Italy Cruise Departures

Cruises that depart from Mediterranean: Italy

Cruises that visit Italy

See all River Cruises that depart from Italy

Click on a cruise ship itinerary sailing from Italy (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just Italy), please visit: Cruise Search or try our Virtual Cruise Advisor™.

Related areas: Ancona : Bari : Brindisi : Cagliari : Catania : Cernobbio : Civitavecchia : Fusina : Genoa : La Spezia : Lake Como : Livorno : Marghera : Messina : Milan : Naples : Olbia : Palermo : Perugia : Ravenna : Rome : Savona : Taormina : Taranto : Trieste : Venice

Celebrity Cruises, Celebrity Eclipse

11 Night - Adriatic & Greek Isles Cruise
Starting in Ravenna, Italy, Split, Croatia, Dubrovnik, Croatia, Kotor, Montenegro, Valletta, Malta, Rhodes, Greece, Mykonos, Greece, Santorini, Greece, Athens (Piraeus), Greece
2026 Sails: Sep 28, More...

Ritz-Carlton, Ilma

6 Night - Rome (Civitavecchia) / Venice
Starting in Rome (Civitavecchia), Sorrento, Dubrovnik, Croatia, Hvar, Zadar, Venice
2026 Sails: Sep 28, More...

Silversea, Silver Muse

9 Night - Fusina to Fusina
Starting in Fusina (Venice), Piran, Rovinj, Kotor, Bari, Dubrovnik, Croatia, Split, Zadar, Fusina (Venice)
2026 Sails: Sep 28, More...

Regent Seven Seas, Seven Seas Mariner

13 Night - Isles in Autumn
Starting in Rome (Civitavecchia), Naples / Pompeii, Cruising the Mediterranean Sea, La Goulette, Valletta, Cruising the Ionian Sea, Dubrovnik, Croatia, Bari, Kotor, Corfu, Katakolon, Santorini, Cruising the Aegean Sea, Athens (Piraeus)
2026 Sails: Sep 29, More...

Viking Ocean, Viking Vesta

Deal link -> Special

7 Night - Venice, the Adriatic & Greece
Starting in Venice (Fusina), Split, Dubrovnik, Croatia, Kotor, Corfu (Kerkyra), Katakolon (Olympia), Athens (Piraeus)
2026 Sails: Sep 29, Nov 25, More...

Viking Ocean, Viking Sky

Deal link -> Special

7 Night - Italian Sojourn
Starting in Rome (Civitavecchia), Naples, Sicily (Catania), Crotone, Bari, Sibenik, Venice (Chioggia)
2026 Sails: Sep 30, More...

Costa Cruise Lines, Costa Smeralda

4 Night - Western Mediterranean from Palermo
Starting in Palermo, Italy, Civitavecchia / Rome, Savona, Italy, Marseille, France, Barcelona, Spain
2026 Sails: Oct 1, More...

PONANT, Le Champlain

10 Night - Ancient Civilisations, from Italy to Greece
Starting in Civitavecchia (Rome), Salerno, Reggio di Calabria, Catania, Sicily, Gallipoli, Parga, Katakolon, Crossing the Corinth Canal, Itea, Nafplion, Hydra, Athens
2026 Sails: Oct 1, More...

Carnival Cruise Lines, Carnival Legend

9 Night - Croatia Greece & Italy
Starting in Civitavecchia (Rome), Italy, Split, Croatia, Kotor, Montenegro, Dubrovnik, Croatia, Corfu, Greece, Naples (Amalfi / Pompeii), Italy, Civitavecchia (Rome), Italy
2026 Sails: Oct 2, More...

Celebrity Cruises, Celebrity Constellation

10 Night - Best of Italy & Croatia Cruise
Starting in Ravenna, Italy, Split, Croatia, Dubrovnik, Croatia, Kotor, Montenegro, Sicily (Messina), Italy, Amalfi Coast (Salerno), Italy, Portofino, Italy, Florence / Pisa (La Spezia), Italy, Rome (Civitavecchia), Italy
2026 Sails: Oct 2, More...

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