Italy Cruise Departures

Cruises that depart from Mediterranean: Italy

Cruises that visit Italy

See all River Cruises that depart from Italy

Click on a cruise ship itinerary sailing from Italy (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just Italy), please visit: Cruise Search or try our Virtual Cruise Advisor™.

Related areas: Ancona : Bari : Brindisi : Cagliari : Catania : Cernobbio : Civitavecchia : Fusina : Genoa : La Spezia : Lake Como : Lecce : Livorno : Marghera : Messina : Milan : Naples : Napoli : Olbia : Palermo : Perugia : Ravenna : Rome : Savona : Taormina : Taranto : Trieste : Venice

Norwegian Cruise Line, Norwegian Gem

7 Night - Europe - Adriatic & Greece - Venice
Starting in Venice (Ravenna), Italy, Split, Croatia, Kotor, Montenegro, Dubrovnik, Croatia, Corfu, Greece, Messina, Italy, Amalfi Coast (Salerno), Italy, Civitavecchia Rome, Italy
2026 Sails: Jun 21, More...

PONANT, Le Dumont-d'Urville

10 Night - 5Th Opera Festival at Sea
Starting in Venice, Ravenna, Ancona, Otranto, Taormina, Sicily, Amalfi, Porto Santo Stefano, Livorno, Portofino, Nice
2026 Sails: Jun 22, More...

Avalon Waterways Tours, Avalon Vista Tours

11 Night - Romantic Rhine with Swiss Alps, in Lake Como & in Lucerne (Northbound)
Starting in Lake Como, Italy, Lake Como, Lake Como / Lucerne, Switzerland, Lucerne / Swiss Alps / Basel (Embarkation), Breisach, Germany Excursion to Black Forest, Kehl Excursion to Strasbourg, France, Mainz, Germany Excursion to Heidelberg, Rudesheim / Rhine Gorge, Cologne, Amsterdam, Holland, Amsterdam (Disembarkation)
2026 Sails: Jun 23, Jul 7, Jul 21, Aug 4, Aug 18, Sep 15, Oct 13, Oct 27, More...

Princess Cruises, Enchanted Princess

14 Night - Mediterranean, Aegean & Adriatic
Starting in Civitavecchia (for Rome), Italy, Katakolon (for Olympia), Greece, Santorini, Greece, Kusadasi, Turkey (for Ephesus), Amalfi Coast (Salerno), Civitavecchia (for Rome), Italy, Corfu, Greece, Dubrovnik, Croatia, Kotor, Montenegro, Naples, Italy (for Capri and Pompeii), Civitavecchia (for Rome), Italy
2026 Sails: Jun 23, More...

Princess Cruises, Enchanted Princess

7 Night - Mediterranean & Aegean
Starting in Civitavecchia (for Rome), Italy, Katakolon (for Olympia), Greece, Santorini, Greece, Kusadasi, Turkey (for Ephesus), Amalfi Coast (Salerno), Civitavecchia (for Rome), Italy
2026 Sails: Jun 23, More...

Silversea, Silver Muse

10 Night - Civitavecchia to Fusina
Starting in Civitavecchia (Rome), Naples, Giardini Naxos (Sicily), Siracusa (Sicily), Valletta, Kotor, Dubrovnik, Croatia, Split, Zadar, Fusina (Venice)
2026 Sails: Jun 23, More...

Disney Cruise Line, Disney Dream

12 Night - Mediterranean with Greek Isles Cruise from Civitavecchia Ending in Barcelona
Starting in Civitavecchia, Messina, Corfu, Mykonos, Piraeus, Rhodes, Valletta, Barcelona
2026 Sails: Jun 24, More...

Silversea, Silver Nova

11 Night - Civitavecchia to Lavrion
Starting in Civitavecchia (Rome), Naples, Amalfi, Giardini Naxos (Sicily), Valletta, Santorini, Rhodes, Mykonos, Nafplion, Lavrion (Athens)
2026 Sails: Jun 24, More...

Star Clippers, Royal Clipper

3 Night - Croatia & Slovenia
Starting in Venice, Italy, Rovinj, Croatia, Piran, Slovenia, Venice, Italy
2026 Sails: Jun 24, More...

Oceania Cruises, Oceania Nautica

7 Night - The Adriatic & Italy
Starting in Venice (Fusina), Pula / Rovinj, Dubrovnik, Croatia, Tirana (Durres), Corfu, Catania (Sicily), Sorrento / Capri, Rome (Civitavecchia)
2026 Sails: Jun 25, More...

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