Italy Cruise Departures

Cruises that depart from Mediterranean: Italy

Cruises that visit Italy

See all River Cruises that depart from Italy

Click on a cruise ship itinerary sailing from Italy (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just Italy), please visit: Cruise Search or try our Virtual Cruise Advisor™.

Related areas: Ancona : Bari : Brindisi : Cagliari : Catania : Cernobbio : Civitavecchia : Fusina : Genoa : La Spezia : Lake Como : Livorno : Marghera : Messina : Milan : Naples : Napoli : Olbia : Palermo : Ravenna : Rome : Savona : Taranto : Trieste : Venice

MSC Cruises, MSC Fantasia

9 Night - Mediterranean
Starting in Bari, Italy, Trieste (Venice), Italy, Katakolon (Olympia), Greece, Piraeus (Athens), Greece, Kusadasi, Turkey, Istanbul, Turkey, Corfu, Greece, Bari, Italy
2026 Sails: May 11, Jul 31, More...

Norwegian Cruise Line, Norwegian Gem

6 Night - Europe - Western Mediterranean - Rome
Starting in Civitavecchia Rome, Italy, Cannes, France, Livorno / Florence / Pisa, Italy, Messina, Italy, Amalfi Coast (Salerno), Italy, Civitavecchia Rome, Italy
2026 Sails: May 11, More...

Ritz-Carlton, Ilma

7 Night - Rome (Civitavecchia) / Athens (Piraeus)
Starting in Rome (Civitavecchia), Sorrento, Pylos, Chania (Souda), Crete, Santorini, Milos, Athens (Piraeus)
2026 Sails: May 11, More...

Avalon Waterways Tours, Avalon Vista Tours

11 Night - Romantic Rhine with Swiss Alps, in Lake Como & in Lucerne (Northbound)
Starting in Lake Como, Italy, Lake Como, Lake Como / Lucerne, Switzerland, Lucerne / Swiss Alps / Basel (Embarkation), Breisach, Germany Excursion to Black Forest, Kehl Excursion to Strasbourg, France, Mainz, Germany Excursion to Heidelberg, Rudesheim / Rhine Gorge, Cologne, Amsterdam, Holland, Amsterdam (Disembarkation)
2026 Sails: May 12, Jun 9, Jun 23, Jul 7, Jul 21, Aug 4, Aug 18, Sep 15, Sep 29, Oct 13, Oct 27, More...

MSC Cruises, MSC Fantasia

9 Night - Mediterranean
Starting in Trieste (Venice), Italy, Katakolon (Olympia), Greece, Piraeus (Athens), Greece, Kusadasi, Turkey, Istanbul, Turkey, Corfu, Greece, Bari, Italy, Trieste (Venice), Italy
2026 Sails: May 12, More...

Princess Cruises, Enchanted Princess

Deal link -> Special

7 Night - Mediterranean & Aegean
Starting in Civitavecchia (for Rome), Italy, Naples, Italy (for Capri and Pompeii), Santorini, Greece, Kusadasi, Turkey (for Ephesus), Katakolon (for Olympia), Greece, Civitavecchia (for Rome), Italy
2026 Sails: May 12, More...

Viking Ocean, Viking Vesta

7 Night - Italian Sojourn
Starting in Venice (Fusina), Sibenik, Bari, Crotone, Sicily (Messina), Naples, Rome (Civitavecchia)
2026 Sails: May 12, More...

Explora Journeys, EXPLORA I

14 Night - An Extended Journey from Italian Gems to Riviera Delights
Starting in Civitavecchia (Rome), Sorrento, Palermo (Sicily), Tunis / La Goulette, Ibiza, Mahon (Menorca), Barcelona, Marseille, Porto Cervo (Sardinia), Portofino, Livorno (Florence), Villefranche-Sur-Mer (Nice), Barcelona
2026 Sails: May 13, More...

Explora Journeys, EXPLORA I

7 Night - A Journey to Italian Hidden Gems & the Heartbeat of Catalan Culture
Starting in Civitavecchia (Rome), Sorrento, Palermo (Sicily), Tunis / La Goulette, Ibiza, Mahon (Menorca), Barcelona
2026 Sails: May 13, More...

MSC Cruises, MSC Grandiosa

7 Night - Mediterranean
Starting in Civitavecchia (Rome), Italy, Palma De Mallorca (Balearic Islands), Spain, Barcelona, Spain, Cannes (Cote D Azur), France, Genoa (Portofino), Italy, La Spezia (Cinque Terre), Italy, Civitavecchia (Rome), Italy
2026 Sails: May 13, May 20, May 27, Jun 3, Jun 10, Jun 17, Jun 24, Jul 1, Jul 8, Jul 15, Jul 22, Jul 29, Aug 5, Aug 12, Aug 19, Aug 26, Sep 2, Sep 9, Sep 16, Sep 23, Sep 30, Oct 7, Oct 14, Oct 21, More...

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