changing Light & Coastal Lives
Starting in Fusina (Venice), Rovinj, Dubrovnik, Croatia, Brindisi, Kotor, Milos, Piraeus (Athens), Syros (Syra), Mykonos, Santorini, Pylos, Kotor, Gallipoli, Hvar, Rijeka, Fusina (Venice)
2026 Sails: Oct 12, More...

Oceania Cruises, Oceania Sirena

7 Night - Balearic & Riviera Resorts
Starting in Rome (Civitavecchia), Florence / Pisa / Tuscany (Livorno), Porto Torres (Sardinia), Mahon (Menorca), Barcelona, Sete, Toulon, Monte Carlo
2026 Sails: Oct 12, More...

Ritz-Carlton, Evrima

5 Night - Rome (Civitavecchia) / Monte Carlo
Starting in Rome (Civitavecchia), Portoferraio, Elba, Livorno, Portofino, Saint-Tropez, Monte Carlo
2026 Sails: Oct 12, More...

Viking Ocean, Viking Star

12 Night - Mediterranean Odyssey
Starting in Venice (Chioggia), Zadar, Dubrovnik, Croatia, Corfu (Kerkyra), Sail the Ionian Sea, Naples, Rome (Civitavecchia), Florence / Pisa (Livorno), Villefranche-Sur-Mer, Marseille, Barcelona (Tarragona)
2026 Sails: Oct 12, More...

Windstar Tours, Wind Surf Tours

13 Night - Lake Como & Adriatic Romance Cruise Tour
Starting in Cernobbio, Venice, Italy, Venice, Rovinj, Split, Dubrovnik, Croatia, Kotor, Giardini Naxos, Sorrento, Rome
2026 Sails: Oct 12, More...

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