Italy Cruise Departures

Cruises that depart from Mediterranean: Italy

Cruises that visit Italy

See all River Cruises that depart from Italy

Click on a cruise ship itinerary sailing from Italy (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just Italy), please visit: Cruise Search or try our Virtual Cruise Advisor™.

Related areas: Ancona : Bari : Brindisi : Cagliari : Catania : Cernobbio : Civitavecchia : Fusina : Genoa : Lake Como : Livorno : Marghera : Messina : Milan : Naples : Olbia : Palermo : Ravenna : Rome : Savona : Taranto : Trieste : Venice

Norwegian Cruise Line, Norwegian Epic

7 Night - Europe
Starting in Civitavecchia Rome, Italy, Amalfi Coast (Salerno), Italy, Catania, Italy, Livorno / Florence / Pisa, Italy, Nice / Monaco (Villefranche), France, Provence, Marseille, France, Barcelona, Spain
2026 Sails: May 10, May 24, Jun 7, Jun 21, Jul 5, Jul 19, Aug 2, Aug 16, Aug 30, Sep 13, More...

Star Clippers, Star Clipper

6 Night - Amalfi & Sicily
Starting in Civitavecchia (Port for Rome), Italy, Lipari / Aeolian Islands, Italy, Stromboli, Italy (Sailing in Area), Messina, Sicily, Italy, Amalfi, Italy, Ponza / Pontine Islands, Italy, Civitavecchia (Port for Rome), Italy
2026 Sails: May 10, More...

Windstar Cruise Tours, Wind Surf Cruise Tours

11 Night - Lake Como & Adriatic Romance Cruise Tour
Starting in Cernobbio, Venice, Italy, Venice, Rovinj, Split, Dubrovnik, Croatia, Kotor, Giardini Naxos, Sorrento, Rome
2026 Sails: May 10, Jul 21, Aug 15, More...

MSC Cruises, MSC Fantasia

9 Night - Mediterranean
Starting in Bari, Italy, Trieste (Venice), Italy, Katakolon (Olympia), Greece, Piraeus (Athens), Greece, Kusadasi, Turkey, Istanbul, Turkey, Corfu, Greece, Bari, Italy
2026 Sails: May 11, May 29, Jun 7, Jun 16, Jun 25, Jul 4, Jul 13, Aug 9, Aug 18, Aug 27, Sep 14, Oct 2, Oct 11, Oct 29, Nov 7, More...

Norwegian Cruise Line, Norwegian Gem

6 Night - Europe - Western Mediterranean - Rome
Starting in Civitavecchia Rome, Italy, Cannes, France, Livorno / Florence / Pisa, Italy, Messina, Italy, Amalfi Coast (Salerno), Italy, Civitavecchia Rome, Italy
2026 Sails: May 11, More...

Ritz-Carlton Yacht Collection, Ilma

7 Night - Rome (Civitavecchia) / Athens (Piraeus)
Starting in Rome (Civitavecchia), Sorrento, Pylos, Chania (Souda), Crete, Santorini, Milos, Athens (Piraeus)
2026 Sails: May 11, More...

Azamara, Azamara Quest

10 Night - Croatia & Italy Cruise : Zadar, Amalfi & Sorrento
Starting in Venice (Fusina), Koper, Zadar, Dubrovnik, Croatia, Kotor, Catania, (Sicily), Amalfi, Sorrento, Bastia, Corsica, Nice
2026 Sails: May 12, More...

Azamara, Azamara Quest

46 Night - Venice to Amsterdam Grand Voyage
Starting in Venice (Fusina), Koper, Zadar, Dubrovnik, Croatia, Kotor, Catania, (Sicily), Amalfi, Sorrento, Bastia, Corsica, Nice, Ajaccio, Corsica, Villefranche, Portofino (Santa Margherita), Florence / Pisa (Livorno), Provence (Marseille), Sete, Palamos, Mahon, Menorca, Barcelona, Valencia, Cartagena ES, Malaga, Gibraltar, Seville, Lisbon, Porto (Leixoes), Bilbao, Pasajes, San Sebastian, Bordeaux, Saint Peter Port, Saint-malo, Cherbourg, Rouen (Paris), Honfleur, Dunkirk, Antwerp, Amsterdam (Ijmuiden)
2026 Sails: May 12, More...

MSC Cruises, MSC Fantasia

9 Night - Mediterranean
Starting in Trieste (Venice), Italy, Katakolon (Olympia), Greece, Piraeus (Athens), Greece, Kusadasi, Turkey, Istanbul, Turkey, Corfu, Greece, Bari, Italy, Trieste (Venice), Italy
2026 Sails: May 12, May 30, More...

Oceania Cruises, Oceania Sirena

7 Night - Adriatic & Ionian Artistry
Starting in Rome (Civitavecchia), Salerno, Taormina (Sicily), Argostoli (Cephalonia), Tirana (Durres), Hvar, Zadar, Venice (Fusina)
2026 Sails: May 12, More...

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