Italy Cruise Departures

Cruises that depart from Mediterranean: Italy

Cruises that visit Italy

See all River Cruises that depart from Italy

Click on a cruise ship itinerary sailing from Italy (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just Italy), please visit: Cruise Search or try our Virtual Cruise Advisor™.

Related areas: Ancona : Bari : Brindisi : Cagliari : Catania : Cernobbio : Civitavecchia : Fusina : Genoa : La Spezia : Lake Como : Livorno : Marghera : Messina : Milan : Naples : Napoli : Olbia : Palermo : Ravenna : Rome : Savona : Taranto : Trieste : Venice

MSC Cruises, MSC Meraviglia

7 Night - Mediterranean
Starting in Palermo (Monreale), Italy, Naples (Pompeii), Italy, Livorno (Florence), Italy, Marseille (Provence), France, Barcelona, Spain, La Goulette, Tunisia, Palermo (Monreale), Italy
2026 Sails: May 8, May 15, May 22, May 29, Jun 5, Jun 12, Jun 19, Jun 26, Jul 3, Jul 10, Jul 17, Jul 24, Jul 31, Aug 7, Aug 14, Aug 21, Aug 28, Sep 4, Sep 11, Sep 18, Sep 25, Oct 2, Oct 9, More...

Norwegian Cruise Line, Norwegian Viva

10 Night - Greek Isles & Italy
Starting in Venice (Ravenna), Italy, Zadar, Croatia, Kotor, Montenegro, Piraeus / Athens, Greece, Santorini Island, Greece, Rhodes, Greece, Kusadasi, Turkey, Thessaloniki, Greece, Istanbul, Turkey
2026 Sails: May 8, More...

Regent Seven Seas, Seven Seas Splendor

7 Night - Ancient Sands
Starting in Rome (Civitavecchia), Naples / Pompeii, Valletta, Cruising the Mediterranean Sea, Katakolon, Santorini, Mykonos, Athens (Piraeus)
2026 Sails: May 8, More...

Silversea, Silver Spirit

7 Night - Civitavecchia to Lisbon
Starting in Civitavecchia (Rome), Livorno (Tuscany), Valencia, Cartagena ES, Spain, Portimao, Lisbon
2026 Sails: May 8, More...

Costa Cruise Lines, Costa Deliziosa

7 Night - Eastern Mediterranean from Marghera
Starting in Marghera, Bari, Kotor, Montenegro, Corfu, Dubrovnik, Croatia, Split, Croatia, Marghera
2026 Sails: May 9, More...

MSC Cruises, MSC Meraviglia

7 Night - Mediterranean
Starting in Naples (Pompeii), Italy, Livorno (Florence), Italy, Marseille (Provence), France, Barcelona, Spain, La Goulette, Tunisia, Palermo (Monreale), Italy, Naples (Pompeii), Italy
2026 Sails: May 9, May 16, May 23, May 30, Jun 6, Jun 13, Jun 20, Jun 27, Jul 4, Jul 11, Jul 18, Jul 25, Aug 1, Aug 8, Aug 15, Aug 22, Aug 29, Sep 5, Sep 12, Sep 19, Sep 26, Oct 3, Oct 10, More...

Viking Ocean, Viking Saturn

7 Night - Iconic Western Mediterranean
Starting in Rome (Civitavecchia), Florence / Pisa (Livorno), Monte Carlo, Marseille, Sete, Barcelona
2026 Sails: May 9, More...

MSC Cruises, MSC Meraviglia

7 Night - Mediterranean
Starting in Livorno (Florence), Italy, Marseille (Provence), France, Barcelona, Spain, La Goulette, Tunisia, Palermo (Monreale), Italy, Naples (Pompeii), Italy, Livorno (Florence), Italy
2026 Sails: May 10, May 17, May 24, May 31, Jun 7, Jun 14, Jun 21, Jun 28, Jul 5, Jul 12, Jul 19, Jul 26, Aug 2, Aug 9, Aug 16, Aug 23, Aug 30, Sep 6, Sep 13, Sep 20, Sep 27, Oct 4, Oct 11, More...

Norwegian Cruise Line, Norwegian Epic

7 Night - Europe
Starting in Civitavecchia Rome, Italy, Amalfi Coast (Salerno), Italy, Catania, Italy, Livorno / Florence / Pisa, Italy, Nice / Monaco (Villefranche), France, Provence, Marseille, France, Barcelona, Spain
2026 Sails: May 10, May 24, Jun 7, Jun 21, Jul 5, Jul 19, Aug 2, Aug 16, Aug 30, Sep 13, More...

Star Clippers, Star Clipper

6 Night - Amalfi & Sicily
Starting in Civitavecchia (Port for Rome), Italy, Lipari / Aeolian Islands, Italy, Stromboli, Italy (Sailing in Area), Messina, Sicily, Italy, Amalfi, Italy, Ponza / Pontine Islands, Italy, Civitavecchia (Port for Rome), Italy
2026 Sails: May 10, More...

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