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Italy Cruise Departures

Cruises that depart from Mediterranean: Italy

Cruises that visit Italy

See all River Cruises that depart from Italy

Click on a cruise ship itinerary sailing from Italy (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just Italy), please visit: Cruise Search or try our Virtual Cruise Advisor™.

Related areas: Ancona : Bari : Brindisi : Cagliari : Catania : Cernobbio : Civitavecchia : Fusina : Genoa : Lake Como : Livorno : Marghera : Messina : Milan : Naples : Olbia : Palermo : Ravenna : Rome : Savona : Taranto : Trieste : Venice

Departing from
Italy
Cruise Specials

MSC Cruises, MSC Musica
MSC Musica Cruise Ship7 Night - Mediterranean
Starting in Genoa (Portofino), Italy, Marseille (Provence), France, Valencia, Spain, Ibiza (Balearic Islands), Spain, Cagliari (Sardinia), Italy, Civitavecchia (Rome), Italy, Genoa (Portofino), Italy
2026 Sails: Apr 21, Apr 28, May 5, May 12, May 19, May 26, Jun 2, Jun 9, Jun 16, Jun 23, Jun 30, Jul 7, Jul 14, Jul 21, Jul 28, Aug 4, Aug 11, Aug 18, Aug 25, Sep 1, More...
MSC Cruises, MSC World Europa
MSC World Europa Cruises7 Night - Mediterranean
Starting in Messina (Taormina), Italy, La Valletta, Malta, Barcelona, Spain, Marseille (Provence), France, Genoa (Portofino), Italy, Naples (Pompeii), Italy, Messina (Taormina), Italy
2026 Sails: Apr 21, Apr 28, May 5, May 12, May 19, May 26, Jun 2, Jun 9, Jun 16, Jun 23, Jun 30, Jul 7, Jul 14, Jul 21, Jul 28, Aug 4, Aug 11, Aug 18, Aug 25, Sep 1, Sep 8, Sep 15, Sep 22, Sep 29, More...
MSC Cruises, MSC Splendida
MSC Splendida Cruise Ship7 Night - Mediterranean
Starting in Palermo (Monreale), Italy, La Goulette, Tunisia, Barcelona, Spain, Marseille (Provence), France, Livorno (Florence), Italy, Cagliari (Sardinia), Italy, Palermo (Monreale), Italy
2026 Sails: Apr 22, More...
Costa Cruise Lines, Costa Favolosa
Costa Favolosa Cruise Ship11 Night - Western Mediterranean from Savona
Starting in Savona, Marseille, Cartagena ES, Spain, Malaga, Gibraltar, Cadice, Lisbon, Barcelona, Savona
2026 Sails: Apr 23, More...
MSC Cruises, MSC Fantasia
MSC Fantasia Cruise Ship10 Night - Mediterranean
Starting in Genoa (Portofino), Italy, Civitavecchia (Rome), Italy, Naples (Pompeii), Italy, Barcelona, Spain, La Valletta, Malta, Corfu, Greece, Bari, Italy, Trieste (Venice), Italy
2026 Sails: Apr 23, More...
MSC Cruises, MSC Fantasia
MSC Fantasia Cruise Ship9 Night - Mediterranean
Starting in Genoa (Portofino), Italy, Civitavecchia (Rome), Italy, Naples (Pompeii), Italy, Barcelona, Spain, La Valletta, Malta, Corfu, Greece, Bari, Italy
2026 Sails: Apr 23, More...
MSC Cruises, MSC Armonia
MSC Armonia Cruise Ship7 Night - Mediterranean
Starting in Brindisi (Lecce), Italy, Split, Croatia, Venice / Marghera, Italy, Dubrovnik, Croatia, Corfu, Greece, Kotor, Montenegro, Brindisi (Lecce), Italy
2026 Sails: Apr 24, More...
MSC Divina Cruises3 Night - Mediterranean
Starting in Civitavecchia (Rome), Italy, Mykonos, Greece, Kusadasi, Turkey
2026 Sails: Apr 24, 2027: Apr 23, More...
MSC Cruises, MSC Divina
MSC Divina Cruises6 Night - Mediterranean
Starting in Civitavecchia (Rome), Italy, Mykonos, Greece, Kusadasi, Turkey, Marmaris, Turkey, Naples (Pompeii), Italy
2026 Sails: Apr 24, 2027: Apr 23, More...
MSC Cruises, MSC Divina
MSC Divina Cruises7 Night - Mediterranean
Starting in Civitavecchia (Rome), Italy, Mykonos, Greece, Kusadasi, Turkey, Marmaris, Turkey, Naples (Pompeii), Italy, Civitavecchia (Rome), Italy
2026 Sails: Apr 24, 2027: Jun 18, Jul 30, More...

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Italy Cruise Departures