Italy Cruise Departures

Cruises that depart from Mediterranean: Italy

Cruises that visit Italy

See all River Cruises that depart from Italy

Click on a cruise ship itinerary sailing from Italy (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just Italy), please visit: Cruise Search or try our Virtual Cruise Advisor™.

Related areas: Ancona : Bari : Brindisi : Cagliari : Catania : Civitavecchia : Fusina : Genoa : La Spezia : Lake Como : Livorno : Marghera : Messina : Milan : Naples : Olbia : Palermo : Perugia : Ravenna : Rome : Savona : Taormina : Taranto : Trieste : Venice

Silversea, Silver Dawn

14 Night - Civitavecchia to Lisbon
Starting in Civitavecchia (Rome), Naples, Valletta, Trapani, Sicily, Tunis (La Goulette), Cagliari (Sardinia), Cartagena ES, Spain, Malaga (Costa del Sol), Cadiz, Lisbon
2026 Sails: Nov 25, More...

Silversea, Silver Dawn

7 Night - Civitavecchia to Cagliari
Starting in Civitavecchia (Rome), Naples, Valletta, Trapani, Sicily, Tunis (La Goulette), Cagliari (Sardinia)
2026 Sails: Nov 25, More...

Viking Ocean, Viking Vesta

7 Night - Venice, the Adriatic & Greece
Starting in Venice (Fusina), Split, Dubrovnik, Croatia, Kotor, Corfu (Kerkyra), Katakolon (Olympia), Athens (Piraeus)
2026 Sails: Nov 25, More...

Costa Cruise Lines, Costa Toscana

7 Night - Western Mediterranean from Palermo
Starting in Palermo (Sicily), Civitavecchia / Rome, Savona, Italy, Marseille, France, Barcelona, Spain, Palma De Mallorca, Spain, Palermo (Sicily)
2026 Sails: Nov 26, Dec 3, Dec 10, Dec 17, Dec 24, Dec 31, 2027: Jan 7, Jan 14, Jan 21, Jan 28, Feb 4, More...

MSC Cruises, MSC Sinfonia

7 Night - Mediterranean
Starting in Civitavecchia (Rome), Italy, Valencia, Spain, Barcelona, Spain, Marseille (Provence), France, Genoa (Portofino), Italy, Livorno (Florence), Italy, Civitavecchia (Rome), Italy
2026 Sails: Nov 26, Dec 3, Dec 10, Dec 17, Dec 24, Dec 31, 2027: Jan 7, Feb 11, Feb 18, Feb 25, Mar 4, Mar 11, Mar 18, Mar 25, More...

Costa Cruise Lines, Costa Toscana

7 Night - Western Mediterranean from Civitavecchia
Starting in Civitavecchia (Rome), Savona, Marseille, Barcelona, Palma De Mallorca, Palermo, Civitavecchia (Rome)
2026 Sails: Nov 27, Dec 4, Dec 11, Dec 18, Dec 25, 2027: Jan 1, Jan 8, Jan 15, Jan 22, Jan 29, Feb 5, Feb 12, Feb 19, Feb 26, Mar 5, Mar 12, Mar 19, Mar 26, More...

Costa Cruise Lines, Costa Toscana

7 Night - Western Mediterranean from Savona
Starting in Savona, Marseille, Barcelona, Palma De Mallorca, Palermo, Civitavecchia (Rome), Savona
2026 Sails: Nov 28, Dec 5, Dec 12, Dec 19, Dec 26, 2027: Jan 2, Jan 9, Jan 16, Jan 23, Jan 30, Feb 20, Feb 27, Mar 6, Mar 13, Mar 20, Mar 27, More...

Viking Ocean, Viking Star

14 Night - Mediterranean & Adriatic Odyssey
Starting in Rome (Civitavecchia), Naples, Sicily (Syracuse IT), Sail the Mediterranean Sea, Bari, Split, Zadar, Venice (Fusina), Ancona, Dubrovnik, Croatia, Corfu (Kerkyra), Kalamata, Crete (Souda Bay), Athens (Piraeus)
2026 Sails: Nov 28, 2028: Feb 7, More...

MSC Cruises, MSC Magnifica

6 Night - Mediterranean
Starting in Naples (Pompeii), Italy, Messina (Taormina), Italy, La Valletta, Malta, Barcelona, Spain, Marseille (Provence), France, Genoa (Portofino), Italy
2026 Sails: Nov 30, More...

Oceania Cruises, Oceania Sirena

19 Night - Mediterranean Isles Legacy
Starting in Rome (Civitavecchia), Bastia (Corsica), Florence / Pisa / Tuscany (Livorno), Cinque Terre (La Spezia), Toulon, Palamos, Palma De Mallorca, Barcelona, Alicante, Almeria, Gibraltar, Casablanca, Agadir, Arrecife (Lanzarote), Las Palmas De Gran Canaria, Santa Cruz de Tenerife, Santa Cruz de La Palma, Funchal (Madeira), Lisbon
2026 Sails: Dec 2, More...

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