Italy Cruise Departures

Cruises that depart from Mediterranean: Italy

Cruises that visit Italy

See all River Cruises that depart from Italy

Click on a cruise ship itinerary sailing from Italy (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just Italy), please visit: Cruise Search or try our Virtual Cruise Advisor™.

Related areas: Ancona : Bari : Brindisi : Cagliari : Catania : Cernobbio : Civitavecchia : Fusina : Genoa : Lake Como : Livorno : Marghera : Messina : Milan : Naples : Olbia : Palermo : Ravenna : Rome : Savona : Taranto : Trieste : Venice

MSC Cruises, MSC Opera

10 Night - Mediterranean
Starting in Genoa (Portofino), Italy, Marseille (Provence), France, Malaga (Granada), Spain, Cadiz (Seville), Spain, Lisbon (Cascais), Portugal, Alicante, Spain, Mahon, Spain, Olbia, Italy, Genoa (Portofino), Italy
2026 Sails: May 13, May 23, Jun 2, Jun 12, Jun 22, Jul 2, Jul 22, Aug 11, Aug 21, Aug 31, Sep 20, Sep 30, More...

Viking Ocean, Viking Jupiter

7 Night - Iconic Western Mediterranean
Starting in Rome (Civitavecchia), Florence / Pisa (Livorno), Villefranche-Sur-Mer, Marseille, Sete, Barcelona
2026 Sails: May 13, More...

Windstar Cruise Tours, Wind Surf Cruise Tours

10 Night - Vatican & Croatian Coastlines Cruise Tour
Starting in Venice, Rovinj, Split, Dubrovnik, Croatia, Kotor, Giardini Naxos, Sorrento, Rome
2026 Sails: May 13, Aug 18, More...

Windstar Cruises, Wind Surf

8 Night - Classic Italy & Dalmatian Coast
Starting in Venice, Rovinj, Split, Dubrovnik, Croatia, Kotor, Giardini Naxos, Sorrento, Rome
2026 Sails: May 13, Jul 24, Aug 18, More...

Windstar Cruises, Wind Surf

21 Night - Star Collector : Iconic Italy : Centerpiece of the Mediterranean
Starting in Venice, Rovinj, Split, Dubrovnik, Croatia, Kotor, Giardini Naxos, Sorrento, Rome, Syracuse, Italy, Valletta, Gozo, Porto Empedocle, Trapani, Lipari, Sorrento, Amalfi, Rome, Porto Venere, Bonifacio, France, Rome
2026 Sails: May 13, More...

Windstar Cruises, Wind Surf

18 Night - Star Collector : Culture & Charms of Italy & Croatia
Starting in Venice, Rovinj, Split, Dubrovnik, Croatia, Kotor, Giardini Naxos, Sorrento, Rome, Syracuse, Italy, Valletta, Gozo, Porto Empedocle, Trapani, Lipari, Sorrento, Amalfi, Rome
2026 Sails: May 13, More...

Costa Cruise Lines, Costa Smeralda

7 Night - Western Mediterranean Roundtrip from Palermo
Starting in Palermo (Sicily), Civitavecchia / Rome, Italy, Savona, Italy, Calanques national park bay, Marseille, France, Barcelona, Spain, Balearic sea darkest spot, Ibiza, Spain, Ibiza bay, Palermo (Sicily)
2026 Sails: May 14, May 21, Jun 4, Jun 25, Jul 9, Jul 16, Jul 23, Jul 30, Aug 6, Aug 13, Aug 20, Aug 27, More...

Emerald Cruises, Emerald Sakara

7 Night - French & Italian Rivieras with Corsica
Starting in Civitavecchia (Rome), Italy, Calvi, France, Livorno, Italy, Marina di Carrara, Italy, Porto Venere, Italy, Santa Margherita Ligure, Italy / Portofino, Italy, Monte Carlo, Monaco, Nice, France
2026 Sails: May 14, More...

Holland America Line, Oosterdam

20 Night - Dalmatian Coast, Italy & Spain Collectors' Voyage
Starting in Trieste (Venice), Italy, Split, Croatia, Dubrovnik, Croatia, Kotor, Montenegro, Scenic cruising Bay of Kotor, Kerkira, (Corfu), Greece, Taormina, Italy, Cruising Strait of Messina, Evening cruising Stromboli Volcano, Palermo, Sicily, Italy, Naples (Pompeii / Amalfi), Italy, Civitavecchia (Rome), Italy, Salerno, Italy, Palermo, Sicily, Italy, Cagliari, Sardinia, Italy, Palma De Mallorca, Spain, Alicante, Spain, Gibraltar, Cadiz (Seville), Spain, Lisbon, Portugal
2026 Sails: May 14, More...

Holland America Line, Oosterdam

10 Night - Around Italy's Boot : Dalmatian & Amalfi Coasts
Starting in Trieste (Venice), Italy, Split, Croatia, Dubrovnik, Croatia, Kotor, Montenegro, Scenic cruising Bay of Kotor, Kerkira, (Corfu), Greece, Taormina, Italy, Cruising Strait of Messina, Evening cruising Stromboli Volcano, Palermo, Sicily, Italy, Naples (Pompeii / Amalfi), Italy, Civitavecchia (Rome), Italy
2026 Sails: May 14, More...

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