Italy Cruise Departures

Cruises that depart from Mediterranean: Italy

Cruises that visit Italy

See all River Cruises that depart from Italy

Click on a cruise ship itinerary sailing from Italy (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just Italy), please visit: Cruise Search or try our Virtual Cruise Advisor™.

Related areas: Ancona : Bari : Brindisi : Cagliari : Catania : Cernobbio : Civitavecchia : Fusina : Genoa : La Spezia : Lake Como : Livorno : Marghera : Messina : Milan : Naples : Olbia : Palermo : Perugia : Ravenna : Rome : Savona : Taormina : Taranto : Trieste : Venice

Costa Cruise Lines, Costa Fascinosa

7 Night - Western Mediterranean from Taranto
Starting in Taranto, Malta / La Valletta, La Goulette (Tunis), Palermo, Naples, Civitavecchia (Rome), Ajaccio (Corsica), Savona
2026 Sails: Sep 13, More...

Costa Cruise Lines, Costa Fascinosa

5 Night - Western Mediterranean from Taranto
Starting in Taranto, Malta / La Valletta, La Goulette (Tunis), Palermo, Naples, Civitavecchia (Rome)
2026 Sails: Sep 13, More...

Costa Cruise Lines, Costa Pacifica

7 Night - Western Mediterranean from Savona
Starting in Savona, La Seyne (St Tropez), Palma De Mallorca, Alicante, Olbia (costa Smeralda), Civitavecchia (Rome), Savona
2026 Sails: Sep 13, More...

Oceania Cruises, Oceania Nautica

10 Night - Dazzling Mediterranean
Starting in Rome (Civitavecchia), Sorrento / Capri, Messina (Sicily), Valletta, Dubrovnik, Croatia, Kotor, Corfu, Katakolon, Santorini, Athens (Piraeus)
2026 Sails: Sep 13, More...

Cunard Line, Queen Victoria

Deal link -> Special

7 Night - France and Italy
Starting in Civitavecchia (tours to Rome), Italy, Marseille, France, Villefranche, France, Genoa, Italy, La Spezia (tours to Florence or Pisa), Italy, Civitavecchia (tours to Rome), Italy
2026 Sails: Sep 14, More...

Cunard Line, Queen Victoria

Deal link -> Special

14 Night - Istanbul, Greek Islands and Mediterranean
Starting in Civitavecchia (tours to Rome), Italy, Marseille, France, Villefranche, France, Genoa, Italy, La Spezia (tours to Florence or Pisa), Italy, Civitavecchia (tours to Rome), Italy, Messina Strait, Italy (Transit), Rhodes, Greece, Kusadasi (tours to Ephesus), Turkey, Dardanelles Strait, Turkey (Transit), Istanbul, Turkey
2026 Sails: Sep 14, More...

Oceania Cruises, Oceania Allura

12 Night - Artifacts & Antiquities
Starting in Rome (Civitavecchia), Amalfi / Positano, Salerno, Cagliari (Sardinia), Trapani (Sicily), Valletta, Agios Nikolaos (Crete), Milos, Ephesus (Kusadasi), Skiathos, Istanbul
2026 Sails: Sep 14, More...

Princess Cruises, Enchanted Princess

10 Night - Mediterranean with Greek Isles & Italy
Starting in Civitavecchia (for Rome), Italy, Naples, Italy (for Capri and Pompeii), Dubrovnik, Croatia, Split, Croatia, Kotor, Montenegro, Corfu, Greece, Katakolon (for Olympia), Greece, Crete (Heraklion), Greece, Mykonos, Greece, Athens (Piraeus), Greece
2026 Sails: Sep 15, More...

Princess Cruises, Enchanted Princess

21 Night - The Best of the Mediterranean
Starting in Civitavecchia (for Rome), Italy, Naples, Italy (for Capri and Pompeii), Dubrovnik, Croatia, Split, Croatia, Kotor, Montenegro, Corfu, Greece, Katakolon (for Olympia), Greece, Crete (Heraklion), Greece, Mykonos, Greece, Athens (Piraeus), Greece, Santorini, Greece, Kusadasi, Turkey (for Ephesus), Istanbul, Turkey, Rhodes, Greece, Sicily (Messina), Italy, Valletta, Malta, Civitavecchia (for Rome), Italy
2026 Sails: Sep 15, More...

Ritz-Carlton, Ilma

7 Night - Venice / Venice
Starting in Venice, Dubrovnik, Croatia, Kotor, Hvar, Zadar, Piran, Venice
2026 Sails: Sep 15, More...

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