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Italy Cruise Departures

Cruises that depart from Mediterranean: Italy

Cruises that visit Italy

See all River Cruises that depart from Italy

Click on a cruise ship itinerary sailing from Italy (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just Italy), please visit: Cruise Search or try our Virtual Cruise Advisor™.

Related areas: Ancona : Bari : Brindisi : Cagliari : Catania : Cernobbio : Civitavecchia : Fusina : Genoa : Lake Como : Livorno : Marghera : Messina : Milan : Naples : Olbia : Palermo : Ravenna : Rome : Savona : Taranto : Trieste : Venice

Departing from
Italy
Cruise Specials

MSC Cruises, MSC Fantasia
MSC Fantasia Cruise Ship9 Night - Mediterranean
Starting in Trieste (Venice), Italy, Katakolon (Olympia), Greece, Piraeus (Athens), Greece, Kusadasi, Turkey, Istanbul, Turkey, Corfu, Greece, Bari, Italy, Trieste (Venice), Italy
2026 Sails: May 12, Oct 30, More...
Oceania Cruises, Oceania Sirena
Oceania Sirena Cruises7 Night - Adriatic & Ionian Artistry
Starting in Rome (Civitavecchia), Salerno, Taormina (Sicily), Argostoli (Cephalonia), Tirana (Durres), Hvar, Zadar, Venice (Fusina)
2026 Sails: May 12, More...
Princess Cruises, Enchanted Princess
Enchanted Princess Cruises7 Night - Mediterranean & Aegean
Starting in Civitavecchia (for Rome), Italy, Naples, Italy (for Capri and Pompeii), Santorini, Greece, Kusadasi, Turkey (for Ephesus), Katakolon (for Olympia), Greece, Civitavecchia (for Rome), Italy
2026 Sails: May 12, More...
Viking Ocean, Viking Vesta
Viking Vesta Cruises7 Night - Italian Sojourn
Starting in Venice (Fusina), Sibenik, Bari, Crotone, Sicily (Messina), Naples, Rome (Civitavecchia)
2026 Sails: May 12, More...
Viking Ocean, Viking Vesta
Viking Vesta Cruises14 Night - Mediterranean & Italian Sojourn
Starting in Venice (Fusina), Sibenik, Bari, Crotone, Sicily (Messina), Naples, Rome (Civitavecchia), Florence / Pisa (Livorno), Villefranche-Sur-Mer, Marseille, Sete, Barcelona
2026 Sails: May 12, More...
Explora Journeys, EXPLORA I
EXPLORA I Cruises14 Night - An Extended Journey from Italian Gems to Riviera Delights
Starting in Civitavecchia (Rome), Sorrento, Palermo (Sicily), Tunis / La Goulette, Ibiza, Mahon (Menorca), Barcelona, Marseille, Porto Cervo (Sardinia), Portofino, Livorno (Florence), Villefranche-Sur-Mer (Nice), Barcelona
2026 Sails: May 13, More...
Explora Journeys, EXPLORA I
EXPLORA I Cruises7 Night - A Journey to Italian Hidden Gems & the Heartbeat of Catalan Culture
Starting in Civitavecchia (Rome), Sorrento, Palermo (Sicily), Tunis / La Goulette, Ibiza, Mahon (Menorca), Barcelona
2026 Sails: May 13, More...
MSC Cruises, MSC Opera
MSC Opera Cruise Ship10 Night - Mediterranean
Starting in Genoa (Portofino), Italy, Marseille (Provence), France, Malaga (Granada), Spain, Cadiz (Seville), Spain, Lisbon (Cascais), Portugal, Alicante, Spain, Mahon, Spain, Olbia, Italy, Genoa (Portofino), Italy
2026 Sails: May 13, May 23, Jun 2, Jun 12, Jul 2, Jul 12, Jul 22, Aug 11, Aug 21, Aug 31, Sep 10, Sep 20, Sep 30, More...
Viking Ocean, Viking Jupiter
Viking Jupiter Cruises7 Night - Iconic Western Mediterranean
Starting in Rome (Civitavecchia), Florence / Pisa (Livorno), Villefranche-Sur-Mer, Marseille, Sete, Barcelona
2026 Sails: May 13, More...
Windstar Cruise Tours, Wind Surf Cruise Tours
Wind Surf Cruise Tours10 Night - Vatican & Croatian Coastlines Cruise Tour
Starting in Venice, Rovinj, Split, Dubrovnik, Croatia, Kotor, Giardini Naxos, Sorrento, Rome
2026 Sails: May 13, Aug 18, More...

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Italy Cruise Departures