Italy Cruise Departures

Cruises that depart from Mediterranean: Italy

Cruises that visit Italy

See all River Cruises that depart from Italy

Click on a cruise ship itinerary sailing from Italy (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just Italy), please visit: Cruise Search or try our Virtual Cruise Advisor™.

Related areas: Ancona : Bari : Brindisi : Cagliari : Catania : Cernobbio : Civitavecchia : Fusina : Genoa : La Spezia : Lake Como : Livorno : Marghera : Messina : Milan : Naples : Olbia : Palermo : Perugia : Ravenna : Rome : Savona : Taormina : Taranto : Trieste : Venice

Princess Cruises, Enchanted Princess

7 Night - Mediterranean & Adriatic
Starting in Civitavecchia (for Rome), Italy, Corfu, Greece, Dubrovnik, Croatia, Kotor, Montenegro, Naples, Italy (for Capri and Pompeii), Civitavecchia (for Rome), Italy
2026 Sails: Jul 28, Aug 25, Sep 8, Oct 6, More...

Costa Cruise Lines, Costa Toscana

7 Night - Europe Roundtrip from Naples
Starting in Naples, Italy, Bahia De Capri, Civitavecchia / Rome, Genoa / Portofino, Bahia Del Parque Nacional De Las Calanques, Marseille, France, Barcelona, Spain, El punto mas oscuro del mar de las, Balearic Islands, Cagliari, Italy, Naples, Italy
2026 Sails: Jul 29, More...

Star Clippers, Star Clipper

11 Night - Greece, Montenegro, Croatia
Starting in Venice, Italy, Mali Losinj, Croatia, Sibenik, Croatia, Dubrovnik, Croatia, Kotor, Montenegro, Corfu, Greece, Gythio, Greece, Milos / Adamas, Greece, Mykonos, Greece, Piraeus (Port of Athens), Greece
2026 Sails: Jul 29, More...

Atlas Ocean Voyages, World Traveller

10 Night - Rome to Barcelona
Starting in Civitavecchia (Rome), Livorno (Florence / Pisa), Portofino, Nice, Saint-Tropez, Sanary-Sur-Mer (Bandol), Port-Vendres, Mahon (Menorca), Ibiza, Barcelona
2026 Sails: Jul 30, More...

Costa Cruise Lines, Costa Toscana

6 Night - Cruise from Rome (Civitavecchia) to Naples
Starting in Civitavecchia (Rome), Genoa (Portofino), Marseille, Barcelona, Cagliari, Naples
2026 Sails: Jul 30, More...

Windstar, Wind Spirit

7 Night - Italy and the Allure of the Aeolian Islands
Starting in Rome, Ponza, Amalfi, Lipari, Cruising Stromboli, Italy, Porto Cervo, Italy, Porto Vecchio, France, Rome
2026 Sails: Jul 30, More...

Avalon Waterways Tours, Avalon Envision Tours

11 Night - Romantic Rhine with Swiss Alps, in Lake Como & in Lucerne (Northbound)
Starting in Lake Como, Italy, Lake Como, Lake Como / Lucerne, Switzerland, Lucerne / Swiss Alps / Basel (Embarkation), Breisach, Germany Excursion to Black Forest, Kehl Excursion to Strasbourg, France, Mainz, Germany Excursion to Heidelberg, Rudesheim / Rhine Gorge, Cologne, Amsterdam, Holland, Amsterdam (Disembarkation)
2026 Sails: Jul 31, Aug 28, Sep 11, Oct 9, Oct 23, Nov 6, Nov 20, Dec 4, More...

Ritz-Carlton, Ilma

7 Night - Rome (Civitavecchia) / Monte Carlo
Starting in Rome (Civitavecchia), Portoferraio, Elba, Livorno, Calvi, Corsica, Saint-Tropez, Cannes, Monte Carlo
2026 Sails: Jul 31, More...

Silversea, Silver Muse

10 Night - Civitavecchia to Barcelona
Starting in Civitavecchia (Rome), Giardini Naxos (Sicily), Valletta, Trapani, Sicily, Tunis (La Goulette), Cagliari (Sardinia), Palma De Mallorca, Palamos, Barcelona
2026 Sails: Jul 31, More...

Costa Cruise Lines, Costa Deliziosa

14 Night - Eastern Mediterranean from Marghera
Starting in Marghera (Venice), Bari, Corfu, Zakynthos, Argostoli (Cephalonia), Dubrovnik, Croatia, Split, Marghera (Venice), Bari, Thira (Santorini), Mykonos, Katakolon (Olympia), Marghera (Venice)
2026 Sails: Aug 1, More...

<= Back

More =>