Italy Cruise Departures

Cruises that depart from Mediterranean: Italy

Cruises that visit Italy

See all River Cruises that depart from Italy

Click on a cruise ship itinerary sailing from Italy (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just Italy), please visit: Cruise Search or try our Virtual Cruise Advisor™.

Related areas: Ancona : Bari : Brindisi : Cagliari : Catania : Cernobbio : Civitavecchia : Fusina : Genoa : La Spezia : Lake Como : Lecce : Livorno : Marghera : Messina : Milan : Naples : Napoli : Olbia : Palermo : Perugia : Ravenna : Rome : Savona : Taormina : Taranto : Trieste : Venice

Windstar, Wind Surf

8 Night - Classic Italy & Dalmatian Coast
Starting in Venice, Rovinj, Split, Dubrovnik, Croatia, Kotor, Giardini Naxos, Sorrento, Rome
2026 Sails: Jul 24, Aug 18, More...

Windstar, Wind Surf

16 Night - Star Collector : Southern Italian Enchantment & Balkan Beaches
Starting in Venice, Rovinj, Split, Dubrovnik, Croatia, Kotor, Giardini Naxos, Sorrento, Rome, Amalfi, Marina Velentia (Vibo Valentia), Italy, Reggio Calabria, Italy, Taranto, Italy, Otranto, Italy, Rab, Croatia, Venice
2026 Sails: Jul 24, More...

Costa Cruise Lines, Costa Deliziosa

7 Night - Eastern Mediterranean from Marghera
Starting in Marghera, Bari, Corfu, Argostoli / Cephalonia, Dubrovnik, Croatia, Kotor, Montenegro, Zadar, Marghera
2026 Sails: Jul 25, Aug 22, Sep 5, More...

Princess Cruises, Sun Princess

14 Night - Mediterranean with Greece, Turkey, & Adriatic
Starting in Civitavecchia (for Rome), Italy, Naples, Italy (for Capri and Pompeii), Crete (Chania), Greece, Kusadasi, Turkey (for Ephesus), Mykonos, Greece, Athens (Piraeus), Greece, Santorini, Greece, Montenegro, Corfu, Greece, Sicily (Messina), Italy, Barcelona, Spain
2026 Sails: Jul 25, Aug 15, Sep 5, 2027: Apr 18, May 9, May 30, Aug 22, Sep 12, Oct 3, Oct 24, More...

Royal Caribbean, Explorer of the Seas

7 Night - Greece & Croatia Cruise
Starting in Ravenna, Italy, Dubrovnik, Croatia, Athens (Piraeus), Greece, Santorini, Greece, Split, Croatia, Ravenna, Italy
2026 Sails: Jul 25, Sep 19, More...

Royal Caribbean, Legend of the Seas

8 Night - Western Mediterranean
Starting in Rome (Civitavecchia), Italy, Florence / Pisa (La Spezia), Italy, Naples, Italy, Palma De Mallorca, Spain, Malaga, Spain, Barcelona, Spain
2026 Sails: Jul 25, More...

SeaDream Yacht Club, SeaDream I

7 Night - Cruise from Rome (Civitavecchia) to Valletta
Starting in Rome (Civitavecchia), Porto Ercole, Bonifacio, Corsica, Ponza, Amalfi, Capri, Taormina (Mount Etna) Sicily, Valletta
2026 Sails: Jul 25, More...

Holland America, Oosterdam

7 Night - Western Mediterranean
Starting in Civitavecchia (Rome), Italy, Livorno (Florence / Pisa), Italy, Portofino, Italy, Marseille (Provence), France, Gibraltar, Barcelona, Spain
2026 Sails: Jul 26, 2027: Jun 19, More...

Holland America, Oosterdam

27 Night - Solar Eclipse Collectors' Voyage : Italy & Iberia
Starting in Civitavecchia (Rome), Italy, Livorno (Florence / Pisa), Italy, Portofino, Italy, Marseille (Provence), France, Gibraltar, Barcelona, Spain, Ibiza, Spain, Alicante, Spain, Malaga, Spain, Tangier, Morocco, Lisbon, Portugal, Alicante, Spain, Barcelona, Spain, Ajaccio, Corsica, France, Civitavecchia (Rome), Italy, Bari (Puglia), Italy, Kotor, Montenegro, Scenic cruising Bay of Kotor, Piraeus (Athens), Greece
2026 Sails: Jul 26, More...

Explora Journeys, EXPLORA I

14 Night - An Extended Journey of Spectacular Serenity, Mountain Views & Mythical Spirit
Starting in Civitavecchia (Rome), Port of Naples, Capri, Calvi (Corsica), Villefranche-Sur-Mer (Nice), Marseille, Mahon (Menorca), Barcelona, Ibiza, Tunis / La Goulette, La Valletta, Giardini Naxos, Sorrento, Civitavecchia (Rome)
2026 Sails: Jul 27, Aug 24, Sep 21, More...

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